Lifeboat Foundation: Safeguarding Humanity
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Yang and co-workers state that “using inducible changes to the epigenome, we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that a loss of epigenetic information is a reversible cause of aging.” There is extensive evidence that the key reagent, restriction endonuclease I-PpoI, is cytotoxic. Moreover, the corresponding author published two papers—neither cited—showing that I-PpoI targeted to specific cell types causes a p53 response and cell elimination within a month. Despite globally inducing I-PpoI activation for seven times as long as required to induce a progeric effect, no analysis of mice during this critical window was presented. No significant conclusion of Yang was demonstrated.

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In the fascinating landscape tech realm, quantum computing stock opportunities could prove to be incredibly lucrative over time. The notion of quantum computing, born over two decades ago, is now gaining solid traction on The Street. Moreover, the technology, rooted in the mysteries of quantum mechanics, aims to boost computing speeds significantly.

The advancements in quantum computing are impossible to ignore, with continuous improvements and decreasing development costs. Moreover, the sector’s convergence with cloud computing opens doors for broader accessibility among researchers and software developers.

Furthermore, as the digital economy and artificial intelligence sectors grow, global spending on cloud computing is expected to reach a whopping $1 trillion annually within the next decade. Quantum computing appears to be on the cusp of becoming a game-changer, and it might be the most opportune time to load up on affordable quantum computing stocks.

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In Switzerland, there’s a new cryonics company: and they invited me to have a look around. I had questions: legal, practical, and ethical, and I want to be clear: this is not an endorsement. I just wasn’t going to turn down that invitation. ■ Tomorrow Bio: https://www.tomorrow.bio/

Camera: Martin Bäbler.

I’m at https://tomscott.com.
on Twitter at https://twitter.com/tomscott.
on Facebook at https://facebook.com/tomscott.
and on Instagram as tomscottgo.

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Anaplastic large cell lymphoma, a form of non-Hodgkin lymphoma, is the most common aggressive lymphoma in children. Chemotherapy and radiation fail to cure about 30% of cases. When tumors are driven by the oncogene ALK—which is the case for the majority of children—kinase inhibitor drugs like crizotinib are very effective in blocking tumor growth. They also lack the serious side effects of chemotherapy.

However, ALK inhibitors also very expensive—about $80,000 a year—and must be taken for a lifetime. As soon as they’re stopped, the lymphoma comes back. Roberto Chiarle, MD, a hematopathologist and researcher at Boston Children’s Hospital, wanted to know why.

“ALK inhibitors can control the lymphoma, but you cannot reach a cure,” he says. “Why do persist for so long?”

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Scientists have shown that a protein called NLRP11 has an essential role in the immune system; it alerts the body that a bacterial infection is occurring, triggering an immune response that battles the bacterial invader. NLRP11 appears to identify bacteria that are taken up by immune cells called macrophages, by recognizing a part of the bacterial coat. These findings have provided new insights into our understanding of the immune response to bacterial infection, and have been reported in Science Immunology.

The NLRP11 protein is expressed by humans, but not mice, which are a common animal model for infection. In this study, the researchers overcame that gap by using a mouse model that expressed a so-called humanized immune system. Humanized mice have been grafted with human cells and tissues so they replicate human biological functions more accurately.

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