Lifeboat Foundation: Safeguarding Humanity
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Summary: A new study explores how the human brain constructs emotions, regardless of sensory input.

By analyzing brain activity in individuals with and without sensory deprivations while they experienced the film 101 Dalmatians, researchers discovered that emotions are represented in the brain through an abstract coding system that transcends sensory modalities. This system involves a distributed network, including the ventromedial prefrontal cortex, which stores abstract representations of emotions.

The findings challenge traditional views on emotion and perception, suggesting that our emotional experiences are not solely dictated by our immediate sensory input but are instead constructed by the brain in a more abstract manner.

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A research team has successfully synthesized a metal nanocluster and determined its crystal structure. Their study provides experimental evidence for understanding and designing nanoclusters with specific properties at the atomic level. Metal nanoclusters have wide-ranging applications in the biomedical field.

Their work is published in the journal Polyoxometalates.

Scientists have shown interest in ligand-protected atomically precise nanoclusters because they have definite atomic structures and exceptional physical and chemical properties. These properties include attributes such as luminescence, chirality, electrochemistry, and catalysis.

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Retrotransposons can insert new genes into a “safe harbor” in the genome, complementing CRISPR gene editing.

The recent greenlighting of a CRISPR-Cas9 treatment for sickle cell disease underscores the efficacy of gene editing technologies in deactivating genes to heal inherited illnesses. However, the capability to integrate entire genes into the human genome as replacements for faulty or harmful ones remains unachievable.

A new technique that employs a retrotransposon from birds to insert genes into the genome holds more promise for gene therapy, since it inserts genes into a “safe harbor” in the human genome where the insertion won’t disrupt essential genes or lead to cancer.

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ABOVE: After years of research, brain organoids now come close to mimicking endogenous brain cells. © iStock, StockSnap.

As a developmental neurobiologist at Harvard University, Paola Arlotta spends most of her time thinking about how the brain develops, how it functions, and what goes wrong in the context of neurological disease. Using human brain organoids as a model for brain development and disease research has been a game changer, providing Arlotta a novel view into brain pathologies that form in utero.

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Gartner predicts, too, that by 2027 15% of EV companies founded since the last decade will be acquired or bankrupt. “This does not mean the EV sector is crumbling,” said Pedro Pacheco, vice president of research at Gartner. “It is simply entering a new phase where companies with the best products and services will win over the remaining.” Of course, at least 18 EV and battery startups that went public in recent years and attracted huge investments are now struggling for cash, with plenty going belly up, including Lordstown Motors and Proterra.

Still, new innovations will push BEV price down, Gartner states. “New OEM incumbents want to heavily redefine the status quo in automotive,” he added. “They brought new innovations that simplify production costs such as centralized vehicle architecture or the introduction of gigacastings that help reduce manufacturing cost and assembly time, which legacy automakers had no choice to adopt to survive.”

By 2027, next-gen BEVs will be cheaper to make than comparable ICE vehicles, with production costs dropping faster than battery costs. But there’s a rub: Repair costs will be more expensive, Gartner says. By 2027, it predicts that the average cost of an EV body and battery “serious accident repair” will increase by 30%.

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