Lifeboat Foundation

New steps have been taken towards a better understanding of the immediate and long-term impact of COVID-19 on the brain in the UK’s largest study to date.

Published in Nature Medicine, the study from researchers led by the University of Liverpool alongside King’s College London and the University of Cambridge as part of the COVID-CNS Consortium shows that 12–18 months after hospitalisation due to COVID-19, patients have worse cognitive function than matched control participants. Importantly, these findings correlate with reduced brain volume in key areas on MRI scans as well as evidence of abnormally high levels of brain injury proteins in the blood.

Strikingly, the post-COVID cognitive deficits seen in this study were equivalent to twenty years of normal ageing. It is important to emphasise that these were patients who had experienced COVID, requiring hospitalisation, and these results shouldn’t be too widely generalised to all people with lived experience of COVID. However, the scale of deficit in all the cognitive skills tested, and the links to brain injury in the brain scans and blood tests, provide the clearest evidence to date that COVID can have significant impacts on brain and mind health long after recovery from respiratory problems.

A powerful new analytical tool offers a closer look at how tumor cells “shape-shift” to become more aggressive and untreatable, as shown in a study from researchers at Weill Cornell Medicine and the New York Genome Center.

A tumor cell shape-shifts by changing its cell type or state, thus altering its basic pattern of activity and perhaps even its appearance. This changeability or “plasticity” is a characteristic of cancer that leads to diverse tumor-cell populations and ultimately the emergence of cell types enabling treatment resistance and metastatic spread.

The new tool, described Sept. 24 in a paper in Nature Genetics, can be used to quantify this plasticity in samples of tumor cells. The researchers demonstrated it with analyses of tumor samples from animal models and human patients, identifying, for example, a key transitional cell state in glioblastoma, the most common form of brain cancer.

The FDA has approved a new targeted drug specifically for brain tumors called low-grade gliomas. The drug, vorasidenib, was shown in clinical trials to delay progression of low-grade gliomas that had mutations in the IDH1 or IDH2 genes.

“Although there have been other targeted therapies for the treatment of brain tumors with the IDH mutation, [this one] has been one of the most successful in survival prolongation of brain tumor patients,” said Darell Bigner, MD, PhD, the E. L. and Lucille F. Jones Cancer Distinguished Research Professor and founding director of the Preston Robert Tisch Brain Tumor Center at Duke.

In clinical trials, progression-free survival was estimated to be 27.7 months for people in the vorasidenib group versus 11.1 months for those in the placebo group.

University of Maryland scientists uncovered evidence of an ancient seafloor that sank deep into Earth during the age of dinosaurs, challenging existing theories about Earth’s interior structure.

UMD geologists discover a mysterious subduction zone deep beneath the Pacific Ocean, reshaping our understanding.

Does nature have to do everything itself?

An international cohort of marine scientists discovered an ocean-borne fungus chomping through plastic trash suspended in the Great Pacific Garbage Patch, as detailed in a new study published in the journal Science of the Total Environment.

Dubbed Parengyodontium album, the fungus was discovered among the thin layers of other microbes that live in and around the floating plastic pile in the North Pacific.

Clearly customers are voicing their concerns about the ongoing Verizon outage. In fact, there has already been over 2,900 replies to Verizon’s post on X. Many of the responders still claim they are unable to make phone calls.

2024–09-30T17:22:33.585Z

O.o!!!

The strike is set to significantly disrupt trade, creating uncertainty ahead of the US election.

New device boosts hydroponic farming for efficient, eco-friendly food production:

A new water purification device offers a cost-effective solution for hydroponic farming, supporting more sustainable food production.

Continue reading “New water purifier could drive sustainable farming in changing climate” »

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