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Groundbreaking Study Identifies Four Biologically Distinct Autism Subtypes

Autism reveals multiple biological subtypes, each with unique genetic and developmental patterns. Researchers from Princeton University and the Simons Foundation have discovered four autism subtypes that are both clinically and biologically distinct. This breakthrough offers a deeper understandin

Kinase enzymes exist throughout tree of life—those found in bacteria may be vulnerable targets for new antibiotics

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have developed an atlas of bacterial kinases and say their new compendium holds a motherlode of possible targets for reimagined antimicrobial drugs.

A team of researchers at the University of Georgia has zeroed in on serine-threonine , regulators of cell growth and pathogenicity in a multitude of bacterial species. They say their compendium can provide guidance on research into bacterial virulence and potentially trailblazing ways to attack bacteria by inhibiting the activity of serine-threonine kinases. The team’s compendium was developed by analyzing serine-threonine kinases in nearly 26,000 strains of bacteria.

“Bacterial serine-threonine kinases regulate diverse cellular processes associated with , virulence, and pathogenicity and are evolutionarily related to the druggable eukaryotic serine-threonine kinases,” writes researcher Dr. Brady O’Boyle of the University of Georgia, lead author of the new study involving the massive atlas. O’Boyle and his team found that the number of serine-threonine kinases within bacterial genomes ranges from 1 in Escherichia coli to more than 60 in some species of Actinobacteria.

Archaeologists uncover lavish Bronze Age burial of young woman in Greater Khorasan

A study by Ali Vahdati and his colleagues, Raffaele Biscone, Roberto Dan, and Marie-Claude Trémouille analyzed the remains and artifacts contained in the richest burial ever excavated from the Greater Khorasan Civilization (GKC) site of Tepe Chalow.

A bolt is born: Atmospheric events underpinning lightning strikes explained

Though scientists have long understood how lightning strikes, the precise atmospheric events that trigger it within thunderclouds have remained a perplexing mystery. The mystery may now be solved, thanks to a team of researchers led by Victor Pasko, professor of electrical engineering in the Penn State School of Electrical Engineering and Computer Science, that has revealed the powerful chain reaction that triggers lightning.

Marathon Fusion claims it can turn mercury into gold while creating clean energy

A startup energy company, called Marathon Fusion, may soon be living out the dream of alchemists from the Middle Ages. In a recently released paper posted to the arXiv preprint server, the company outlines a method to turn an isotope of mercury, 198Hg, into 197Au, the most stable form of gold.