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Overcoming the resolution limit in a light microscope of around half a wavelength of light (about 250 nanometers) is one of the most significant developments in optics. Due to the wave nature of light, even the best lens cannot produce a light spot smaller than 250 nanometers in diameter. All molecules within this bright spot are illuminated at the same time, light up together, and therefore, appear inseparable as a blurred whole.

In the early 1990s, Stefan Hell realized that molecules could be separated by briefly switching the molecular signal “OFF” and “ON” in such a way that closely neighboring molecules are forced to signal consecutively. Molecules that signal consecutively can be readily distinguished.

In fluorescence microscopy, this ON/OFF separation principle could be implemented to perfection, since molecular fluorescence can be easily switched on and off. In fact, STED and PALM/STORM, as well as the more recent super-resolution fluorescence microscopes, are all based on this ON/OFF principle.

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Nanozymes are synthetic materials that have enzyme-like catalytic properties, and they are broadly used for biomedical purposes, such as disease diagnostics. However, inorganic nanozymes are generally toxic, expensive, and complicated to produce, making them unsuitable for the agricultural and food industries.

A University of Illinois Urbana-Champaign research team has developed organic-material-based nanozymes that are non-toxic, environmentally friendly, and cost-effective. In two new studies, they introduce next-generation organic nanozymes and explore a point-of-use platform for molecule detection in .

“The first generation of organic-compound-based (OC) nanozymes had some minor drawbacks, so our research group worked to make improvements. The previous OC nanozymes required the use of particle stabilizing polymers having repeatable functional groups, which assured stability of the nanozyme’s nanoscale framework, but didn’t achieve a sufficiently small particle size,” said lead author Dong Hoon Lee, who completed his Ph.D. from the Department of Agricultural and Biological Engineering (ABE), part of the College of Agricultural, Consumer and Environmental Sciences and The Grainger College of Engineering at the U. of I.

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A study led by UMass Chan Medical School researchers has demonstrated that a gene therapy to correct a mutation that causes maple syrup urine disease (MSUD) prevented newborn death, normalized growth, restored coordinated expression of the affected genes and stabilized biomarkers in a calf as well as in mice.

“Simply put, we believe the demonstrated in both animal species, especially in the cow, very well showcases the therapeutic potential for MSUD, in part because the diseased cow, without treatment, has a very similar metabolic profile as the patients,” said Dan Wang, Ph.D., assistant professor of genetic & cellular medicine.

Dr. Wang is co-principal investigator with Heather Gray-Edwards, DVM, Ph.D., assistant professor of genetic & cellular medicine; Guangping Gao, Ph.D., the Penelope Booth Rockwell Chair in Biomedical Research, director of the Horae Gene Therapy Center, director of the Li Weibo Institute for Rare Diseases Research and chair and professor of genetic & cellular medicine; and Kevin Strauss, MD, adjunct professor of pediatrics and head of therapeutic development at the Clinic for Special Children in Gordonville, Pennsylvania.

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The quantum rules shaping molecular collisions are now coming into focus, offering fresh insights for chemistry and materials science. When molecules collide with surfaces, a complex exchange of energy takes place between the molecule and the atoms composing the surface. But beneath this dizzying complexity, quantum mechanics, which celebrates its 100th anniversary this year, governs the process.

Quantum interference, in particular, plays a key role. It occurs when different pathways that a molecule can take overlap, resulting in specific patterns of interaction: some pathways amplify each other, while others cancel out entirely. This “dance of waves” affects how molecules exchange energy and momentum with surfaces, and ultimately how efficiently they react.

But until now, observing in collisions with heavier molecules like methane (CH4) was nearly impossible because of the overwhelming number of pathways available for the system to take en route to the different collision outcomes. Many scientists have even wondered if all quantum effects would always “wash out” for these processes so that the simpler laws of classical physics, which apply to everyday, “macroscopic” objects, might be enough to describe them.

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For the first time, researchers have used high-speed laser writing to create lines spaced just 100 nm apart on a glass substrate. The optimized printing approach could enable super-resolution 3D direct laser writing (DLW) of microlenses, photonics crystals, micro-optical devices, metamaterials and more.

DLW is an additive manufacturing technique that uses a focused laser beam to selectively solidify, or polymerize, a material with nanoscale precision. DLW typically uses multi-photon polymerization to polymerize materials in a precise, 3D manner.

“Increasing the —the minimum distance between two adjacent features—is difficult because the intense laser light can cause unwanted exposure in nearby areas during DLW,” said Qiulan Liu, a member of the research team from Zhejiang Lab and Zhejiang University in China. “However, by using a unique dual-beam optical setup and a special photoresist, we were able to overcome this challenge and achieve super-resolution DLW.”

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Chiral-structural-color materials produce color through microscopic structures that interact with light rather than through pigmentation or dyes. Some beetle exoskeletons, avian feathers, butterfly wings, and marine organisms feature these structures naturally, producing iridescent or polarization-dependent colors. Over the last 10–15 years, scientists have made progress in developing artificial chiral-structural-color materials.

Recently, Chinese researchers have made a breakthrough in the field by discovering that microdomes made from common polymers exhibit tunable chiral structural colors with broad-spectrum capabilities and multiple polarization-modulated chirality. This advancement could have significant implications for applications in displays, sensors, and .

Published in PNAS, the study was led by Prof. Li Mingzhu’s team from the Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences.

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Many next-generation quantum devices rely on single-photon emitters based on optically active defects in solids, known as color centers. Understanding their properties is fundamental to developing novel quantum technologies.

Now, in a study published in APL Materials, a multi-institutional research team led by Osaka University has sought to clarify the origin of the extremely bright color centers at the interface between (SiO2) and silicon carbide (SiC).

Previous research has demonstrated a range of factors that can play a role in the formation of these interface color centers, including the effect of annealing after oxidation. However, the energy level structure (i.e., the electronic transitions taking place) responsible for luminescence, a crucial factor for understanding the origin of color centers, was completely unknown.

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Researchers at Tohoku University, the University of Manchester, and Osaka University have made a breakthrough that has the potential to ignite the development of next-gen chiral information technology.

The findings are described in a study published in Proceedings of the National Academy of Sciences.

Chirality is a property of materials where their mirror image is not identical to the original—just like our left and right hands. This unique characteristic creates two distinct states, which researchers believe could one day be used to store , much like the “0” and “1” states in conventional computing.

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When you look at your surrounding environment, it might seem like you’re living on a flat plane. After all, this is why you can navigate a new city using a map: a flat piece of paper that represents all the places around you.

This is likely why some people in the past believed the Earth to be flat. But most people now know that is far from the truth.

You live on the surface of a giant sphere, like a beach ball the size of the Earth with a few bumps added. The surface of the sphere and the plane are two possible 2D spaces, meaning you can walk in two directions: north and south or east and west.

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Gravity shapes our universe, but could we one day shape gravity? Join us as we explore the possibilities of gravity technology, from artificial gravity and interstellar travel to terraforming and cosmic engineering.

Watch my exclusive video Big Alien Theory https://nebula.tv/videos/isaacarthur–… Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa… Use the link gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $30. Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Facebook Group: / 1,583,992,725,237,264 Reddit: / isaacarthur Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord Credits: Black Sun Rising: Living On A Planet Around A Black Hole Credits: Gravity Tech Episode 488; February 27, 2025 Written, Produced & Narrated by: Isaac Arthur Editor: Donagh Broderick Graphics: Jeremy Jozwik, LegionTech Studios, Sergio Botero Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Phase Shift, “Forest Night” Chris Zabriskie, “Unfoldment, Revealment”, “A New Day in a New Sector”, Stellardrone, “Red Giant”, “Billions and Billions“
Get Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur.
Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa…
Use the link gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $30.

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Credits:
Black Sun Rising: Living On A Planet Around A Black Hole.
Credits:
Gravity Tech.
Episode 488; February 27, 2025
Written, Produced & Narrated by: Isaac Arthur.
Editor: Donagh Broderick.
Graphics: Jeremy Jozwik, LegionTech Studios, Sergio Botero.

Select imagery/video supplied by Getty Images.

Continue reading “Gravity Tech: The Power To Reshape Our Civilization… And The Cosmos Themselves” | >