Stanford researchers observed individual phonons, or quantum units of sound, making discrete energy jumps in a mechanical resonator.
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Insilico Medicine AI Drug Rentosertib Cuts Biological Age on Six Independent Protein Clocks
Didn’t say by how much unless I skimmed over it.
Not proven yet. The study found a coordinated shift in blood proteins associated with younger predicted biological age in treated IPF patients. It cannot prove the drug reversed the aging process itself, because all study participants had IPF — a disease that alters the very protein patterns the clocks are trained on. The critical next test, which Nobel laureate Michael Levitt explicitly named, is a trial in healthy volunteers without IPF. If the biological age signal persists in people without the disease confound, the case for systemic geroprotective activity becomes substantially stronger. The ongoing Phase III trial in IPF (320 patients, 47 centers in China) is designed to assess lung function, not aging per se — but its larger sample may provide additional proteomic data over a longer time horizon.
What makes rentosertib different from other longevity drugs like rapamycin or metformin?
Rapamycin, metformin, and the senolytic combination dasatinib plus quercetin are repurposed drugs: they were developed for other indications (organ transplant, diabetes, and cancer, respectively) and discovered through subsequent research to interact with aging-relevant pathways. None was designed with aging biology as the primary specification. Rentosertib was. Insilico’s AI platform scored TNIK — the drug’s molecular target — against the 12 hallmarks of aging framework, found it relevant to six hallmarks, and designed a molecule specifically to inhibit it. That makes rentosertib, if its geroprotective effects are confirmed in further studies, the first drug created from scratch specifically for the biology of aging to produce a clinical signal in humans.
AI Pioneer Andrew Ng Calls Extinction Fears ‘Science Fiction’
Artificial intelligence pioneer Andrew Ng said warnings about existential AI risks from researchers at top model makers are “science fiction” that may be detrimental to ensuring the technology’s maximum benefits to society.
Ng, who helped start Google Brain and Coursera Inc., said the tech industry previously stoked fears about the potential catastrophic harms of artificial intelligence earlier in the AI boom in an apparent bid to bolster publicity and shape regulation.
A single IV treatment retrains immune cells to fight autoimmune diseases in early trial
CAR T-cell therapy is an immune-reprogramming procedure that turns a patient’s own immune cells into cancer-fighting specialists. The entire process is complex, but researchers have now found a faster way to achieve similar effects using a single intravenous (IV) drip of a harmless engineered virus.
Scientists discover cells that cheat death and rebuild damaged tissue
Scientists discovered a population of cells that can start the process of programmed cell death, survive it, and then help rapidly rebuild damaged tissue. Their descendants become far more resistant to future damage, revealing a mechanism that could improve healing but may also help cancers return after treatment.
Longitudinal dynamics of gene expression and metabolomics in an aging population cohort
Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudinal whole-blood gene expression and metabolite levels in 335 females over 8 years. Levels of 5,061 genes and 181 metabolites changed over time, with individual trajectories often diverging from population-level trends. Longitudinally variable genes showed cell type specificity and enrichment for aging-relevant pathways, including cardiometabolic and neurodegenerative disorders. Longitudinal trajectories were further shaped by genetics, circadian rhythm, seasonality, and environmental pollutant exposures. Integrative analyses revealed extensive static and time-variable cross-omic connectivity.
Group raises awareness of brain aneurysm signs as survivor shares story
Brain aneurysms can be fatal and sometimes debilitating, and, in most cases, there are not many ways to prevent them. But a local group is working to raise awareness about the warning signs and symptoms.
For Carly Nunn, surviving a brain aneurysm has been a long road.
“I was very, very scared, afraid, not knowing what was happening,” Nunn said.
Eight years ago, Nunn was a college student at the University of Cincinnati when she began to feel something was wrong.
“I started feeling kind of off and weird, and it eventually led to me losing all feeling in the right side of my body,” she said.
Nunn said her roommate, a nursing student, acted quickly to get her medical help.
Two years ago, I went on the NoCode podcast and spent an hour telling builders the tools aren’t the point
JJ Englert and David Pal invited me on This Week in NoCode, expecting a conversation about #AI. They got one about character, culture, and who gets to decide the Why.
Somewhere in there I argued that the biggest project of our civilization is humanity itself, and that we keep pouring money into intelligence while starving wisdom. Two years, a few hundred billion in capex, and one full hype cycle later, I’d only say it louder.
There’s a stretch in the middle on self-regulation and #ethics that I’d rather you watch than have me paraphrase here.
The Future of Humanity and AI with Nikola Danaylov: A Deep Dive into Ethics, Culture, and Technology [ https://snglrty.co/49Sb8aE](https://snglrty.co/49Sb8aE)
Nikola Danaylov on the ethical and cultural challenges of AI, emphasizing the balance of human wisdom with technological advancements.