Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 3426

Last week, US-Israeli startup SIRTLab announced the appointment of leading geroscience researcher Nir Barzilai as its Chief Medical Adviser. The company is focused on the development of therapeutics that boost levels of a key protein called sirtuin 6 (SIRT6), which is heavily implicated in longevity.

Sirtuins are a group of proteins found in all living organisms, including humans, that play a vital role in regulating various cellular processes. There are seven different types of sirtuins, numbered from SIRT1 to SIRT7, each with its own unique functions. In recent years, SIRT6 has gained particular attention for its potential role in promoting healthy aging, and SIRTLab has put the protein at the center of its work.

Longevity. Technology: The SIRT6 protein has been shown to regulate several critical cellular pathways, including glucose metabolism, DNA repair and inflammation – all of which play key roles in aging and longevity. One of the world’s leading authorities on SIRT6 is SIRTLab co-founder and Bar-Ilan University professor Haim Cohen, whose research is behind the company’s work to develop therapeutics with longevity-boosting potential. To learn more about SIRTLab’s longevity-first approach, we spoke to its co-founder and CEO Boaz Misholi.

Read more | >

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

Published online May 16 in the journal Cell, the report describes the behind a DNA repair pathway that counters the mistaken inclusion of a certain type of molecular building block, ribonucleotides, into genetic codes. Such mistakes are frequent in code-copying process in bacteria and other organisms. Given that ribonucleotide misincorporation can result in detrimental DNA code changes (mutations) and DNA breaks, all organisms have evolved to have a DNA repair pathway called ribonucleotide excision repair (RER) that quickly fixes such errors.

Last year a team led by Evgeny Nudler, Ph.D., the Julie Wilson Anderson Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Langone Health, published two analyses of DNA repair in living E. coli cells. They found that most of the repair of certain types of DNA damage (bulky lesions), such as those caused by UV irradiation, can occur because damaged code sections have first been identified by a called RNA . RNA polymerase motors down the DNA chain, reading the code of DNA “letters” as it transcribes instructions into RNA molecules, which then direct protein building.

Read more | >

Dont like google, but also dont want to see Micros. corner market in AI and become some monopoly, which is what AI Licenses is all about.

(Bloomberg) — Alphabet Inc. is back in the game. The artificial intelligence game, that is. Most Read from BloombergA 32-Year-Old Nears Billionaire Status by Using AI to Broker Japan MergersDebt Deadlock Spurs Late-Day Slide in US Stocks: Markets WrapGoogle Billionaire Sergey Brin Gifts $600 Million in Surging SharesBiden, McCarthy Voice Cautious Optimism on Debt Deal After TalksGoldman Banker Wins Promotion, Then Leaves for Rival Two Weeks LaterShares in the Google-owner had lagged behind other megacaps this year amid fears it was losing ground in the race to deploy AI products. Yet since it unveiled its latest AI tools at a developer’s conference last week, the stock has advanced 12%, adding $160 billion in market value and erasing its underperformance against peers like Apple Inc. and Microsoft Corp.

Read more | >

OpenAI CEO Sam Altman: “My worst fears, are that we cause significant — we the field, the technology, the industry — cause significant harm to the world…If this technology goes wrong, it can go quite wrong and we want to be vocal about that.” Full video here: https://www.c-span.org/video/?528117-1/openai-ceo-testif…telligence.

Download the FREE C-SPAN Now App. https://www.c-span.org/c-spanNow/

Discover the C-SPAN Video Library at https://www.c-span.org/quickguide/

Explore C-SPAN’s Free Educational Resources at https://www.c-span.org/classroom/

Continue reading “OpenAI CEO Sam Altman: “If this technology goes wrong, it can go quite wrong.”” | >

Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke.

A team of researchers in the McKelvey School of Engineering at Washington University in St. Louis has found a non-invasive and non-pharmaceutical method to influence glymphatic transport using , opening the opportunity to use the method to further study diseases and . Results of the work are published in the Proceedings of the National Academy of Sciences on May 15.

Hong Chen, associate professor of biomedical engineering in McKelvey Engineering and of in the School of Medicine, and her team, including Dezhuang (Summer) Ye, a postdoctoral research associate, and Si (Stacie) Chen, a former postdoctoral research associate, found the first direct evidence that focused , combined with circulating microbubbles—a technique they call FUSMB—could mechanically enhance glymphatic transport in the mouse brain.

Read more | >