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What’s The Biochemistry Of Fitness In 80yr Olds?

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Prediabetes remission possible without dropping pounds, new study finds

There’s a long-held belief in diabetes prevention that weight loss is the main way to lower disease risk. Our new study challenges this.

For decades, people diagnosed with prediabetes—a condition affecting up to one in three adults depending on age—have been told the same thing by their doctors: eat healthily and lose weight to avoid developing diabetes.

This approach hasn’t been working for all. Despite unchanged medical recommendations for more than 20 years, diabetes prevalence continues rising globally. Most people with prediabetes find weight-loss goals hard to reach, leaving them discouraged and still at high risk of diabetes.

Fundamental engineering principles can help identify disease biomarkers more quickly

People often compare the genome to a computer’s program, with the cell using its genetic code to process environmental inputs and produce appropriate responses.

But the machine metaphor can be extended even further to any , and applying established concepts of engineering to biology could revolutionize how scientists make their observations within biology, according to research from University of Michigan.

In a paper published in Proceedings of the National Academy of Sciences, Indika Rajapakse, Ph.D., Joshua Pickard, Ph.D. (now an Eric and Wendy Schmidt Postdoctoral Fellow at the Broad Institute), and their team propose that fundamental principles of and observability can be applied to study that change over time.

Six billion tonnes a second: Rogue planet found growing at record rate

Astronomers have identified an enormous ‘growth spurt’ in a so-called rogue planet. Unlike the planets in our Solar System, these objects do not orbit stars, free-floating on their own instead. The new observations, made with the European Southern Observatory’s Very Large Telescope (ESO’s VLT), reveal that this free-floating planet is eating up gas and dust from its surroundings at a rate of six billion tonnes a second. This is the strongest growth rate ever recorded for a rogue planet, or a planet of any kind, providing valuable insights into how they form and grow.

People may think of planets as quiet and stable worlds, but with this discovery we see that planetary-mass objects freely floating in space can be exciting places,” says Víctor Almendros-Abad, an astronomer at the Astronomical Observatory of Palermo, National Institute for Astrophysics (INAF), Italy and lead author of the new study.

The newly studied object, which has a mass five to 10 times the mass of Jupiter, is located about 620 light-years away in the constellation Chamaeleon. Officially named Cha 1107–7626, this rogue planet is still forming and is fed by a surrounding disc of gas and dust. This material constantly falls onto the free-floating planet, a process known as accretion. However, the team led by Almendros-Abad has now found that the rate at which the young planet is accreting is not steady.

Scientists create a paper-thin light that glows like the sun

Scientists have developed an ultra-thin, paper-like LED that emits a warm, sunlike glow, promising to revolutionize how we light up our homes, devices, and workplaces. By engineering a balance of red, yellow-green, and blue quantum dots, the researchers achieved light quality remarkably close to natural sunlight, improving color accuracy and reducing eye strain.

DNA repair mechanisms help explain why naked mole-rats live a long life

Naked mole-rats are one of nature’s most extraordinary creatures. These burrowing rodents can live for up to 37 years, around ten times longer than relatives of a similar size. But what is the secret to their extreme longevity? How are they able to delay the decay and decline that befalls other rodents? The answer, at least in part, is due to a switch in a common protein that boosts DNA repair, according to new research published in the journal Science.

One of the main causes of aging in all animals, including humans, is the accumulation of damaged DNA, our genetic instruction manual. When this damage is not fixed, it leads to , damaged proteins and eventually a breakdown in the body’s functions.

To understand how the naked mole-rat is so resistant to DNA damage, a study led by researchers at Tongji University in China focused on a common protein called cGAS (cyclic GMP-AMP synthase). In most mammals, cGAS interferes with DNA repair, but the researchers suspected it may have evolved a different function in the long-living rats.

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