Blog – Page 2

From village dogs to toy poodles to mastiffs, dogs come in an astonishing array of shapes, colors and sizes. Today there are estimated to be about 700 million dogs living with or around humans.

To many of us, dogs are loyal companions, working partners, and beloved family members—and the histories of our species are deeply woven together. But how did this incredible diversity come to be—and how far back does this relationship with humans go?

Two new studies published today in Science provide some answers. One, led by Allowen Evin from the University of Montpelier, draws on ancient skeletal remains. The other, led by Shao-Jie Zhang from the Kunming Institute of Zoology, draws on the study of DNA from ancient Eastern Eurasian dogs.

Antibody-drug conjugates (ADCs) reflect a new promising approach in prostate cancer, even more so after the practice-changing results in other malignancies, either hematologic or solid. ADCs consist of monoclonal antibodies (mAb) targeted at specific antigens overly expressed on cancer cells compared to normal cells. A cytotoxic payload is attached to the mAb using a stable linker. In prostate cancer, PSMA, STEAP1, TROP2, CD46 and B7-H3 are antigens currently being studied as targets for ADCs. In this paper, we discuss the composition of ADCs and focus on their application and challenges as treatment options in prostate cancer.

Keywords: Antibody-drug conjugate; Monoclonal antibody; PSMA; Precision oncology; Prostate cancer.

Copyright © 2022 Elsevier Ltd. All rights reserved.

Cancer therapy targeting acetylation and autophagy.

💡 Liu, Y., Yan, Z., Fu, Z. et al. Cell Death Discov. 11, 522 (2025).

💡 Liu, Y., Yan, Z., Fu, Z. et al. Crosstalk between acetylation modification and autophagy in cancer: roles: mechanisms and therapeutic potential. Acta Pharmacol Sin. 2024;46:816–28.

One of the world’s most common viral infections could underlie virtually every case of lupus, according to a recent study providing the strongest evidence yet for a link.

The research, led by scientists at Stanford University, has found that the Epstein-Barr virus (EBV) could be the trigger behind the ‘cruel mystery’

EBV is the pathogen that causes ‘kissing disease’ (or mononucleosis), and according to the new findings, it can directly infect and reprogram specific immune cells, potentially driving the onset of the chronic autoimmune disease systemic lupus erythematosus – better known as simply lupus.