Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 24

An international study led by the Institut de Neurociències at the UAB (INc-UAB) has shown that increasing levels of the Klotho protein in mice extends lifespan and improves both physical and cognitive health when aging.

As we grow older, it is natural to lose and , leading to greater frailty and a higher risk of falls and serious injuries. Cognitively, neurons progressively degenerate and lose connections, while diseases such as Alzheimer’s and Parkinson’s become more prevalent. In a society where the population is steadily aging, reducing these effects is one of the main challenges for research.

Now, in an article published in Molecular Therapy, an international research team led by Professor Miguel Chillón, ICREA researcher at the INc-UAB, has shown that increasing levels of the secreted form of the Klotho protein (s-KL) improves aging in mice.

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Two recent studies published in Biological Conservation and Nature Reviews Earth & Environment, led by researchers from the Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB) and the Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, highlight the profound impacts of hydropower on biodiversity in river channels and at the land-water surface.

The studies demonstrate that these effects arise from impoundment upstream of the dams, disruptions to the natural flow, sediment, and thermal regimes in downstream channels and floodplains, altering habitat conditions and environmental cues vital for many species to complete their life cycles.

The authors provide an overview of measures aimed at mitigating these adverse effects. They underscore the importance of systematic planning, long-term monitoring, adaptive management, and decision-making involving multiple actors to ensure and call for a critical reassessment of hydropower’s status as an often claimed environmentally friendly energy source.

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IN A NUTSHELL 🌌 Astronomers discovered Eos, a massive molecular cloud just 300 light-years from Earth, using innovative detection methods. 🔍 Eos eluded previous detection due to its low carbon monoxide content, highlighting the need for new observational techniques. 🌠 The cloud’s crescent shape is influenced by interactions with the North Polar Spur, offering insights

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When RNA molecules are synthesized by cells—a critical process in the creation of proteins and other cellular functions—they typically undergo a series of “folding” events that determine their structure and the role they will play in expressing genetic information in living organisms.

Until recently, however, not much was known about these folding processes that occur very early in the life of RNA molecules.

But Yale researchers have now developed a method to map and measure the structure of RNA as it develops, an advance that may help scientists design more effective treatments for a host of diseases. Their findings are described in the journal Molecular Cell.

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The ideal material for interfacing electronics with living tissue is soft, stretchable, and just as water-loving as the tissue itself—in short, a hydrogel. Semiconductors, the key materials for bioelectronics such as pacemakers, biosensors, and drug delivery devices, on the other hand, are rigid, brittle, and water-hating, impossible to dissolve in the way hydrogels have traditionally been built.

A paper published today in Science from the UChicago Pritzker School of Molecular Engineering (PME) has solved this challenge that has long stymied researchers, reimagining the process of creating hydrogels to build a powerful semiconductor in form. Led by Asst. Prof. Sihong Wang’s research group, the result is a bluish gel that flutters like a sea jelly in water but retains the immense semiconductive ability needed to transmit information between living tissue and machine.

The material demonstrated tissue-level moduli as soft as 81 kPa, stretchability of 150% strain, and charge-carrier mobility up to 1.4 cm2 V-1 s-1. This means their material—both semiconductor and hydrogel at the same time—ticks all the boxes for an ideal bioelectronic interface.

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