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Inward Ca²⁺ currents conducted by voltage-gated Ca²⁺ (Ca_v) channels couple action potentials and other depolarizing stimuli to many Ca²⁺-dependent intracellular processes, including neurotransmission, hormone secretion, and muscle contraction (Zamponi et al., 2015). In presynaptic nerve terminals, Ca_v2.1, Ca_v2.2, and Ca_v2.3 channels conduct P/Q-type, N-type, and R-type Ca²⁺ currents that trigger rapid neurotransmission (for review, see Olivera et al., 1994; Zamponi et al., 2015; Nanou and Catterall, 2018). However, only P/Q-type Ca²⁺ currents conducted by Ca_v2.1 channels can mediate short-term synaptic facilitation at the calyx of Held in mice (Inchauspe et al., 2004), pointing to a unique role of these Ca²⁺ channels in short-term synaptic plasticity.

In transfected nonneuronal cells, Ca²⁺ entry mediated by Ca_v2.1 channels causes calcium-dependent facilitation (CDF) and inactivation (CDI) during single depolarizations and in trains of repetitive depolarizing pulses (Lee et al., 1999, 2000; DeMaria et al., 2001; Catterall and Few, 2008; Christel and Lee, 2012; Ben-Johny and Yue, 2014). Both CDF and CDI of Ca_v2.1 channels are dependent on calmodulin (CaM; Lee et al., 1999, 2000; DeMaria et al., 2001). CaM preassociates with the C-terminal domain of the pore-forming α1 subunit of Ca_v2.1 channels (Erickson et al., 2001). Following Ca²⁺ binding, CaM initially interacts with the nearby IQ-like motif (IM) and causes CDF, whereas further binding of Ca²⁺/CaM to the more distal CaM-binding domain (CBD) induces CDI of Ca_v2.1 channels (DeMaria et al., 2001; Lee et al., 2003). Introducing the IM-AA mutation into the IQ-like motif of Ca_v2.

Recent developments like DALLE-2 and LaMDA are impressive and seem ready for impact. Is AI ready to change the world?

Whether you love, fear, or have mixed feelings about the future of artificial intelligence, the cultural fixation on the subject over the past decade has made it feel like the technology’s meteoric impact is just around the corner. The problem is that it is always just around the corner, yet never seems to arrive. Many hype-filled years have passed us by since the releases of Ex Machina (2014) and Westworld (2016), but it feels like we are still waiting on AI’s big splash. However, a handful of recent developments—specifically, OpenAI’s unveiling of GPT-3 and DALLE-2, and Google’s LaMDA controversy—have unleashed a new wave of excitement—and terror—around the possibility that AI’s game-changing moment is finally here.

There are several reasons why it feels it has taken a long time for AI projects to bear fruit. One is that pop culture seems almost exclusively focused on the possible endgames of the technology, rather than its broader journey. This isn’t much of a surprise. When we stream the latest sci-fi movie or binge Black Mirror episodes, we want to see killer robots and computer chip brain implants. No one is buying a ticket to see a movie about the slow, incremental rollout of existing technology—not unless it mutates and starts killing within the first 30 minutes. But while AI’s more futuristic forms are naturally the most entertaining, and provide an endless source of material for screenwriters, anyone who based their expectations for AI off of Bladerunner has got to be feeling disappointed by now.

“If cells are dreaming, [these images] are what the cells are dreaming about,” neuroscientist Carlos Ponce told The Atlantic. “It exposes the visual vocabulary of the brain, in a way that’s unbiased by our anthropomorphic perspective.”

Some neurons responded to images that vaguely resembled objects that the scientists recognized, suggesting that the researchers identified the specific neurons that corresponded with particular real-world objects. A blur that resembled a monkey’s face accompanied by a red blotch may have corresponded to another monkey in the lab that wore a red collar. Another blur that resembled a human wearing a surgical mask may have represented the woman who took care of and fed the lab’s monkeys, who wore a similar mask.

Other images that the monkey neurons responded to the most were less realistic, instead taking the form of various streaks and splotches of color, according to The Atlantic.

Just yesterday (2022−08−24) Prof. Smolin had a deep brain stimulator inserted into his left Globus Pallidus to help him better manage his symptoms of Parkinson’s Disease. Here he talks about that day, his theory of PD and the journey he had been on to getting DBS.

Nvidia’s Q2 2022 earnings revealed a dramatic dip in gaming revenue, but also some ideas on how to bring it back — including discounting its oversupply of GPUs.

An artificial intelligence system trained on words and sentences alone will never approximate human understanding.

Circa 2020 This shape changing metal discovery can lead us closer to foglet machines.

Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ, USA. E-mail: [email protected]

Received 25th August 2020, Accepted 16th November 2020.

Continue reading “Polymorphism in metal halide perovskites” »

Eavesdropping on the earliest conversations between tissues in an emerging life could tell us a lot about organ growth, fertility, and disease in general. It could help prevent early miscarriages, or even tell us how to grow whole replacement organs from scratch.

In a monumental leap in stem cell research, an experiment led by researchers from the University of Cambridge in the UK has developed a living model of a mouse embryo complete with fluttering heart tissues and the beginnings of a brain.

The research advances the recent success of a team comprised of some of the same scientists who pushed the limits on mimicking the embryonic development of mice using stem cells that had never seen the inside of a mouse womb.