Lifeboat Foundation

Tumor cells traverse many different types of fluids as they travel through the body. Christoph Burgstedt/Science Photo Library via Getty Images.

This article was originally featured on The Conversation.

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Even though the clinical efficacy of antibody-based therapeutics has been established, no methods that involve the de novo design of antibodies with wet lab validation are available.

About the study

A recent study, posted in the bioRxiv* preprint server, used generative AI models to develop de novo design antibodies against three distinct targets in a zero-shot fashion. A zero-shot designing method involves designing an antibody to bind to an antigen without follow-up optimization. The newly designed process has been termed de novo, meaning proteins (antibodies) were designed from first principles or from scratch.

In this interview, News Medical speaks to Assistant Professor Ryan Jackson about his latest work, published in tandem Nature papers, detailing the discovery of a new CRISPR immune system.

Please can you introduce yourself and tell us about your professional background?

I am an Assistant Professor at Utah State University (USU). I use biochemical and structural techniques to understand how the molecules that perform the reactions of life function. I’ve been working in the CRISPR field since 2011. I started as a postdoc in Blake Wiedenheft’s lab at Montana State University, and in 2016 I started my own research lab at USU. I earned both of my degrees (a B.S. in Biology and a Ph.D. in Biochemistry) from USU, so joining the faculty was like coming home. My research lab specializes in determining the structure and function of newly discovered and obscure CRISPR systems.

The FAA said normal operations were “resuming gradually” after ordering a nationwide pause on all domestic departures until 9 a.m. on Wednesday morning following a computer failure that has impacted flights around the country.

“The ground stop has been lifted,” officials said at about 8:50 a.m. ET. “We continue to look into the cause of the initial problem”

Departures were resuming at about 8:15 a.m. ET at two of the nation’s busiest hubs — Newark and Atlanta — FAA officials said on Twitter, adding, “We expect departures to resume at other airports at 9 a.m. ET.”

The difference between predictions and observations of the magnetic properties of muons suggests a mystery for the Standard Model.

Tech innovations such as artificial intelligence (AI), quantum computing, the metaverse, web3, and 5G are surrounded by so much hype and spin-doctoring that it can be difficult to get to the crux of things. Here, we try to cut through the hype.

Queen ants live far longer than genetically identical workers. Researchers are learning what their longevity secrets could mean for aging in other species.

Mosquitoes that transmit dengue and other viruses have evolved growing resistance to insecticides in parts of Asia, and novel ways to control them are desperately needed, new research warns.

Health authorities commonly fog mosquito-infested areas with clouds of insecticide, and resistance has long been a concern, but the scale of the problem was not well understood.

Japanese scientist Shinji Kasai and his team examined mosquitos from several countries in Asia as well as Ghana and found a series of mutations had made some virtually impervious to popular pyrethroid-based chemicals like permethrin.

I imagine, this could hurt a lot of people. This could easily be resolved with better ventilation and planning; not really outright banning.

A federal agency is considering a ban on gas stoves, a source of indoor pollution linked to childhood asthma.

In an interview with Bloomberg, a US Consumer Product Safety commissioner said gas stove usage is a “hidden hazard.”

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