Researchers from Ruhr University Bochum have partnered with colleagues in Göttingen, Berlin, Paris and Essen to develop new optogenetic tools that can selectively inhibit cellular activity through light. These tools could help investigate diseases in which the balance between excitation and inhibition is disrupted, such as cardiac arrhythmias.
The team working alongside Dr. Brix Mücher, Dr. Ida Siveke and professor Stefan Herlitze from the Department of General Zoology and Neurobiology at Ruhr University Bochum, Germany, reports its findings in the journal Science Signaling on Oct. 20, 2026.
Optogenetic tools can be used to activate and deactivate nerve cells via light. In their present study, the researchers coupled a light-sensitive receptor named Opn4L to a modified potassium channel named GIRK1, which activates a G-protein-coupled signaling pathway.








