A Japanese university said Friday it has successfully transplanted stem cells into a patient with a spinal cord injury, in the first clinical trial of its kind.
There is currently no effective treatment for paralysis caused by serious spinal cord injuries, believed to affect more than 100,000 people in Japan alone.
Surgeons at Tokyo’s Keio University want to study whether induced pluripotent stem (iPS) cells can be used to treat the injuries.
While it may be an unfamiliar sensation to humans, electroreception is relatively commonplace in the animal kingdom. Sharks, bees and even the platypus all share this ability to detect electric fields in their environment.
Scientists at UC Santa Barbara have just added fruit flies to that list. A team of researchers led by Matthieu Louis found that fruit fly larvae can sense electric fields and navigate toward the negative electric potential using a small set of sensory neurons in their head.
The findings, published in Current Biology, present an immense opportunity. Fruit flies are arguably the most commonly used experimental animals, the basis for studies in fields as disparate as genetics, neurobiology and aging. Uncovering electroreception in fruit flies opens new avenues of research into the basis of this sense and could even lead to new techniques in bioengineering.
At Stanford HAI, we believe AI is poised to be the most transformative technology of the 21st century. But its benefits won’t be evenly distributed unless we guide its development thoughtfully. The AI Index offers one of the most comprehensive, data-driven views of artificial intelligence. Recognized as a trusted resource by global media, governments, and leading companies, the AI Index equips policymakers, business leaders, and the public with rigorous, objective insights into AI’s technical progress, economic influence, and societal impact.
Lithium was introduced into psychiatric practice in the late nineteenth century and has since become a standard treatment for severe psychiatric disorders, particularly those characterized by psychotic agitation. It remains the most effective agent for managing acute mania and preventing relapses in bipolar disorder. Despite potential adverse effects, lithium’s use should be carefully considered relative to other treatment options, as these alternatives may present distinct safety and tolerability profiles. The World Health Organization classifies lithium salts as ‘essential’ medications for inclusion in global healthcare systems. Over the past two decades, the growing recognition of lithium’s efficacy—extending beyond mood stabilization to include reducing suicide risk and inducing neuroprotection—has led to its incorporation into clinical practice guidelines.
Microbial life has dominated Earth’s history but left a sparse fossil record, greatly hindering our understanding of evolution in deep time. However, bacterial metabolism has left signatures in the geochemical record, most conspicuously the Great Oxidation Event (GOE). We combine machine learning and phylogenetic reconciliation to infer ancestral bacterial transitions to aerobic lifestyles, linking them to the GOE to calibrate the bacterial time tree. Extant bacterial phyla trace their diversity to the Archaean and Proterozoic, and bacterial families prior to the Phanerozoic. We infer that most bacterial phyla were ancestrally anaerobic and adopted aerobic lifestyles after the GOE. However, in the cyanobacterial ancestor, aerobic metabolism likely predated the GOE, which may have facilitated the evolution of oxygenic photosynthesis.
University of Oregon chemists are bringing a greener way to make iron metal for steel production closer to reality, a step towards cleaning up an industry that’s one of the biggest contributors to carbon emissions worldwide. The research was published in ACS Energy Letters.
Last year, UO chemist Paul Kempler and his team reported a way to create iron with electrochemistry, using a series of chemical reactions that turn saltwater and iron oxide into pure iron metal.
In their latest work, they’ve optimized the starting materials for the process, identifying which kinds of iron oxides will make the chemical reactions the most cost-effective. That’s a key to making the process work at an industrial scale.
Although ADHD was originally considered to be a disorder of childhood, it has been clear for years that it also impacts adults. At least 60% of children diagnosed with ADHD struggle with symptoms into adulthood and the estimated prevalence of ADHD in adults is between 4 and 5%. As with children and teens, medication treatment is…
Now online! Inflammatory and anti-inflammatory cytokines act as neuromodulators to regulate anxiety levels via direct action on the same population of neurons in the amygdala of mice, underscoring the conservation of immune signaling and its receptor subunits in the brain.
Key to this innovation in ultrasound imaging—a method called Nonlinear sound sheet microscopy —was the discovery of a sound-reflecting probe. The author said: “This probe is a nanoscale gas-filled vesicle that lights up in ultrasound images, making cells visible. These vesicles have a protein shell and we can engineer them to tune their brightness in images. We used these gas vesicles to track cancer cells.”
In addition to revealing cells, the team used ultrasound and microbubbles as probes circulating in the blood stream to detect brain capillaries. The author said: “To our knowledge, nonlinear sound sheet microscopy is the first technique capable of observing capillaries in living brains. This breakthrough has tremendous potential to diagnose small vessel diseases in patients.” Since microbubble probes are already approved for human use, this technique could be deployed in hospitals in a few years.
Ultrasound is one of the most widely used imaging techniques in medicine, but up until recently it hardly played a role in imaging the tiniest structures of our bodies such as cells. “Clinical ultrasound, like the kind used for pregnancy scans, creates real-time images of body parts”, the first author explains. “It allows diagnosis of various diseases, or to monitor a developing baby. However, what is going on at a microscopic level remains hidden.”
Now, a team of scientists managed to image specifically labelled cells in 3D with ultrasound. For the first time, they imaged living cells inside whole organs across volumes the size of a sugar cube. In comparison, current light-based microscopes often require imaging of non-living samples, the author says. “The sample or organ of interest has to be removed and processed, and you lose the ability to track activity of cells over time”
Intracerebral haemorrhage is a subtype of stroke that is associated with poor outcomes. Ng et al. show in a preclinical study that CXC chemokine receptor 3
