In the annals of scientific inquiry, few endeavors have been as audacious as the attempt to bridge the chasm between the tangible and the intangible, the empirical and the experiential. The declassification of the 1983 U.S. Army Intelligence report, “Analysis and Assessment of The Gateway Process,” offers a compelling case study in this regard. Authored by Lieutenant Colonel Wayne M. McDonnell, the report delves into altered states of consciousness, suggesting that human consciousness may transcend the physical plane, potentially supporting concepts akin to reincarnation. This proposition invites us to explore the intersection of infodynamics — the study of information dynamics within physical systems — and phenomena traditionally deemed spiritual, under the premise that all such phenomena are rooted in the natural order.
At the heart of this exploration lies the principle that information, much like energy, is conserved within the universe. This concept is reminiscent of the first law of thermodynamics, which asserts that energy cannot be created or destroyed, only transformed. In the realm of information theory, this translates to the idea that information persists, undergoing transformations but never facing annihilation. This perspective aligns with the notion that consciousness, as a form of information, may continue beyond the cessation of its current physical embodiment.
Quantum mechanics further enriches this discourse. The phenomenon of quantum entanglement, wherein particles become interconnected in such a way that the state of one instantaneously influences the state of another, regardless of the spatial separation, challenges our classical understanding of locality and separability. This non-locality suggests a deeply interconnected fabric of reality, where information is not confined to a singular point in space or time. Such a framework provides a plausible basis for understanding how consciousness, as an informational construct, could transcend individual physical forms, offering a naturalistic foundation for phenomena like reincarnation.
A new bill introduced into the US Senate claims to make us safer. Instead, it would destroy all virology research, and for no real cause.
Ever set off too many of the bitter taste receptors on your tongue? You probably spat out whatever it was in your mouth, and that’s our best guess for why we even have them: to stop us from ingesting things that might be harmful.
Our skin cells have the same receptors, which serve a similar purpose on a cellular level: to detect bitter substances. New research led by Okayama University of Science biologists builds on our knowledge of the type-2 taste receptors (TAS2Rs) found in the skin’s keratinocytes, finding their role is also to keep potentially harmful materials from sticking around and causing damage.
Once thought to be confined to the tongue, TAS2Rs are actually spread much further throughout the body. They line your colon, your stomach, and your upper airways.
Maple syrup urine disease (MSUD) is a rare genetic inborn error of metabolism characterized by recurrent life-threatening neurologic crises and progressive brain injury. The disease is typically caused by biallelic mutations in genes (branched-chain α-ketoacid dehydrogenase E1α (BCKDHA), E1β (BCKDHB), or dihydrolipoamide branched-chain transacylase (DBT)) subunits which interact to form the mitochondrial BCKDH complex that decarboxylates ketoacid derivatives of leucine, isoleucine, and valine. MSUD can be treated by a strictly controlled diet or allogeneic liver transplantation.
Now, new work demonstrates that a gene therapy prevented newborn death, normalized growth, restored coordinated expression of the affected genes, and stabilized biomarkers in a calf as well as in mice.
This work is published in Science Translational Medicine in the paper, “BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease.”