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This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.

Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.

Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].

Cellular senescence is a state of stable cell cycle arrest that can be triggered due to a wide range of extrinsic as well as intrinsic factors. It promotes tissue remodeling, wound repair, and cancer prevention by stopping the proliferation of damaged and aged cells. Senescent cells are characterized by metabolic and morphological alterations, reorganization of the chromatin, and release of pro-inflammatory substances known as the senescence-associated secretory phenotype (SASP) [3]. Irreparable DNA damage, loss of epigenetic information, and telomere shortening are a few factors that can initiate cellular senescence. Accumulation of senescent cells with age results in inflammation as well as the generation of reactive oxygen species (ROS).

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Continue reading “Did DunedinPACE Improve For Test #5 in 2023? Also, Is NAD Significantly Correlated With DunedinPACE?” | >

When a group of researchers asked an AI to design a robot that could walk, it created a “small, squishy and misshapen” thing that walks by spasming when filled with air.

The researchers — affiliated with Northwestern University, MIT, and the University of Vermont — published their findings in an article for the Proceedings of the National Academy of Sciences on October 3.

“We told the AI that we wanted a robot that could walk across land. Then we simply pressed a button and presto!” Sam Kriegman, an assistant professor at Northwestern University and the lead researcher behind the study, wrote in a separate blog post.

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We are arguably at “the knee” of the curve. More breakthroughs have happened in the first 9 months of 2023 than all previous years from the turn of the century (2001 — 2022).

Will AGI kill us all? Will we join with it? Is it even close? Is it just “cool stuff”? Will we have bootstrapping self-improving AI?

The podcast crew today:
On the panel (left to right): Stefan Van Der Wel, Oliver Engelmann, Brendan Clarke.
Host camera: Roy Sherfan, Simon Carter.
Off camera: Peter Xing.

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Our solar system officially houses eight planets, but some scientists say there could be a ninth. And that’s not just Pluto aficionados – evidence suggests a huge undiscovered world lurks on the dark fringes out there. Now, a new study has found the outer solar system oddities could be explained by modified theories of gravity, an alternative idea to dark matter.

In the 19th century, astronomers measuring the orbit of Uranus noticed some inconsistencies between observations and predictions, and concluded that it was being influenced by the gravity of a large unseen body. Sure enough, the planet Neptune was soon discovered as a result.

In 2016 astronomers made a similar prediction: based on the bizarre orbital patterns of six icy objects in the Kuiper belt, an unknown planet with the mass of about 10 Earths could be tugging on them from the shadows. Further evidence from other objects and even the Sun’s tilt seemed to strengthen the case.

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A research team led by Prof. Yossi Paltiel at the Hebrew University of Jerusalem with groups from HUJI, Weizmann, and IST Austria recently conducted a study unveiling the significant influence of nuclear spin on biological activities. This discovery challenges long-held assumptions and opens up exciting possibilities for advancements in biotechnology and quantum biology.

Scientists have long believed that nuclear spin had no impact on biological processes. However, recent research has shown that certain isotopes behave differently due to their nuclear spin. The team focused on stable oxygen isotopes (16O, 17O, 18O) and found that nuclear spin significantly affects oxygen dynamics in chiral environments, particularly in its transport.

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