We spoke with head and neck surgeon Eduardo Diaz Jr., M.D., to learn more about laryngeal cancer.
How common is laryngeal cancer?
It’s much less common than it used to be because fewer Americans are smoking, which is a risk factor for this type of cancer. That said, laryngeal cancers represent about one-fifth of head and neck cancers.
This quickly turned out to be a record-setter. It was dubbed the Brightest Of All Time, or the “Boat,” as convenient shorthand among astronomers studying and observing the event. Not only did the Boat start out bright, it refused to fade away like other bursts.
We still do not fully know why the burst was so exceptionally bright, but our new study, published in Science Advances, provides an answer for its stubborn persistence.
The burst originated from a distance of 2.4 billion light years—relatively nearby for a GRB. But even when accounting for relative distance, the energy of the event and the radiation produced by its aftermath were off the charts. It is decidedly not normal for a cosmically distant event to deposit about a gigawatt of power into the Earth’s upper atmosphere.
“There are many exciting use cases for generative speech models, but because of the potential risks of misuse, we are not making the Voicebox model or code publicly available at this time,” the company said in a research post. “While we believe it is important to be open with the AI community and to share our research to advance the state of the art in AI, it’s also necessary to strike the right balance between openness with responsibility.”
Representatives for Meta did not immediately respond to Insider’s request for comment, made outside normal working hours.
Meta said in the news release that the model could allow visually impaired people to hear messages from friends in their voices or allow users to speak in foreign languages in their own voice. The company also said the tech opened up the possibility for creators to edit audio tracks for video or create more natural-sounding voices for virtual assistants.
By modifying the blueprint of life, researchers are endowing proteins with chemistries they’ve never had before.
Matching the sight and sound of speech—a face to a voice—in early infancy is an important foundation for later language development.
This ability, known as intersensory processing, is an essential pathway to learning new words. According to a recent study published in the journal Infancy, the degree of success at intersensory processing at only 6 months old can predict vocabulary and language outcomes at 18 months, 2 years and 3 years old.
“Adults are highly skilled at this, but infants must learn to relate what they see with what they hear. It’s a tremendous job and they do it very early in their development,” said lead author Elizabeth V. Edgar, who conducted the study as an FIU psychology doctoral student and is now a postdoctoral fellow at the Yale Child Study Center. “Our findings show that intersensory processing has its own independent contribution to language, over and above other established predictors, including parent language input and socioeconomic status.”
Freely accessible large language models have accelerated the pace of innovation, computer scientists say.
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Scientists have used stem cells to create structures that resemble human embryos in the lab, in a first that has prompted calls for stricter regulation in the rapidly advancing field.
Several different labs around the world have released pre-print studies in the past seven days describing their research, which experts said should be treated with caution as the research has not yet been peer-reviewed.
The labs used different techniques to encourage human embryonic stem cells, which can become any type of cell, to self-assemble into a structure that resembles an embryo—without needing sperm, an egg or fertilization.
ALBUQUERQUE, N.M. — In people with epilepsy, seizure-alert dogs can smell small changes in body chemistry and warn of an impending seizure an hour or more before it occurs. Inspired by this feat of nature, a team of researchers has sniffed out a way to replicate the ability with technology.
Immune checkpoint inhibitors (ICIs) have improved the landscape of cancer research over the past decade. These therapies, which target a patient’s own immune system aiming to make it stronger and more equipped to fight cancer, have provided novel and beneficial therapeutic options for patients with advanced and metastatic disease.
While ICIs can induce long-term responses and cures in patients with limited therapeutic options, they present significant challenges. First, different patients exhibit different levels of responsiveness to ICIs. So, when one patient achieves a cure, another with a similar type of cancer may remain non-responsive. While we don’t fully understand the reasons behind the disparate responsiveness of ICIs, this remains an active area of research globally. Second, ICI use can elicit toxicities known as immune-related adverse events (irAEs). In some patients irAEs can be managed and thus tolerable, especially given the anti-cancer effects. However, some patients experience severe irAEs that can significantly hinder the quality of life of cancer survivors. In some cases, serious and life-threatening irAEs can even require treatment discontinuation.
A pre-clinical study recently published in the Journal of Clinical and Experimental Cancer Research explores a potential regimen that may help confront both of these challenges. The researchers hypothesized that ICIs, if targeted directly to the lymph node (LN), could both enhance the anti-tumor response and reduce the associated irAEs.
