Diabetes drugs may be doing more than managing blood sugar, they could also shape cancer biology in unexpected ways.
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On biological and artificial consciousness: A case for biological computationalism
The rapid advances in the capabilities of Large Language Models (LLMs) have galvanised public and scientific debates over whether artificial systems might one day be conscious. Prevailing optimism is often grounded in computational functionalism: the assumption that consciousness is determined solely by the right pattern of information processing, independent of the physical substrate. Opposing this, biological naturalism insists that conscious experience is fundamentally dependent on the concrete physical processes of living systems. Despite the centrality of these positions to the artificial consciousness debate, there is currently no coherent framework that explains how biological computation differs from digital computation, and why this difference might matter for consciousness.
BREAKING: Tesla Robotaxi DROPS Safety Monitors!
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Inside SpaceX’s Pre-IPO Share Buyback and Who Gets Access
SpaceX is preparing for a potential IPO by buying back shares from institutional holders and allowing existing shareholders to sell shares, while its affiliate company Tesla is making progress in autonomous driving technology with plans to launch robo-taxis in multiple cities ## Questions to inspire discussion.
SpaceX Investment Access.
🔐 Q: How can individual investors access SpaceX shares before the IPO?
A: Investors must be accredited with liquid net worth over $1M (excluding home) and can access shares through special purpose vehicles (SPVs) that charge upfront fees and 10% carry on returns.
💰 Q: What is the minimum investment required to buy SpaceX shares directly?
A: Direct SpaceX share purchases require $50M-$1B investments due to SEC’s 2,000 shareholder cap for private companies, making SPVs the only option for smaller investors.
Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase
Employing this sensitive assay, we revealed that the integration efficiencies of the 9.9-kb attP-containing DNA donor in rice cells remained remarkably high at 80.5%, relative to the 3.4-kb attP-containing donor, which was set as the baseline for 100% integration efficiency (Figure 2 B). However, a significant decrease in recombination efficiency was observed for donor DNA exceeding 17 kb. The integration efficiency of the 17.4-kb attP-containing plasmid decreased to 42.5% (Figure 2 B), and for the 27.3-kb attP-containing plasmid, it further declined to 8.2% (Figure 2 B). Similar trends were observed in Arabidopsis, with recombination efficiencies of 51.4%, 26.5%, and 9.0% for the 9.9-, 17.4-, and 27.3-kb attP-containing donors, respectively (Figure 2 C). Furthermore, PCR amplification of the attL junctions confirmed that the donor attP sequences had indeed been recombined into the attB as expected (Figures 2 D and 2E). Collectively, these results demonstrate that the Kp03 system can efficiently mediate targeted insertion of large DNA donors up to 27.3 kb in plant cells.
Interestingly, in addition to donor size, we also observed that Kp03-mediated recombination efficiency is sensitive to temperature, exhibiting differential efficiency under varying thermal conditions (Figure S2).
Cardiovascular Disease Biomarker Deep Dive (Test #7 In 2025)
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AI is solving ‘impossible’ math problems. Can it best the world’s top mathematicians?
Despite these potential limitations, Lackenby sees AI’s promise in mathematical hypothesis generation. “So many different areas of mathematics are connected to each other, but spotting new connections is really of interest and this process is a good way of seeing new connections that you couldn’t see before,” he said.
Lackenby’s work demonstrates that AI can be helpful in suggesting conjectures that mathematicians can then go on to prove. And despite Saunders’ reservations, Tao thinks AI could be useful in proving existing conjectures.
The most immediate payoff might not be in tackling the hardest problems but in picking off the lowest-hanging fruit, Tao said.
