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Nasal anti-CD3 therapy shows promise for treating traumatic brain injury by reducing neuroinflammation and aiding recovery in mice. It induces interleukin-10-producing regulatory T cells that enhance microglial phagocytic activity and reduce chronic inflammation, potentially aiding brain repair.

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Humanity came close to extinction 800,000 years ago. Only 1,280 of our ancestors survived.

A recent study published in Science suggests that a catastrophic “ancestral bottleneck” reduced the global population to just 1,280 breeding individuals, wiping out 98.7% of the early human lineage.

This population crash, lasting about 117,000 years, likely resulted from extreme climate shifts, prolonged droughts, and dwindling food sources.

Using a groundbreaking genetic analysis method called FitCoal, researchers analyzed modern human genomes to trace this dramatic decline, potentially explaining a gap in the African and Eurasian fossil record.

Despite the near-extinction, this bottleneck may have played a crucial role in shaping modern humans. Scientists believe it contributed to a key evolutionary event—chromosome fusion—which may have set Homo sapiens apart from earlier hominin species, including Neanderthals and Denisovans. The study raises intriguing questions about how this small population survived, possibly through early fire use and adaptive intelligence. Understanding this ancient crisis helps scientists piece together the story of human evolution and the resilience that allowed our species to thrive against all odds.

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NASA has confirmed that Sunita Williams and Barry Wilmore will return to Earth in late March 2025 after spending over nine months aboard the ISS. Their return is scheduled to take place once the Crew-10 mission successfully arrives at the space station. Crew-10, carrying four new astronauts, will launch on March 12, 2025, at 7:48 PM EDT and undergo a week-long handover process before Williams and Wilmore begin their journey back. The decision to return them aboard a SpaceX Crew Dragon capsule was made due to ongoing technical issues with Boeing’s Starliner. NASA has assured that all necessary preparations are in place to facilitate a safe return. Sunita Williams Health Update: NASA Astronaut’s Mother Bonnie Pandya Dismisses Health Concerns Surrounding Her Daughter, Says ‘Space Is As Safe as Anywhere Else’ (Watch Video).

Williams and Wilmore’s return capsule, the SpaceX Crew Dragon, will follow a carefully planned re-entry trajectory before making a splashdown in designated waters. NASA has shortlisted landing sites in the Atlantic Ocean and the Gulf of Mexico, with the final decision depending on weather and oceanic conditions at the time of descent. SpaceX recovery teams will be stationed near the landing zone, ready to retrieve the capsule and transport the astronauts back to shore. After landing, Williams and Wilmore will undergo a thorough medical assessment before heading to NASA’s facilities for debriefing.

Sunita Williams’ return to Earth marks the end of an unexpectedly extended mission that was originally planned for just ten days but stretched to over nine months. The delay was primarily due to technical issues with Boeing’s Starliner, which faced multiple failures, including propulsion system malfunctions and propellant leaks. NASA, prioritising astronaut safety, decided to postpone their return until a reliable alternative was arranged.

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