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Scientists have found that lemborexant not only increased restorative sleep in male mice but also reduced levels of toxic tau and brain inflammation. The findings suggest that targeting the brain’s orexin system may help slow Alzheimer’s progression.

Chimeric antigen receptor (CAR)-T cells are a promising cancer therapy that are made from the patient’s own T cells, which are reprogrammed to fight their cancer. One of the limitations of CAR-T cell therapy is the ability of these cells to survive long enough to target the entire tumor.

Once injected back into the patient, the CAR-T cells tend to rapidly expand when they become activated by the , but eventually die off due to a natural process called activation-induced cell death.

In a study published in Science Translational Medicine, a research team discovered a way to alter CAR-T cells so they can partially avoid activation-induced cell death, which allows them to live longer and better fight off the tumor.