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Advanced software uncovers elusive protein variants tied to genetic mutations

Scientists at UCLA and the University of Toronto have developed an advanced computational tool, called moPepGen, that helps identify previously invisible genetic mutations in proteins, unlocking new possibilities in cancer research and beyond.

The tool, described in Nature Biotechnology, will help understand how changes in our DNA affect proteins and ultimately contribute to cancer, neurodegenerative diseases, and other conditions. It provides a new way to create and to find treatment targets previously invisible to researchers.

Proteogenomics combines the study of genomics and proteomics to provide a comprehensive molecular profile of diseases. However, a major challenge has been the inability to accurately detect variant peptides, limiting the ability to identify at the protein level. Existing proteomic tools often fail to capture the full diversity of protein variations.

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New Material Breaks the Rules: Scientists Turn Insulator Into a Semiconductor

Once considered merely insulating, a change in the angle between silicon and oxygen atoms opens a pathway for electrical charge to flow.

A breakthrough discovery from the University of Michigan has revealed that a new form of silicone can act as a semiconductor. This finding challenges the long-held belief that silicones are only insulating materials.

“The material opens up the opportunity for new types of flat panel displays, flexible photovoltaics, wearable sensors or even clothing that can display different patterns or images,” said Richard Laine, U-M professor of materials science and engineering and macromolecular science and engineering and corresponding author of the study recently published in Macromolecular Rapid Communications.

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Scientists Identify Hidden Rule That Shapes All Life on Earth

Scientists found that species cluster in core bioregions and spread outward, likely due to environmental filtering, a pattern that could inform conservation and climate planning. A new study in Nature Ecology & Evolution has identified a simple rule that appears to shape how life is organized

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Scientists Detect Unusual Airborne Toxin in the United States for the First Time

University of Colorado Boulder researchers made the first-ever airborne detection of Medium Chain Chlorinated Paraffins (MCCPs) in the Western Hemisphere. Sometimes, scientific research feels a lot like solving a mystery. Scientists head into the field with a clear goal and a solid hypothesis, bu

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Light Squeezed Out of Darkness in Surprising Quantum Simulation

A careful alignment of three powerful lasers could generate a mysterious fourth beam of light that is throttled out of the very darkness itself.

What sounds like occult forces at work has been confirmed by a simulation of the kinds of quantum effects we might expect to emerge from a vacuum when ultra-high electromagnetic fields meet.

A team of researchers from the University of Oxford in the UK and the University of Lisbon in Portugal used a semi-classical equation solver to simulate quantum phenomena in real time and in three dimensions, testing predictions on what ought to occur when incredibly intense laser pulses combine in empty space.

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Microsoft shares temp fix for Outlook crashes when opening emails

Microsoft has shared a workaround for a known issue that causes the classic Outlook email client to crash when opening or starting a new message.

These problems affect users in the Monthly Enterprise Channel who updated Outlook for Microsoft 365 earlier this month, starting with Version 2,504 (Build 18730.20122).

“When you open or start a new email, classic Outlook crashes. This issue occurs because Outlook cannot open the Forms Library,” the Outlook team says in a support document published on Friday.

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Zoomcar discloses security breach impacting 8.4 million users

Zoomcar Holdings (Zoomcar) has disclosed that unauthorized accessed its system led to a data breach impacting 8.4 million users.

The incident was detected on June 9, after a threat actor emailed company employees alerting them of a cyberattack.

Although there has been no material disruption to services, the company’s internal investigation confirmed that sensitive data belonging to a subset of its customers has been compromised.

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Police seizes Archetyp Market drug marketplace, arrests admin

Law enforcement authorities from six countries took down the Archetyp Market, an infamous darknet drug marketplace that has been operating since May 2020.

Archetyp Market sellers provided the market’s customers with access to high volumes of drugs, including cocaine, amphetamines, heroin, cannabis, MDMA, and synthetic opioids like fentanyl through more than 3,200 registered vendors and over 17,000 listings.

Over its five years of activity, the marketplace amassed over 612,000 users with a total transaction volume of over €250 million (approximately $289 million) in Monero cryptocurrency transactions.

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