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Prof. Wang Hui, together with Prof. Lin Wenchu and associate Prof. Qian Junchao from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences, have recently reported a near infrared (NIR)-II-responsive carbon-coated iron oxide nanocluster that was guided by magnetic resonance imaging and capable of combined photothermal and chemodynamic therapy (CDT), for synergistic cancer treatment.

The results were published in SCIENCE CHINA Materials.

As a promising treatment strategy, CDT has become a hot spot in cancer research due to its simple operation and low side effects. The basic principle of CDT is that the nanozymes activate the intracellular Fenton reaction, leading to the over-production of hydroxyl radicals, which are toxic to cancer cells. Magnetite nanocrystals are widely used as Fenton reagents due to their non-invasive imaging ability and good biocompatibility. However, the ferromagnetic behavior and easy oxidization of magnetite nanocrystals lead to colloidal instability as nanozymes and limit the imaging-guided cancer therapy in practical applications.

Physicists at the University of Wisconsin-Madison have directly measured the fluid-like flow of electrons in graphene at nanometer resolution for the first time. The results appear in the journal Science today.

Graphene, an atom-thick sheet of carbon arranged in a honeycomb pattern, is an especially pure electrical conductor, making it an ideal material to study electron flow with very low resistance. Here, researchers intentionally add impurities at known distances, and find that electron flow changes from gas-like to fluid-like as the temperature rises.

“All conductive materials contain impurities and imperfections that block electron flow, which causes resistance. Historically, people have taken a low-resolution approach to identifying where resistance comes from,” says Zach Krebs, a physics graduate student at UW-Madison and co-lead author of the study. “In this study, we image how charge flows around an impurity and actually see how that impurity blocks current and causes resistance, which is something that hasn’t been done before to distinguish gas-like and fluid-like electron flow.”

Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes seem to hold a potent biological function that’s potentially relevant to our understanding of cancer and aging.

Reporting in the Proceedings of the National Academy of Sciences, UNC School of Medicine researchers Taghreed Al-Turki, Ph.D., and Jack Griffith, Ph.D., made the stunning discovery that telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells, as well as cells from patients suffering from telomere-related defects.

“Based on our research, we think simple blood tests for these proteins could provide a valuable screen for certain cancers and other human diseases,” said Griffith, the Kenan Distinguished Professor of Microbiology and Immunology and member of the UNC Lineberger Comprehensive Cancer Center. “These tests also could provide a measure of ‘telomere health,’ because we know telomeres shorten with age.”

In a paper published in the journal National Science Open, the morphology and structure regulation methods of supramolecular assembly are summarized. Then, recent progresses of supramolecular assembly derived carbon-nitrogen-based materials for photo/electrocatalysis are discussed. Furthermore, the developments and challenges in future are prospected.

The sustainable energy storage and conversion technologies based on redox reactions are promising pathway to solve energy issues. However, there is still lack of low-cost, ecofriendly and highly active photo/electrocatalysts, which play a crucial role in the redox reactions.

In this review, the author first summarized the effects of temperature, solvent type, pH value and monomer on the morphology and structure of the supramolecular assembly. Then, the effects of morphology and structure regulation on the physicochemical properties of supramolecular assembly-derived carbon-nitrogen-based materials were discussed, which determined the essential properties of catalysts for a specific photo/electrocatalytic reaction.

Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1 (HIV-1), the knowledge of immunological and virological correlates of cure is limited. Here we characterize a case of long-term HIV-1 remission of a 53-year-old male who was carefully monitored for more than 9 years after allogeneic CCR5Δ32/Δ32 HSCT performed for acute myeloid leukemia. Despite sporadic traces of HIV-1 DNA detected by droplet digital PCR and in situ hybridization assays in peripheral T cell subsets and tissue-derived samples, repeated ex vivo quantitative and in vivo outgrowth assays in humanized mice did not reveal replication-competent virus.

Nature Publication:

After the Berlin Patient, and the London Patient. There appears to be a third patient cured of HIV through stem cell transplantation.

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Materials scientists are often inspired by nature and therefore use biological compounds as cues to design advanced materials. It is possible to mimic the molecular structure and functional motifs in artificial materials to offer a blueprint for a variety of functions. In a new report in Science Advances, Tae Hyun Kim and a research team at the California Institute of Technology and the Samsung Advanced Institute of Technology in the U.S. and South Korea, created a flexible biomimetic thermal sensing polymer, abbreviated BTS, which they designed to mimic ion transport dynamics of pectin; a plant cell wall component.

The researchers used a versatile synthetic procedure and engineered the properties of the polymer to be elastic, flexible and stretchable in nature. The flexible polymer outperformed state-of-the-art temperature sensing materials such as vanadium oxide. Despite mechanical deformations, the thermal sensor-integrated material showed high sensitivity and stable functionality between 15° and 55° Celsius. The properties of the flexible BTS polymer made it well suited to map temperature variations across space-time and facilitate broadband infrared photodetection relevant for a variety of applications.

Organic electronic materials are competitive alternatives to conventional silicon-based microelectronics due to their cost-effective, multifunctional nature. Materials scientists seek to tailor the properties of such materials at the molecular level for a range of sensing applications for wearable and implantable devices with specific characteristics such as flexibility and elasticity. At present, there is an increasing demand for all-organic electronic devices to form a range of soft and active materials. For instance, organic thermal sensors are suited for remote health care and robotics, albeit with limitations.

https://youtube.com/watch?v=4LevUzfdBtw

In this video, I’ll discuss some of the most advanced humanoid robots currently in development and reveal if the future really is bright for Robotics.

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Some images to help orient you in the midst of Whitehead’s categoreal forest.

I explore the reduction of thermodynamics to statistical mechanics by treating the former as a control theory: a theory of which transitions between states can be induced on a system (assumed to obey some known underlying dynamics) by means of operations from a fixed list. I recover the results of standard thermodynamics in this framework on the assumption that the available operations do not include measurements which affect subsequent choices of operations. I then relax this assumption and use the framework to consider the vexed questions of Maxwell’s demon and Landauer’s principle. Throughout I assume rather than prove the basic irreversibility features of statistical mechanics, taking care to distinguish them from the conceptually distinct assumptions of thermodynamics proper.

Annual UWO Philosophy of Physics Conference.
Thermodynamics as a Resource Theory: Foundational and Philosophical Implications.
June 20–22, 2018
http://philphysics.uwo.ca.
David Wallace, University of Southern California.

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