In parallel, theorists have published an updated Standard Model prediction based purely on lattice QCD.
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‘Universal cancer vaccine’ trains the immune system to kill any tumor
Following on from their breakthrough human trial that successfully reprogrammed the immune system to overpower glioblastoma, an aggressive brain tumor, the same scientists have now further developed the mRNA vaccine to fight not one but any cancer. It has the potential to do away with chemotherapy, surgery and radiation treatment.
University of Florida (UF) scientists have developed an experimental vaccine that dramatically boosts the immune system’s ability to fight tumors – even without targeting a specific cancer type. This “general purpose” mRNA jab works in a similar way to a Covid-19 vaccine but with a different target; it instructs the body’s immune cells to rally and hit any kind of tumor in the same way they would attack a viral spike protein.
“This paper describes a very unexpected and exciting observation: that even a vaccine not specific to any particular tumor or virus – so long as it is an mRNA vaccine – could lead to tumor-specific effects,” said Elias Sayour, a pediatric oncologist and principal investigator at the RNA Engineering Laboratory at UF. “This finding is a proof of concept that these vaccines potentially could be commercialized as universal cancer vaccines to sensitize the immune system against a patient’s individual tumor.”
NVIDIA Brings Reasoning Models to Consumers Ranging from 1.5B to 32B Parameters
Today, NVIDIA unveiled OpenReasoning-Nemotron, a quartet of distilled reasoning models with 1.5B, 7B, 14B, and 32B parameters, all derived from the 671B-parameter DeepSeek R1 0528. By compressing that massive teacher into four leaner Qwen‑2.5-based students, NVIDIA is making advanced reasoning experiments accessible even on standard gaming rigs, without the need to worry about hefty GPU bills and cloud usage. The key is not some elaborate trick but raw data. Using the NeMo Skills pipeline, NVIDIA generated five million math, science, and code solutions, and then fine-tuned each one purely with supervised learning. Already, the 32B model hits an 89.2 on AIME24 and 73.8 on the HMMT February contest, while even the 1.5B variant manages a solid 55.5 and 31.5.
New optical microscope «sees» atoms — scientists bypass diffraction
An international team of researchers has developed a new visualization method ULA-SNOM, which allows optical microscopes to distinguish parts as small as 1 nanometer.
Gabe Newell thinks AI tools will result in a ‘funny situation’ where people who don’t know how to program become ‘more effective developers of value’ than those who’ve been at it for a decade
Even if you’re just a pure tool user you’re going to find that the gains to utilising those tools are very, very high.
Immune cells turn into ‘mini-Hulks’ to push away tissue and make space when migrating
Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies.
Research by the Sixt group at the Institute of Science and Technology Austria (ISTA) unveils how immune cells use their cytoskeleton to exert forces on their surrounding environment to push their way through tissues.
The findings were published in Nature Immunology.