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Eli Lilly & Novartis are entering a strategic research collaboration with Isomorphic Labs to use state-of-the-art AI technologies—including the next-gen model of #AlphaFold—to discover novel small molecule therapeutics for select biological targets.


We are reimagining the entire drug discovery process from first principles with an AI-first approach.

Dementia and stroke often have devastating consequences, so patients want to know what they can do to protect themselves against these diseases. A team of clinicians in partnership with patients developed a Brain Care Score (BCS) based on modifiable risk factors identified in past epidemiological studies. In the BCS, weights are assigned to four physical components (i.e., blood pressure, glycosylated hemoglobin, cholesterol, and body-mass index), to five lifestyle elements (i.e., nutrition, alcohol intake, smoking, aerobic activities, and sleep), and to three social factors (i.e., stress, relationships, and purpose in life). Lower scores on the BCS (range, 0–19) predict higher risk.

The team then validated whether the BCS predicted new dementia or stroke in the U.K. Biobank cohort, which consisted of 398,900 people (age range at baseline, 40–69). During average follow-up of nearly 13 years, new dementia or stroke occurred in ≈3% of the cohort. The BCS identified people who were at highest risk for these outcomes. For example, among those who were younger than 50 at baseline, a 5-point higher score predicted 59% lower risk for dementia and 48% lower risk for stroke.

This score could be computed automatically from information already in electronic health records and used to identify risk factors and to engage patients in modifying those risk factors. Whether such scoring would actually lead to lower incidences of dementia and stroke remains to be seen.

Generative AI is also expected to play a significant role in 6G mobile technology. This year, work to set and agree on 6G standards will continue with the anticipation that the first standards could be introduced between 2027 and 2028, and the technology could reach commercialisation by 2030. Generative AI can be applied to various aspects of 6G, such as network resource management, spectrum allocation and network topology optimisation.

It is also capable of meeting the demands of “connective intelligence” for new technologies. Connective intelligence is a key force driving the development of the 6G network, enabling real-time, reliable and ubiquitous interaction and communication between humans, the physical world and the digital world. This results in the creation of a decentralised and continually evolving intelligence, making it easier for users to share their discoveries and experiences with each other.

In summary, by the end of 2024, generative AI will become an invaluable assistant, providing support and help across different industries. Its powerful analysis and predictive capabilities will enable people to handle complex tasks and problems more efficiently, offering real-time solutions and recommendations.

Almost exactly one year ago at CES 2023, Qualcomm announced its Snapdragon Ride Flex system-on-chip (SoC) product family. As an expansion of the company’s Snapdragon Digital Chassis product portfolio, the new SoC family is meant to support advanced driver assistance systems (ADAS) as well as digital cockpit and infotainment applications spanning from entry level to premium vehicles. At the time, Qualcomm announced that the Ride Flex SoC was sampling with an expected start of production in early 2024. It’s now early 2024 and CES is about to kick off again. Tirias Research is expecting to hear an update on the product family next week. We anticipate the update will include, at the very least, some of the partners who will be bringing the Ride Flex SoCs to market in production volumes this year and into 2025. Given Qualcomm’s track record for hitting their estimated timelines, we felt that a re-cap of the product family is warranted leading up to next week’s anticipated update.

“Flex-ing” Resources to Support Mixed Criticality and Multiple Tiers

The Snapdragon Ride Flex is actually two monolithically integrated 4nm SoCs – a primary SoC and what Qualcomm are calling a Safety Island SoC. The primary SoC consists of a Kryo Gen 6 Arm v8.2 central processing unit (CPU) with integrated L3 cache, an Adreno 663 graphics processing unit (GPU), a Hexagon neural processing unit (NPU), a Spectra 690 image signal processing (ISP), two Adreno display processing units (DPUs) for multiple high-resolution display support and associated memory and I/O interconnects. This part of the SoC is Automotive Safety Integrity Level (ASIL) B certified. The Safety Island SoC, which is ASIL-D certified, consists of a multi-core real-time CPU with enhanced error managements support and isolated memory and peripherals. ASIL is a risk classification methodology established under ISO 26,262 from the International Organization for Standardization which defines functional safety for road vehicles.