Researchers at The Ohio State University Wexner Medical Center and College of Medicine have discovered a new way that neurons act in neurodegeneration by using human neural organoids—also known as “mini-brain” models—from patients with frontotemporal lobar degeneration (FTLD).
Understanding this new pathway could help researchers find better treatments for FTLD and Alzheimer’s, the two most common forms of dementia that lead to cognitive decline.
Researchers used advanced techniques to study neurons from patients and mice, including growing human neural organoids (mini-brains) that can feature several cell types found in the brain.