Skin functions as a sophisticated sensorial system in the human body, capable not only of detecting environmental stimuli—such as temperature, pressure, strain, and vibration—but also of actively responding to these changes. Among these, the temperature regulation capability of the skin plays a critical role in maintaining the stability of homeothermic animals.
A new study has been led by Prof. Xing-Hua Xia (State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University). While analyzing the infrared photoinduced force response of quartz, Dr. Jian Li observed a unique spectral response that is different from the far field infrared absorption spectrum.
A team of chemists and bioengineers at Rice University and the University of Houston have achieved a significant milestone in their work to create a biomaterial that can be used to grow biological tissues outside the human body.
The results of a metagenomic study from the University of Trento suggest that the CRISPR toolbox will need to make room for another CRISPR enzyme. The disruption should be minimal because the newly identified enzyme is unusually compact. It consists of just over 1,000 amino acids. And yet it is also strongly active and highly precise. The hope is that it can be packaged with guide RNA within the tight quarters afforded by adeno-associated virus (AAV) vectors, and thereby expand the use of in vivo gene editing in therapeutic applications.
The study was led by Anna Cereseto, PhD, and Nicola Segata, PhD, of the department of cellular, computational, and integrative biology. Cereseto leads a laboratory that develops advanced genome editing technologies and their application in the medical sector. Segata is the head of a laboratory of metagenomics, where he studies the variety and characteristics of the human microbiome and its role in health. Their collaboration has led to the identification, in a bacterium of the intestine, of new CRISPR-Cas9 molecules that could have a clinical potential to treat genetic diseases.
Detailed findings from the study recently appeared in Nature Communications, in an article titled, “CoCas9 is a compact nuclease from the human microbiome for efficient and precise genome editing.”
Nature Biotechnology volume 42, pages 551–554 (2024) Cite this article.
Earth’s magnetic field plays a key role in making our planet habitable. The protective bubble over the atmosphere shields the planet from solar radiation, winds, cosmic rays and wild swings in temperature.
However, Earth’s magnetic field almost collapsed 591 million years ago, and this change, paradoxically, may have played a pivotal role in the blossoming of complex life, new research has found.
“In general, the field is protective. If we had not had a field early in Earth history water would have been stripped from the planet by the solar wind (a stream of energized particles flowing from the sun toward Earth),” said John Tarduno, a professor of geophysics at the University of Rochester in New York and senior author of the new study.