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Biphenomycin biosynthetic pathway decoded, opening door to new antibiotic development

Biphenomycins, natural products derived from bacteria, show excellent antimicrobial activity, but have long remained out of reach for drug development. The main obstacle was the limited understanding of how these compounds are produced by their microbial hosts.

A research team led by Tobias Gulder, department head at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), has now deciphered the biosynthetic pathway of the biphenomycins, establishing the foundation for their pharmaceutical advancement. The team published its findings in the journal Angewandte Chemie International Edition.

Chip-scale magnetometer uses light for high-precision magnetic sensing

Researchers have developed a precision magnetometer based on a special material that changes optical properties in response to a magnetic field. The device, which is integrated onto a chip, could benefit space missions, navigation and biomedical applications.

High-precision magnetometers are used to measure the strength and direction of magnetic fields for various applications. However, many of today’s magnetometers must operate at extremely low temperatures—close to 0 kelvin—or require relatively large and heavy apparatus, which significantly restricts their practicality.

“Our device operates at room temperature and can be fully integrated onto a chip,” said Paolo Pintus from the University of California, Santa Barbara (UCSB) and the University of Cagliari, Italy, co-principal investigator for the study. “The light weight and low power consumption of this magnetometer make it ideal for use on small satellites, where it could enable studies of the magnetic areas around planets or aid in characterizing foreign metallic objects in space.”

Transistor ‘design limitation’ actually improves performance, scientists find

What many engineers once saw as a flaw in organic electronics could actually make these devices more stable and reliable, according to new research from the University of Surrey and Joanneum Research Materials.

The paper, which will be presented at the IEEE International Electron Devices Meeting (IEDM) 2025, describes how embracing small energy barriers at the metal/semiconductor interface of organic thin-film transistors (OTFTs) can help them perform more consistently and operate more reliably over time.

Organic thin-film transistors (OTFTs) are a key component of what are thought to be the next generation of flexible and wearable electronics. They are lightweight, low-cost and printable on large areas, but their long-term stability has been a persistent challenge.

Colloidal quantum dot photodiodes integrated on metasurfaces for compact SWIR sensors

This week, at the IEEE International Electron Devices Meeting (IEDM 2025), imec, a research and innovation hub in advanced semiconductor technologies, successfully demonstrated the integration of colloidal quantum dot photodiodes (QDPDs) on metasurfaces developed on its 300 mm CMOS pilot line. This pioneering approach enables a scalable platform for the development of compact, miniaturized shortwave infrared (SWIR) spectral sensors, setting a new standard for cost-effective and high-resolution spectral imaging solutions.

Short-wave infrared (SWIR) sensors offer unique capabilities. By detecting wavelengths beyond the visible spectrum, they can reveal contrasts and features invisible to the human eye and can therefore see through certain materials such as plastics or fabrics, or challenging conditions like haze and smoke. Conventional SWIR sensors remain, however, expensive, bulky, and challenging to manufacture, restricting their use to niche applications.

Quantum dot (QD) image sensors, a new class of SWIR sensors, offer a promising alternative, combining lower cost with higher resolution. So far, however, they have operated in broadband rather than in spectral mode.

Radiofrequency upgrades ensure accelerator stability and reliability

Running a synchrotron light source is a massive team effort that brings hundreds of highly skilled and specialized professionals together. The radiofrequency (RF) group at the National Synchrotron Light Source II (NSLS-II), a U.S. Department of Energy (DOE) Office of Science user facility at DOE’s Brookhaven National Laboratory, plays an integral role in synchrotron operations. The work they do, often behind the scenes, ensures that the electron beam that enables cutting-edge science at NSLS-II remains bright, powerful, and stable.

The electrons that circle through NSLS-II’s nearly half-mile-long storage ring lose energy as they produce X-rays, which scientists use to perform a variety of experiments at the facility. To keep the beam moving steadily, the electrons pass through hollow RF cavities. These cavities, tuned to a precise frequency, restore the electrons’ energy each time they pass through.

When cooled to cryogenic temperatures, the material that the cavities are comprised of, niobium, takes on superconducting properties that nearly eliminate electrical resistance and drastically improve energy efficiency and beam stability. The design also allows unwanted high-frequency oscillations to be safely damped, ensuring a stable, high-intensity X-ray beam.

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