Nvidia said it had 0% market share in China mere months ago.
Get the latest international news and world events from around the world.
Gene Therapy for Parkinson’s Disease Associated with GBA1 Mutations
Abeliovich et al. make a compelling case for the promise of using gene therapy to treat Parkinson’s disease (PD) patients who possess mutations in the GBA1 gene. People interested in the clinical-translational side of biomedicine should definitely check this out!
This website uses a security service to protect against malicious bots. This page is displayed while the website verifies you are not a bot.
Dyno Therapeutics Launches Two New AAV Capsids and AI Platform for Rare Disease Therapeutic Development at the 2026 American Society of Gene & Cell Therapy (ASGCT) Annual Meeting
Dyno continues to develop impressive new AAV capsids with their AI-guided design approach!
About Dyno Therapeutics.
Dyno Therapeutics is on a mission to build high-performance genetic technologies that transform patients’ lives. Dyno applies AI to build technologies for gene delivery and sequence design that advance “Genetic Agency” — an individual’s ability to take action at the genetic level to live a healthier life — through safe, effective and widely accessible genetic treatments. With frontier AI models and high-throughput in vivo experimentation, Dyno designs optimized AAV delivery vectors that solve gene delivery challenges across a wide range of therapeutic applications including eye, muscle and CNS. Dyno partners across industries to ensure these life-transforming technologies can help as many patients as possible, including through strategic collaborations with leading gene therapy developers Astellas and Roche and with technology companies including NVIDIA. Dyno’s AI-designed capsids are available for direct licensing and through the Dyno Frontiers Network. Visit www.dynotx.com for more information.
‘Dyno Therapeutics’, ‘dyno’, the Dyno logo, and mountain logo are registered trademarks of Dyno Therapeutics, Inc. All rights reserved.
Law of the iterated logarithm
Where “log” is the natural logarithm, “lim sup” denotes the limit superior, and “a.s.” stands for “almost surely”. [ 3 ] [ 4 ]
Another statement given by A. N. Kolmogorov in 1929 [ 2 ] is as follows.
Roles of lysosomal small-molecule transporters in metabolism and signaling
Small-molecule transporters of the lysosomal membrane export lysosomal catabolites for reuse in cell metabolism.
These transporters often show substrate promiscuity and, conversely, a given metabolite is often exported through distinct transport routes and sometimes in different states (e.g., single amino acids versus dipeptides).
Some lysosomal transporters import metabolites into the lumen. The combination of importers and exporters can create small-molecule shuttles across the lysosomal membrane, which regulate the lumen state.
Some lysosomal transporters participate in intracellular signaling cascades. sciencenewshighlights ScienceMission https://sciencemission.com/lysosomal-small-molecule-transporters
Lysosomes degrade damaged or unwanted cell/tissue components and recycle their building blocks through small-molecule transporters of the lysosomal membrane. They also act as signaling hubs that sense and signal internal cues, such as amino acids, to coordinate cell responses. Recently, the activity of several lysosomal metabolite transporters has been elucidated, bringing new insights into lysosomal functions. Cell biological and structural studies of lysosomal transporters have also highlighted their roles in recruiting signaling complexes to lysosomes and delineated how their substrates gate such hybrid transporter/receptor, or ‘transceptor’, function.
Quobly Toolbox Explores Quantum Phase Estimation Pipeline With Tensor Networks
An international collaboration between a French quantum startup and a major Taiwanese electronics manufacturer has yielded a new open-source tool for exploring a critical area of quantum computing. Quobly and Taiwan’s Hon Hai Research Institute, the R&D arm of Foxconn, jointly released a numerical toolbox dedicated to the Quantum Phase Estimation (QPE) algorithm, described as a cornerstone of fault-tolerant quantum computing with major applications in quantum chemistry and materials science. While QPE’s theoretical benefits are understood, simulating its practical resource needs has proven difficult; the toolbox aims to bridge this gap by allowing researchers to explore implementations and their implications. The tool focuses on practical, interpretable numerical experiments, enabling full circuit executions for up to 20 qubits and circuits ranging from 1,000 to 100,000 gates on standard laptops.
Quantum Phase Estimation Toolbox for Molecular Systems
While the theoretical underpinnings of QPE are well established, simulating its practical demands has proven a significant hurdle, limiting exploration beyond simplified models. The toolbox addresses this gap by offering a platform for practical, interpretable numerical experiments, allowing scientists to investigate QPE implementations without requiring access to full-scale quantum hardware, which is currently unavailable. Built upon advanced tensor network techniques and the open-source quimb library, the toolbox facilitates the preparation of initial states using DMRG and matrix product states, and allows encoding of molecular Hamiltonians into quantum circuits through methods like trotterization and qubitization. Researchers can directly compare standard QPE with the single-ancilla Robust Phase Estimation (RPE) method, analyzing circuit depth, gate counts, and potential error sources.
A fresh approach to peppermint: 250 new variants could boost flavor and fight disease
The genomics of peppermint are not as fresh as their flavor but scientists from the University of California, Davis, have found a way to breathe new genetic variation into the species. The findings, published in the Proceedings of the National Academy of Sciences, could help the mint industry develop new varieties of peppermint and provide a roadmap for improving clonal crops more generally.
Similar to strawberries, potatoes and many fruit trees, peppermint plants (Mentha × piperita) are reproduced asexually by a process called clonal propagation. In the case of peppermint, this means that their genomes have remained unaltered for more than 200 years. This lack of genetic variation leaves them susceptible to disease and means that properties such as yield and flavor have remained stagnant.
UC Davis plant biologists used radiation to induce mutations in the leading peppermint clone grown in the United States, resulting in more than 250 new and genetically distinct variants. Altogether, they introduced 1,406 large genetic mutations, which can now be used to identify key genes for breeding or selecting new and superior peppermint varieties.
Webb discovers one of the universe’s first galaxies
Scientists have discovered a galaxy as it was 13 billion years ago, 800 million years after the Big Bang. It contains possible evidence of the universe’s first stars and is one of the most chemically primitive galaxies observed to date.
The first stars and galaxies are difficult to see because they are so far away and their light is extremely faint. But thanks to the James Webb Space Telescope, we don’t have to remain in the dark about them. This $10 billion observatory was launched in 2021 and can peer back in time to when the first galaxies and stars were forming.
In a paper published in the journal Nature, a team of scientists led by Kimihiko Nakajima, an astronomer at Kanazawa University, Japan, describes how they used the telescope to study a part of the deep universe and discovered a faint galaxy called LAP1-B. “LAP1-B establishes a ‘fossil in the making,’ a direct high-redshift progenitor of the ancient ultra-faint dwarf galaxies observed in the local universe,” they wrote.