Crispr used in mice to reverse vision loss đ.
Qin and colleagues develop a genome-editing tool characterized by the versatility of prime editors and unconstrained PAM requirement of SpRY. In vivo gene corre.
Year 2020 Immortality in eyes achieved with Nad plus đđđ.
Glaucoma and age-related macular degeneration are leading causes of irreversible blindness worldwide with significant health and societal burdens. To date, no clinical cures are available and treatments target only the manageable symptoms and risk factors (but do not remediate the underlying pathology of the disease). Both diseases are neurodegenerative in their pathology of the retina and as such many of the events that trigger cell dysfunction, degeneration, and eventual loss are due to mitochondrial dysfunction, inflammation, and oxidative stress. Here, we critically review how a decreased bioavailability of nicotinamide adenine dinucleotide (NAD; a crucial metabolite in healthy and disease states) may underpin many of these aberrant mechanisms. We propose how exogenous sources of NAD may become a therapeutic standard for the treatment of these conditions.
Recovery teams participate in field rehearsals in preparation for the retrieval of the sample return capsule from NASAâs OSIRIS-REx mission at the Department of Defenseâs Utah Test and Training Range. The sample was collected from the asteroid Bennu in October 2020 by NASAâs OSIRIS-REx spacecraft and will return to Earth on September 24th, landing under parachute at the Utah Test and Training Range. Credit: NASA/Keegan Barber.
The OSIRIS-REx team also thought a lot about conditions on the ground itself. Late summer is monsoon season in the desert, so heavy rains could saturate the silty ground. Wet-cement-like mud would make driving difficult if off-road vehicles are required to help helicopters find and transport the capsule.
âWe should know by the end of monsoon season how much precipitation weâve received and the condition of the salt flats,â said Eric Nelson, a U.S. Army meteorologist supporting the mission. âA good indicator is Bonneville Speed Week, an annual racing event in August.â Since it went off without a hitch, âweâre probably okay.â
Looking to the past has made a more sustainable future possible in the shipping industry, with the latest wind-powered vessel taking to the seas for its first voyage.
The Pyxis Ocean from the Mitsubishi Corporation has been retrofitted with two âWindWingsâ sails â developed by BAR Technologies and produced by Yara Marine â on the cargo shipâs deck.
Measuring up to 123 feet (37.5 meters) high, the sails have been estimated to allow for up to 30% fuel savings on newly built ships while cutting carbon pollution.
What Is Artificial Intelligence?
Posted in futurism, robotics/AI
Artificial intelligence (AI) refers to complex software that performs tasks in a way similar to human brains, often by sensing and responding to a feature of their environment. This could mean learning to solve problems in unexpected ways, recognising the nuances of speech, or exhibiting some form of human-like creativity.
Just as no single quality defines human thinking, no clear line differentiates more basic computer programs from AI. It can be thought of more as an ideal than a category â using our own penchant for learning and problem solving to inspire new technology and answers to some of our biggest and most complex questions.
There are many different fields of AI, including âroboticsâ, but one of the most commonly known forms is referred to as âmachine learningâ. This involves a program applying known information to new experiences and âlearningâ how to take this historical information and its experiences into account in future actions.
At a somewhat small and unassuming airport in Maribor, Slovenia, German hydrogen propulsion startup H2FLY has quietly been building up to a major milestone in zero-emission aviation over the summer. And all the hard work has come to fruition, with the successful completion of the worldâs first crewed liquid hydrogen-powered flights.
Before any aviation history enthusiast out there goes âbut what about the Tupolev Tu-155?â â yes, the Soviets did try out liquid hydrogen as fuel 35 years ago, but only for one of the three engines. In contrast, H2FLYâs HY4 has now operated using only liquid hydrogen (as opposed to the gaseous kind) as fuel, relying solely on the hydrogen fuel-cell powertrain for the entire flight.
At a glance, Geminiâs ability to generate text and images gives it a serious advantage over GPT4 with respect to the range of content that it can produce.
However, perhaps the most threatening differentiator between the two is Googleâs vast array of proprietary training data. Google Gemini can process data taken across services, including Google Search, YouTube, Google Books, and Google Scholar.
The use of this proprietary data in training the Gemini models could result in a distinct edge in the sophistication of the insights and inferences that it can take from a data set. This is particularly true if early reports that Gemini is trained on twice as many tokens as GPT4 are correct.
The launch of ChatGPT last November shook Google to its foundations. The popular chatbot posed such a threat to the companyâs business that it had to declare a code red and began investing in catching up on the generative AI bandwagon. This effort has not only resulted in the release of Google Bard but also Gemini.
If you would like to harness the power of artificial intelligence to aid you in the creation of your next song or music video. You might be interested in a new video created by AI enthusiast Matt Wolfe. Artificial intelligence (AI) has emerged as a game-changer a wide variety of different sectors including AI art generation, writing and more. As well as offering innovative tools that can assist in creating songs and music videos.
This AI music writing overview guide provides an in-depth look into how some of these AI tools can be utilized to create a new songs and accompanying music videos, a process that is not only fascinating but also accessible to anyone with an interest in music and technology.
THE future has finally caught up as the worldâs first flying car has at last been unveiled nearly a year after the concept was announced.
Thanks to California-based Alef Aeronautics, a car that can fly is officially on the ground â and soon to be in the air.
Dubbed the Alef Model A, the technologically advanced concept car was revealed at the North America International Auto Show in Detroit, Michigan.
While it has long been known that ultraviolet (UV) light can help kill disease-causing pathogens, the COVID-19 pandemic has put a spotlight on how these technologies can rid environments of germs. However, the excimer lamps and LEDs that can directly emit light in the required deep-UV wavelengths generally have low efficiency or suffer from short lifetimes. Moreover, UV light of the wrong wavelength can actually be harmful to human cells.
Now, a team led by researchers from Osaka University has shown how an optical device made of aluminum nitride can be used to generate deep-UV light in a method wholly different from previous approaches. The team made use of a process called âsecond harmonic generation,â which relies on the fact that the frequency of a photon, or particle of light, is proportional to its energy. The study is published in the journal Applied Physics Express.
Most transparent materials are considered âlinearâ with respect to their response to light, i.e., photons cannot interact with each other. However, inside certain ânonlinearâ materials, two photons can be combined into a single photon with twice the energy, and thus, twice the frequency.