Lifeboat Foundation

Regorafenib.

For patients with metastatic esophagogastric adenocarcinoma, inhibition of the vascular endothelial growth factor (VEGF) pathway via the anti–VEGFR-2 antibody ramucirumab increases response, progression-free survival (PFS) and overall survival (OS) when combined with second-line treatment with paclitaxel. The multitargeted tyrosine kinase inhibitor regorafenib targets VEGFR and other pathways and has effectiveness in chemotherapy-refractory colorectal cancer.

Investigators now report results of the industry-sponsored, randomized, double-blind, placebo-controlled INTEGRATE IIa trial evaluating regorafenib (160 mg daily for 21 days of 28-day cycles) in patients with chemotherapy-refractory esophagogastric adenocarcinoma. Of the 251 patients enrolled, 63% were treated in Asia; 73% had gastric primaries; 42% had received a prior VEGF inhibitor; 59% had received two and 40% had received three or more lines of prior chemotherapy. For the analysis of OS, the primary endpoint, results were pooled with those from INTEGRATE I, a prior randomized, placebo-controlled, phase II trial in 147 patients.

Continue reading “A Potential New Treatment Option for Chemotherapy-Refractory Gastric Cancer” »

Change can take many forms.

Newly discovered altermagnetism at the Swiss Light Source SLS opens door to new physics & spintronics. Learn about this new addition to magnetic family!

Mapping the geometry of quantum worlds: measuring the quantum geometric tensor in solids.

Quantum states are like complex shapes in a hidden world, and understanding their geometry is key to unlocking the mysteries of modern physics. One of the most important tools for studying this geometry is the quantum geometric tensor (QGT). This mathematical object reveals how quantum states “curve” and interact, shaping phenomena ranging from exotic materials to groundbreaking technologies.

The QGT has two parts, each with distinct significance:

Continue reading “Physicists measure quantum geometry for first time” »

The most common form – obstructive sleep apnoea – happens when the walls of the throat relax and narrow or close, with symptoms including choking noises, loud snoring and waking up a lot.

The three-hour procedure to fit Nyxoah’s Genio implant was carried out by medics at University College London Hospitals NHS foundation trust (UCLH) this month.

One of the two patients, Natalie Boller, 63, was feeling better within days and will return to the clinic to have the device activated in the coming weeks.

The Nancy Grace Roman Space Telescope team at NASA has completed the integration of the telescope and its instruments onto the carrier, a significant milestone in the assembly process.

With the Coronagraph Instrument and the Optical Telescope Assembly in place, the Roman telescope is equipped to explore a vast array of astronomical phenomena, including exoplanets and cosmic mysteries like dark energy and dark matter. The Wide Field Instrument, a powerful 300-megapixel infrared camera, will enhance the telescope’s capability to survey the universe extensively. The project is on schedule for a 2026 completion and a 2027 launch.

Integration of roman space telescope components.

A NASA-led study reveals that the pattern of rainfall throughout the year—specifically the frequency and intensity of rain events—is nearly as significant to global vegetation health as the total amount of annual rainfall.

The research indicates that less frequent but heavier rainfalls can benefit plants in arid regions like the U.S. Southwest, while potentially harming those in wetter ecosystems such as the Central American rainforests due to longer intervals of dryness.

Continue reading “NASA Finds Rain’s Timing Is a Game-Changer for Plants Worldwide” »

Researchers at NASAs Armstrong Center are advancing an atmospheric probe for potential space missions.

Utilizing innovative designs based on past aircraft research, the team has successfully tested the probe, planning further improvements to increase its functionality and data-gathering capabilities.

Continue reading “NASA’s Atmospheric Probe Soars in Game-Changing Test Flight” »

Researchers at the University of Virginia have made significant advancements in understanding how heat flows through thin metal films, critical for designing more efficient computer chips.

This study confirms Matthiessen’s rule at the nanoscale, enhancing heat management in ultra-thin copper films used in next-generation devices, thereby improving performance and sustainability.

Breakthrough in Chip Technology.