ALBUQUERQUE, N.M. — In people with epilepsy, seizure-alert dogs can smell small changes in body chemistry and warn of an impending seizure an hour or more before it occurs. Inspired by this feat of nature, a team of researchers has sniffed out a way to replicate the ability with technology.
Immune checkpoint inhibitors (ICIs) have improved the landscape of cancer research over the past decade. These therapies, which target a patient’s own immune system aiming to make it stronger and more equipped to fight cancer, have provided novel and beneficial therapeutic options for patients with advanced and metastatic disease.
While ICIs can induce long-term responses and cures in patients with limited therapeutic options, they present significant challenges. First, different patients exhibit different levels of responsiveness to ICIs. So, when one patient achieves a cure, another with a similar type of cancer may remain non-responsive. While we don’t fully understand the reasons behind the disparate responsiveness of ICIs, this remains an active area of research globally. Second, ICI use can elicit toxicities known as immune-related adverse events (irAEs). In some patients irAEs can be managed and thus tolerable, especially given the anti-cancer effects. However, some patients experience severe irAEs that can significantly hinder the quality of life of cancer survivors. In some cases, serious and life-threatening irAEs can even require treatment discontinuation.
A pre-clinical study recently published in the Journal of Clinical and Experimental Cancer Research explores a potential regimen that may help confront both of these challenges. The researchers hypothesized that ICIs, if targeted directly to the lymph node (LN), could both enhance the anti-tumor response and reduce the associated irAEs.
Tell summer to go to … Well, at least keep from overheating indoors—or outdoors—with the right tips and gear.
For all of the good things you can do with OpenAI’s new chatbot, you also need to be aware of the ways it could be used by people with malicious intent.
Protecting your QSR against SaaS threats requires a comprehensive approach. Learn how an SSPM can help manage data separation, detect misconfiguration.
Researchers have accidentally found that blocking caspase enzymes can make mouse immune responses more robust.
Disregarding an ever-increasing number of modalities and approaches and indifferent to the intense competition from savvy startups and techno giants, Lego could enter the race to build a quantum computer.
Well, at least one Lego fan designer is readying the Denmark-based toy company for the quantum era.
In a product suggestion, a Lego user pitched creating IBM Quantum Computer System in Lego Ideas, a site that allows users to submit suggestions for future logo sets.
“Of course, we need to finetune everything before we can apply it to humans. But I would say that 10 years is a realistic timeline,” Ngo-Anh said.
This fine-tuning is already underway. First studies have shown that it’s possible to induce torpor in otherwise non-hibernating animals, such as rats, and bring them safely back to life a few days later. The process of triggering hibernation is rather intricate and involves reduced exposure to daylight and a period of intense feeding followed by a strict fast.
Facebook users have until August to claim their share of a $725 million class-action settlement of a lawsuit alleging privacy violations by the social media company, a new website reveals.
The lawsuit was prompted in 2018 after Facebook disclosed that the information of 87 million users was improperly shared with Cambridge Analytica.
People who had an active U.S. Facebook account between May 2007 and December 2022 have until Aug. 25 to enter a claim. Individual settlement payments haven’t yet been established because payouts depend on how many users submit claims and how long each user maintained a Facebook account.
