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Single-molecule RNA mapping may reveal how shape shifts steer health and disease

Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method to study individual RNA molecules and reveal how their structures influence gene regulation, a fundamental process that affects how cells function in health and disease. Their work was published in Nature Methods.

RNA is best known for carrying genetic instructions from DNA to make proteins. However, RNA does more than act as a messenger. Like a string that can bend, fold and interact with other molecules, RNA can adopt different shapes that affect how it behaves in the cell. These shapes can influence how efficiently proteins are produced, how long RNA molecules last, and how diseases such as viral infections progress.

Until now, studying these structures in detail has been difficult because RNA is highly flexible and dynamic. Most existing methods only provide an average picture across many RNA molecules, making it harder to see how individual RNA molecules may fold differently, even when they come from the same gene.

Exploiting interfacial ionic mobility to make heat-moldable nanoparticle aggregates

If you have ever warped a cheap plastic cup by pouring coffee into it, then you have witnessed thermoplasticity in action. Thermoplasticity is the ability of a material to become pliable under heating. In industry, thermoplasticity is exploited to form materials into complex shapes using heat. However, some materials, such as aggregates of nanoparticles, are not thermoplastic and cannot be easily processed without affecting their particle morphology and properties.

However, researchers at The University of Osaka have been able to use heat to shape nanoparticle aggregates, specifically cellulose nanofibers (CNFs) derived from wood pulp. This exciting advance, showcasing the mechanical and thermal potential of nanoparticles, is published in Science Advances.

Ultra-thin membrane enables high-efficiency hydrogen fuel cells for transport and industry

Engineers have developed a new ultra-thin membrane that allows fuel cells to operate more efficiently at high temperatures by enabling proton transport without water, overcoming a key limitation in clean energy technologies.

The breakthrough, reported in Science Advances, could expand the use of fuel cells in transport, heavy industry, and future clean energy systems.

Fuel cells convert chemical energy directly into electricity, producing water and heat as the main by-products. They are already used in hydrogen-powered vehicles, backup power systems for hospitals and data centers, and space missions where lightweight, reliable energy is essential.

Seeing the invisible: The limits of two-photon vision

Near-infrared light is invisible to humans. And yet, under the right conditions, the human eye can perceive it. Researchers from Poland’s International Center for Translational Eye Research (ICTER) have now shown that the efficiency of this phenomenon depends not only on the laser pulse itself, but also on two highly specific factors: the beam diameter and the precise focusing of light on the retina. The research is published in the journal Optics Letters.

In everyday life, we see visible light—wavelengths detected by the photoreceptors of the retina. Near-infrared light lies outside this range, which is why it normally remains invisible to us. However, for several years, scientists have known of an exception.

This exception is known as two-photon vision. In this phenomenon, a photopigment in the retina absorbs two infrared photons almost simultaneously. Each photon individually carries too little energy to trigger visual perception, but together they can initiate the process of vision. This is why, under certain conditions, humans can “see” radiation that theoretically should remain invisible.

Sunlight-powered generation of correlated photon pairs

Pairs of correlated or entangled photons are a foundational resource in quantum optics. They are most commonly produced through spontaneous parametric down-conversion (SPDC), a nonlinear optical process that typically relies on a stable, coherent laser to pump a nonlinear crystal. Because of this requirement, SPDC has long been viewed as impractical without laboratory-grade laser systems.

Recent studies have shown that fully coherent light is not strictly necessary: Partially coherent sources can also drive SPDC, with their coherence properties transferred to the generated photon pairs. This insight raises a natural and intriguing question—can sunlight, the most abundant natural light source, be used to generate correlated photon pairs?

Using sunlight for SPDC presents clear challenges. Sunlight collected from the ground is inherently unstable, with continuous changes in intensity, angle, and position that interfere with the precise illumination and photon detection required for SPDC experiments. At the same time, sunlight offers a compelling advantage: it removes dependence on lasers and external power sources, opening possibilities for photon-pair generation in remote or extreme environments.

Microsoft Exchange, Windows 11 hacked on second day of Pwn2Own

During the second day of Pwn2Own Berlin 2026, competitors collected $385,750 in cash awards after exploiting 15 unique zero-day vulnerabilities in multiple products, including Windows 11, Microsoft Exchange, and Red Hat Enterprise Linux for Workstations.

The Pwn2Own Berlin 2026 hacking competition takes place at the OffensiveCon conference from May 14 to May 16 and focuses on enterprise technologies and artificial intelligence.

Security researchers can earn over $1,000,000 in cash and prizes by hacking fully patched products in the web browser, enterprise applications, cloud-native/container environments, virtualization, local privilege escalation, servers, local inference, and LLM categories.

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