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Professor Kenji Osafune (Department of Cell Growth and Differentiation) and his team of researchers have devised an effective means to grow iPS cell-derived kidney progenitor cells, paving the way for renal regenerative therapies to become a reality. The findings are published in the journal Science Translational Medicine.

Modern medicine continues to be hampered by the lack of effective treatments for (AKI) and (CKD). Regenerative medicine, such as cell replacement therapies, represents a new hope for patients. Yet, such therapeutic approaches require large-scale production of the necessary cells, which had remained a challenge until this discovery.

Using a mouse model of AKI, the research team first demonstrated the therapeutic potential of human iPS cell-derived nephron progenitor cells (hiPSC-NPCs). When these cells were transplanted into the kidneys of AKI mouse models induced by an anti-cancer drug, cisplatin, the animals’ survival was vastly improved by preventing the deterioration of kidney function.

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The frequency regime lying in the shortwave infrared (SWIR) has very unique properties that make it ideal for several applications, such as being less affected by atmospheric scattering as well as being “eye-safe.” These include Light Detection and Ranging (LIDAR), a method for determining ranges and distances using lasers, space localization and mapping, adverse weather imaging for surveillance and automotive safety, environmental monitoring, and many others.

However, SWIR light is currently confined to niche areas, like scientific instrumentation and military use, mainly because SWIR photodetectors rely on expensive and difficult-to-manufacture materials. In the past few years, —solution-processed semiconducting nanocrystals—have emerged as an alternative for mainstream consumer electronics.

While toxic heavy-metals (like lead or mercury) have typically been used, quantum dots can also be made with environmentally friendly materials such as silver telluride (Ag2Te). In fact, silver telluride colloidal quantum dots show device performance comparable to their toxic counterparts. But they are still in their infancy, and several challenges must be addressed before they can be used in practical applications.

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A team of Penn State researchers has used a new 3D-printing method to produce a complex metal build that was once only possible with welding: fusing two metals together into a single structure.

Using an advanced additive manufacturing process known as multi-material laser powder bed fusion—enabled by a newly acquired system in Penn State’s Center for Innovative Materials Processing Through Direct Digital Deposition (CIMP-3D)—the researchers printed a out of a blend of low-carbon stainless steel and bronze, which consists of 90% copper and 10% tin.

The researchers have published their approach in npj Advanced Manufacturing.

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To understand complex objects, humans are known to mentally transform them and represent them as a combination of simpler elements. This ability, known as compositionality, was so far assumed to require fluency in language, thus emerging in childhood after humans have learned to speak and understand others.

Researchers at Aix-Marseille University-CNRS and PSL University École des Hautes Études en Sciences Sociales-CNRS recently explored the possibility that compositionality is based on simple processes and might therefore already be present in infants. Their paper, published in Communications Psychology, provides evidence that infants as young as 1-year-old already possess basic compositional abilities.

“We are generally interested in understanding what is in place before language takes off in an infant’s mind,” Isabelle Dautriche, first author of the paper, told Medical Xpress. “One of the central properties of language is compositionality, which is a long word that simply means the capacity to put words together to understand sentences.

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The CMS collaboration at CERN has observed an unexpected feature in data produced by the Large Hadron Collider (LHC), which could point to the existence of the smallest composite particle yet observed. The result, reported at the Rencontres de Moriond conference in the Italian Alps this week, suggest that top quarks—the heaviest and shortest lived of all the elementary particles—can momentarily pair up with their antimatter counterparts to produce an object called toponium.

Other explanations cannot be ruled out, however, as the existence of toponium was thought too difficult to verify at the LHC, and the result will need to be further scrutinized by CMS’s sister experiment, ATLAS.

High-energy collisions between protons at the LHC routinely produce top quark–antiquark pairs (tt-bar). Measuring the probability, or cross section, of tt-bar production is both an important test of the Standard Model of particle physics and a powerful way to search for the existence of new particles that are not described by the 50-year-old theory. Many of the open questions in particle physics, such as the nature of dark matter, motivate the search for new particles that may be too heavy to have been produced in experiments so far.

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The gene encoding an enzyme from a firefly, discovered at the Sorocaba campus of the Federal University of São Carlos (UFSCar) in Brazil, has given rise to a biosensor capable of detecting pH changes in mammalian cells—which could be useful, for example, in studying diseases and assessing the toxicity of a drug candidate.

The luciferase from the species Amydetes vivianii changes color from bluish-green to yellow and red as acidity decreases in fibroblasts, the most common cell type in connective tissue. It does so with great intensity and stability, something that had not been achieved with other luciferases tested by the research group.

The work is published in the journal Biosensors.

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A team of physicists have discovered a new approach that redefines the conception of a black hole by mapping out their detailed structure, as shown in a research study recently published in Journal of High Energy Physics.

The study details new theoretical structures called “supermazes” that offer a more universal picture of to the field of theoretical physics. Based in , supermazes are pivotal to understanding the structure of black holes on a microscopic level.

“General relativity is a powerful theory for describing the large-scale structure of black holes, but it is a very, very blunt instrument for describing black-hole microstructure,” said Nicholas Warner, co-author of the study and professor of physics, astronomy and mathematics at the USC Dornsife College of Letters, Arts and Sciences. In a framework of theories extending beyond Einstein’s equations, supermazes provide a detailed portrait of the microscopic structure of brane black holes.

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