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Single-cell maps show chemokine signals collapse as aggressive lymphoma spreads

Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections and tumors. For these processes to function properly, immune cells (B cells and T cells) must be organized in a precise spatial pattern in the lymph node tissue, for example in so-called B cell follicles and T cell zones. They are controlled by stromal cells (non-hematopoietic structural cells). They release messenger substances called chemokines, creating signals to guide the immune cells to their designated positions in the lymph node.

In the case of B cell lymphomas, the internal structure of the lymph node tissue can be disturbed in very different ways, depending on the exact type of lymphoma: While the fundamental tissue structure remains intact in the case of slow-growing lymphomas such as follicular lymphoma (FL), aggressive lymphomas such as diffuse large B cell lymphoma (DLBCL) cause the tissue structure to break down completely. Why these typical growth patterns develop has been largely unclear to date.

In the study “Architectural principles of lymphoma-induced lymph node tissue remodeling,” the researchers coordinated by Professor Dietrich (Director of the Department of Hematology, Oncology and Clinical Immunology, UKD) have now succeeded in systematically mapping these processes in the human lymph node for the first time. By means of single-cell analyses and spatial tissue mapping, they were able to trace which factors lead to the progressive breakdown of the lymph node architecture in the case of lymphoma. The work is published in the journal Nature Cancer.

Listeria-infected macrophages promote biomechanical alterations in endothelial cell monolayers for transmigration

Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers and spread systemically. Muenkel et al. show that exposure to infected macrophages weakens contractile forces within the endothelial monolayer and promotes macrophage transmigration. This response is driven by direct cell-cell interactions, with cytokines exerting only minor and transient effects.

First microlasers capable of detecting individual molecules and ions could one day aid diagnosis

Scientists have created the first microlasers capable of detecting individual molecules and even single atomic ions, a breakthrough that could significantly advance early disease diagnosis and molecular-scale medical testing. Researchers at the University of Exeter’s Living Systems Institute have published their work in Nature Photonics. The paper opens up new possibilities for microlaser biosensing technology, including “lab-on-a-chip” technology capable of instant medical testing and diagnosis.

Microlasers are tiny glass beads measuring around just 0.1 mm (the width of a human hair) to 0.01 mm (the length of a single bacterium). With a central cavity that acts as a tiny mirror, they emit and bounce light in a circular motion around the bead. This circular path of trapped light is known as whispering gallery modes (WGM) laser technology.

Light continuously circulates around the sphere’s inner boundary, enabling the device to detect extremely small disturbances on its surface. Previous research has shown that such microlasers can even be inserted into living cells, acting as optical barcodes to track cellular movement inside organisms.

Microsoft-backed start-up raises $40 million for helium atom beam lithography that could print chips at atomic resolution — 0.1nm beam is 135 times narrower than ASML’s EUV light

Lace Lithography, a Norwegian start-up backed by Microsoft, raised $40 million in Series A funding on Monday to develop a chipmaking tool that uses a helium atom beam instead of light to pattern silicon wafers, Reuters reported. The company claims its technology can create chip features 10 times smaller than current lithography systems, with a beam width of just 0.1 nanometers compared to the 13.5nm wavelength used by ASML’s EUV scanners. Lace aims to have a test tool running in a pilot fab by 2029.

The advantage of Lace’s system is that atoms don’t have a diffraction limit, whereas photon-based lithography, including ASML’s EUV systems, is constrained by the wavelength of the light it uses. As chipmakers push features smaller, they rely on increasingly complex multi-patterning techniques to work around that limit, but Lace sidesteps the problem entirely by replacing photons with neutral helium atoms and a beam measuring roughly the width of a single hydrogen atom.

Teleportation is no longer just science fiction—at the quantum level

(Science fiction’s “warp drive” is speeding closer to reality.)

Inspired by science fiction, they landed on “quantum teleportation.” Since then, the idea has gone from theoretical concept to an experimentally verified reality. The first experiments in the late 1990s showed that quantum states could be transmitted across short distances, while subsequent research proved it works across increasingly longer distances—even to and from low Earth orbit, as Chinese scientists demonstrated in 2017. They’ve achieved quantum teleportation by taking advantage of quantum entanglement, a natural phenomenon in which tiny particles can become linked with each other across infinite distances.

Quantum teleportation is very different from the teleportation of matter we see in fiction. It involves transferring a quantum state without moving any matter. And while experts say it won’t lead to Star Trek-esque beaming, it could help bring about a new era of computing that revolutionizes our understanding of the subatomic world—and by extension, of the nature of the universe and everything within it.

Your clothes may become smarter than you

You’re probably used to the sight of smartwatches on people’s wrists. But what about smart clothes? Researchers at the University of Georgia are exploring how the clothes people wear can potentially track and protect their health. Smart textiles are fabrics that can monitor the body’s vitals and movement in real time. They’re flexible and lightweight, making them more comfortable to wear while moving.

The present publication focuses on MXenes, a class of two-dimensional, microscopic materials made from metals that can be coated or printed onto fabrics. The researchers conducted a comprehensive analysis of hundreds of published studies to examine the different properties of MXenes and how they could be used in smart textiles. The paper is published in the journal ACS Omega.

“MXenes have some advanced properties,” said Joyjit Ghosh, corresponding author of the study and a doctoral student in UGA’s College of Family and Consumer Sciences. Not only can they detect body temperature, blood pressure and heart rate, he said, but they are also antimicrobial, making them ideal for hospital settings.

Scientists successfully harvest chickpeas from ‘moon dirt’

As the U.S. plans to return to the moon with the upcoming Artemis II mission, a question endures: What will future lunar explorers eat? According to new research from The University of Texas at Austin, the answer might be chickpeas.

Scientists have successfully grown and harvested chickpeas using simulated “moon dirt,” the first instance of this crop produced in this medium. The research, which was conducted in collaboration with Texas A&M University, is described in a paper published in the journal Scientific Reports.

Sara Santos, the principal investigator of the project, said that the work is a giant leap in understanding what it will take to grow food on the lunar surface.

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