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Ceramic nanowires could essentially be used even for car tires reducing even hazardous rubber waste.

A team of MIT-led engineers found a simple, inexpensive way to strengthen Inconel 718 with ceramic nanowires to be used in metal PBF AM processes. The team believes that their general approach could be used to improve many other materials. “There is always a significant need for the development of more capable materials for extreme environments. We believe that this method has great potential for other materials in the future,” said Ju Li, the Battelle Energy Alliance Professor in Nuclear Engineering and a professor in MIT’s Department of Materials Science and Engineering (DMSE).

Li, who is also affiliated with the Materials Research Laboratory (MRL), is one of three corresponding authors of a paper on the work that appeared in the April 5 issue of Additive Manufacturing. The other corresponding authors are Professor Wen Chen of the University of Massachusetts at Amherst and Professor A. John Hart of the MIT Department of Mechanical Engineering.

Co-first authors of the paper are Emre Tekoğlu, an MIT postdoc in the Department of Nuclear Science and Engineering (NSE); Alexander D. O’Brien, an NSE graduate student; and Jian Liu of UMass Amherst. Additional authors are Baoming Wang, an MIT postdoc in DMSE; Sina Kavak of Istanbul Technical University; Yong Zhang, a research specialist at the MRL; So Yeon Kim, a DMSE graduate student; Shitong Wang, an NSE graduate student; and Duygu Agaogullari of Istanbul Technical University. The study was supported by Eni S.p. A. through the MIT Energy Initiative, the National Science Foundation, and ARPA-E.

Continue reading “MIT researchers develop Inconel 718-ceramic nanowires powder for AM” | >

Thanks to directed evolution accelerating natural selection processes, scientists are generating mutants with beneficial properties and improving functionality.

Learn more about these reagents in the new Research Products.

Directed evolution approaches are creating new reagents to help a tried-and-true technique reach new heights.

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Patients with advanced/metastatic non–human epidermal growth factor receptor 2 (HER2)-positive gastric/gastroesophageal junction cancer (GC/GEJC) or esophageal adenocarcinoma (EAC) and treated with Opdivo (nivolumab) and chemotherapy maintained their health-related quality of life (HRQoL) “with a reduced risk of definitive deterioration in disease-related and overall health status and without increased treatment-related symptom burden” when compared with patients treated with standalone chemotherapy, according to recent study findings.

Those findings, published in the Journal of Clinical Oncology, “can be helpful when counseling patients with advanced or metastatic GE/GEJC or EAC, providing reassurance that the benefits of adding (Opdivo) to chemotherapy extend not only to improved survival, but also to preservation of their quality of life and prolonged symptom control,” wrote Journal of Clinical Oncology associate editor, Dr. Andrew H. Ko, in a contextual commentary published alongside the study.

Analyzing patient-reported outcomes (PROs) from the phase 3 CheckMate 649 trial, researchers assessed 1,581 participants’ HRQoL via the EQ-5D and Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) scales, including the FACT-General (FACT-G) and Gastric Cancer subscale (GaCS), with the FACT-G GP5 item used to assess treatment-related symptom burden, and studied longitudinal changes in HRQoL measured with mixed models for repeated measures in the PRO analysis population of 1,360 randomly assigned patients, researchers detailed, noting that they also conducted time to symptom or definitive deterioration analyses.

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Some asteroids are dense. So dense in fact, that they may contain heavy elements outside of the periodic table, according to a new study on mass density.

The team of physicists from The University of Arizona say they were motivated by the possibility of Compact Ultradense Objects (CUDOs) with a mass density greater than Osmium, the densest naturally occurring, stable element, with its 76 protons.

“In particular, some observed asteroids surpass this mass density threshold. Especially noteworthy is the asteroid 33 Polyhymnia,” the team writes in their study, adding that “since the mass density of asteroid 33 Polyhymnia is far greater than the maximum mass density of familiar atomic matter, it can be classified as a CUDO with an unknown composition.”

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When it comes to human longevity, you might envision nanobots helping our bodies operate more efficiently. But our bodies are biological machines in their own right, evolved to handle any situation in the real world from illness to cold to hunger. Our bodies heal themselves, and they can be programmed to do so if we understood that language better.

This video talks about DNA and genes, and the epigenetic mechanisms that read that information. The epigenetic clock is one way to measure the age of cells, and this can be reversed with current technologies. We discuss experiments by David Sinclair, which made blind mice see again, and experiments by Greg Fahy, which regenerated the immune system of humans and reset their cellular age by 2 years.

Asking our bodies to heal themselves could be one of the largest medical breakthroughs ever, instead of trying mainly chemical means of medication. And it has significant implications for whether or not we can achieve longevity escape velocity and continue to live more or less indefinitely. This promises to be a very interesting topic.

#aging #longevity #science.

Continue reading “Unlocking immortality: the science of reversing aging” | >

For the first time, scientists have managed to deflect lightning, to the relief of anyone afraid of thunder and lightning storms but probably the chagrin of Zeus. They managed to show that lasers can act as virtual lightning rods, redirecting the direction in which bolts jump.

The Franklin lightning rod was a major scientific advance of its day, preventing millions of fires and electrocutions and demonstrating humanity’s capacity to control forces we had long feared as belonging to the gods. Nevertheless, it’s been 270 years, and it remains the basis of our lightning protection: maybe it’s time for an upgrade.

That is what Dr Aurélien Houard of ENSTA Paris and co-authors propose in a paper pubpished in Nature Photonics, demonstrating that laser pulses can change the direction of a lightning strike.

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