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Engineered protein can turn off tissue-damaging immune cells in autoimmune diseases

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.

In these autoimmune diseases, T cells mistakenly target the body’s own tissues instead of invading viruses or bacteria as they would during normal immune responses. Treatments focused on T cells have been elusive because blocking their action broadly weakens the immune system and creates risk for infections and cancer.

Published online June 30 in the journal Cell, the study revealed that holding closely together two protein groups (signaling complexes) on T cells, including one found more often on T cells involved in autoimmune disease, shuts down those T cells in a limited way.

Unknown organelle inside our cells discovered!

The discovery of an unknown organelle inside our cells could open the door to new treatments for devastating inherited diseases.

The organelle, a type of specialized structure, has been dubbed a “hemifusome” by its discoverers. This little organelle has a big job helping our cells sort, recycle and discard important cargo within themselves, the scientists say. The new discovery could help scientists better understand what goes wrong in genetic conditions that disrupt these essential housekeeping functions.

One such condition is Hermansky-Pudlak syndrome, a rare genetic disorder that can cause albinism, vision problems, lung disease and issues with blood clotting. Problems with how cells handle cargo are at the root of many such disorders.

The scientists believe hemifusomes facilitate the formation of vesicles, tiny blister-like sacs that act as mixing bowls, and of organelles made up of multiple vesicles. This process is critical to cellular sorting, recycling and debris disposal, the researchers report.

Tiny light-sensitive magnetic robots can clear up bacterial infections in sinuses

Tiny magnetic bots that are activated by light can clear bacterial infections deep in the sinus cavities, then be expelled by blowing out the nose.

A new study published in Science Robotics unveiled copper single–atom–doped bismuth oxoiodide microbots, each smaller than a grain of salt, that can be tracked and guided to the location of infection via X-ray imaging, thus providing a precise, minimally invasive therapeutic strategy for managing clinically.

Sinusitis is a common respiratory condition often linked to biofilm produced by bacteria like Streptococcus pyogenes. This condition causes inflammation of the sinus lining and leads to symptoms such as , reduced sense of smell, facial pain, and, in some dire cases, even memory impairment.

Exploring late accretion’s role in terrestrial planet evolution

Southwest Research Institute has collaborated with Yale University to summarize the scientific community’s notable progress in advancing the understanding of the formation and evolution of the inner rocky planets, the so-called terrestrial planets. Their paper focuses on late accretion’s role in the long-term evolution of terrestrial planets, including their distinct geophysical and chemical properties as well as their potential habitability.

The Review paper is published in the journal Nature.

Solar systems form when clouds of gas and dust begin to coalesce. Gravity pulls these elements together, forming a central star, like our sun, surrounded by a flattened disk of consolidating materials. Our terrestrial planets—Mercury, Venus, Earth and Mars—formed as smaller rocky objects accumulated, or accreted, into larger planetesimals and eventually protoplanets, when late impacts made critical contributions. Earth was probably the last terrestrial planet to form, reaching about 99% of its final mass within about 60–100 million years after the first solids began to consolidate.

Rerouted bile acid thwarts tumor spread in colorectal cancer mouse model

Research led by the Department of General and Visceral Surgery, Faculty of Medicine, University of Freiburg, Germany has found that bile acid diversion in Roux-en-Y gastric bypass (RYGB) reduces colorectal tumor growth and metastasis independent of weight loss, potentially reshaping future cancer treatment approaches.

More than 2 billion adults worldwide are now overweight or obese, a condition marked by chronic low-grade inflammation and metabolic disruption that can promote tumor growth, increasing the risk of developing at least 15 types of cancer. In the United States alone, more than a third of adults face obesity, presenting an urgent public-health crisis.

Among various weight-loss interventions, , specifically RYGB, is not only effective in promoting sustained weight reduction but has intriguingly been linked to reduced cancer incidence. Whether these changes alone can slow or prevent colorectal cancer remains a question with critical implications for prevention and treatment.

Subtle molecular changes in brain cells may be linked to autism and schizophrenia

A team of researchers at NYU Abu Dhabi has uncovered a key mechanism that helps shape how our brains are wired, and what can happen when that process is disrupted.

In a new study published in Cell Reports, the RNA-MIND Lab at NYU Abu Dhabi, led by Professor of Biology Dan Ohtan Wang, with Research Associate Belal Shohayeb, reveals how a small molecular mark on messenger RNA, called m6A methylation, regulates the production of essential proteins inside growing neurons. This process plays a critical role in the development of axons, the long extensions that neurons use to connect and communicate with each other.

The study shows that this molecular mark controls the production of a protein called (APC), which helps organize the internal structure of nerve cells and is needed to locally produce β-actin, a key building block of the cytoskeleton to support axon growth. Importantly, the team also found that linked to autism and schizophrenia can interfere with this process, potentially affecting how the brain develops.

New superheavy isotope reveals complex relationship between quantum effects and fission

In a study published in Physical Review Letters, scientists at GSI Helmholtzzentrum für Schwerionenforschung have discovered a new superheavy isotope, 257 Sg (seaborgium), whose properties are providing new insights into nuclear stability and fission in the heaviest elements.

Superheavy elements exist in a delicate balance between the attractive nuclear force that holds protons and neutrons together and the repulsive electromagnetic force that pushes positively charged protons apart.

Without quantum shell effects, analogous to electron shells in atoms, these massive nuclei would split apart in less than a trillionth of a second.

Analysis provides day-by-day insight into prehistoric plankton’s capacity for change

Scientists at the University of Southampton have developed a new way of analyzing fossils, allowing them to see how creatures from millions of years ago were shaped by their environment on a day-to-day basis for the first time.

The research, published in Proceedings of the National Academy of Sciences, could improve our understanding of how character traits driven by shaped evolutionary history and life on Earth.

It could help scientists to understand how much of a species’ evolutionary journey is down to “nature vs. nurture.”

Engineering nano-clouds that can change color, temperature and outwit heat sensors

How does a cloud stay cool under direct sunlight––or seem to vanish in infrared? In nature, phenomena like white cumulus clouds, gray storm systems, and even the hollow hairs of polar bears offer remarkable lessons in balancing temperature, color and invisibility. Inspired by these atmospheric marvels, researchers have now created a nanoscale “cloud” metasurface capable of dynamically switching between white and gray states—cooling or heating on demand––all while evading thermal detection.