Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 2,530

I don’t know what’s the matter with people: they don’t learn by understanding; they learn by some other way—by rote or something.

First-principles thinking is one of the best ways to reverse-engineer complicated problems and unleash creative possibility. Sometimes called “reasoning from first principles,” the idea is to break down complicated problems into basic elements and then reassemble them from the ground up. It’s one of the best ways to learn to think for yourself, unlock your creative potential, and move from linear to non-linear results.

This approach was used by the philosopher Aristotle and is used now by Elon Musk and Charlie Munger. It allows them to cut through the fog of shoddy reasoning and inadequate analogies to see opportunities that others miss.

A first principle is a foundational proposition or assumption that stands alone. We cannot deduce first principles from any other proposition or assumption.

Read more | >

Year 2021 face_with_colon_three

Creatine plays a pivotal role in cellular bioenergetics, acting as a temporal and spatial energy buffer in cells with high and fluctuating energy requirements (1). Jeopardizing delicate creatine homeostasis can be detrimental to many energy-demanding tissues, including the brain. For instance, cerebral creatine hypometabolism accompanies various neurological conditions, including a number of developmental disorders (2, 3), neurodegenerative and cerebrovascular diseases (4, 5), and brain cancer (6). A reduced creatine availability in the brain has been thus recognized as an apposite therapeutic target, and supplying exogenous creatine to compensate for a disease-driven shortfall emerged as a first possible approach. However, early success in animal models of neurological diseases was not corroborated in human trials, with the use of creatine supplementation proved largely disappointing in clinical studies with a number of symptomatic neurological disorders [for a detailed review, see (7)]. A meager delivery of creatine to the brain could be partly due to a low activity/density of creatine transporter (CT1 or SLC6A8), a transmembrane sodium-and chloride-dependent protein that mediates creatine uptake into the target cells (8). For that reason, the upregulation of CT1 function has been identified as an innovative course of action to facilitate creatine uptake, with several exotic agents and routes were cataloged so far, including glucocorticoid-regulated kinases, mammalian target of rapamycin, ammonia, and Klotho protein (9).

Besides other vehicles, Klotho protein (Clotho; HFTC3) is put forward as a possible stimulator of CT1 function that can uplift creatine allocation to the target tissues. This membrane-bound pleiotropic enzyme (also exists in a circulating form) participates in many metabolic pathways, including calcium-phosphate metabolism, nutrient sensing, and remyelination (10). Klotho is highly expressed in neuronal cells of the cerebral cortex, cerebellum, and spinal cord (11). The role of Klotho in high-phosphate energy metabolism modulation was revealed a few years ago when Amilaji et al. (12) found that the co-expression of Klotho protein increases a creatine-induced current in CT1-expressing cells. The authors reported that the current through CT1 was a function of the extracellular creatine levels, with the maximal creatine-induced current was higher in cells expressing CT1 together with Klotho than in cells expressing CT1 alone (29.5 vs. 20.2 nA).

Read more | >

In a major step towards returning humans to the Moon for the first time since 1972, the Mohammed bin Rashid Space Centre (MBRSC) of the United Arab Emirates (UAE) recently announced they will be providing the airlock for NASA’s Lunar Gateway, which is the planned space station that will be in orbit around the Moon and responsible for ferrying future astronauts to and from the lunar surface.

Artist’s rendition of the Lunar Gateway (left) and a potential future airlock provided by the UAE (right). (Credit: NASA)

“The United States and the United Arab Emirates are marking a historic moment in our nations’ collaboration in space, and the future of human space exploration,” said NASA Administrator Bill Nelson. “We are in a new era of exploration through Artemis – strengthened by the peaceful and international exploration of space. The UAE’s provision of the airlock to Gateway will allow astronauts to conduct groundbreaking science in deep space and prepare to one day send humanity to Mars.”

Read more | >

Popular smart lighting company Nanoleaf today announced the launch of several new Matter-enabled lighting options, including its first outdoor lights. The company is also debuting a new music feature and accepting pre-orders for the Nanoleaf Skylight.

Nanoleaf’s Matter-enabled lights include the Smart Multicolor Lightstrip, the Smart Multicolor Outdoor String Lights, and the Smart Multicolor Permanent Outdoor Lights. The Outdoor String Lights feature large bulbs for decorating a front entryway, patio, or deck, while the permanent lights are designed to be installed under the eaves of a house in lieu of holiday string lights.

Read more | >

Laboratory “copilots” and automated labs are AI’s latest contribution to speeding up the development of new drugs, chemicals and materials. Why it matters: Scientific discovery itself must speed up if the world is to address its challenges — from climate change to personalized treatments for cancer — fast enough to make a difference. In scientific research, “manual effort is not scalable,” writes Microsoft Health Futures’ Hoifung Poon in the…

Read more | >

Although chaos theory can solve nearly anything that is unknown I basically think that in an infinite universe as made real from the infinite microchip that uses superfluid processing power is the real answer and we are off by factor of infinite parameters still.

When we look at scientific progress, especially in physics, it can seem like all the great discoveries lie behind us. Since the revolutions of Einstein’s theory of relativity and quantum mechanics, physicists have been struggling to find a way to make them fit together with little to no success. Tim Palmer argues that the answer to this stalemate lies in chaos theory.

Revisiting a book by John Horgan, science communicator and theoretical physicist Sabine Hossenfelder recently asked on her YouTube channel whether we are facing the end of science. It might seem like a rhetorical question — it’s not possible for science to really end — but she concludes that we are in dire need of some new paradigms in physics, and seemingly unable to arrive at them. We are yet to solve the deep ongoing mysteries of the dark universe and still haven’t convincingly synthesised quantum and gravitational physics. She suggests that ideas from chaos theory might hold some of the answers, and therefore the ability to rejuvenate science. I think she’s right.

Many physicists – perhaps most — might think this is surely a silly idea. After all, chaotic systems are describable by elementary classical Newtonian dynamics. The phenomenon of chaos can be illustrated by taking the simplest of dynamical systems, the pendulum, and simply adding a second pivot into its swinging arm. The motion of the tip of the pendulum arm is hard to predict, being sensitive to its exact starting conditions – the hallmark of chaos. Fascinating yes, but surely, if we have learned anything over the last 100 years it is this: we are not going to make progress in fundamental physics by going back to elementary classical dynamics.

Read more | >

There was a flurry of activity towards the end of the year as large corporations look to establish local HQs. Other firms that have recently received such licenses are Airbus SE, Oracle Corp. and Pfizer Inc.

Saudi Arabia announced the new rules for state contracts in February 2021, saying it wanted to limit ‘economic leakage’ — a term used by the government for state spending that can benefit firms that don’t have a substantial presence in the country.

A key part of Crown Prince Mohammed bin Salman’s economic agenda has been to limit some of the billions in spending by the government and Saudi citizens that leave the country each year. Government officials want to stop giving contracts to international firms who only fly executives in and out of the kingdom.

Read more | >

The first functional semiconductor made from graphene has been created at the Georgia Institute of Technology. This could enable smaller and faster electronic devices and may have applications for quantum computing.

Credit: Georgia Institute of Technology.

Semiconductors, which are materials that conduct electricity under specific conditions, are foundational components of electronic devices like the chips in your computer, laptop, and smartphone. For many decades, their architecture has been getting smaller and more compact – a trend known as Moore’s Law. This has enabled gigantic leaps in a vast range of technologies, from general computing speeds and video game graphics, to the resolution of medical scans and the sensitivity of astronomical observatories.

Read more | >

As a result, the company is now racing to make the most of the situation, though a full Moon landing is now sounding more or less impossible.

“We are currently assessing what alternative mission profiles may be feasible at this time,” the company wrote.

It’s a sad state of affairs. In the most recent update, the company shared the first photo the lander snapped in space, showing a creased layer of insulation, which may have contributed to the spacecraft’s ongoing issues.

Read more | >