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Research utilizing AI tool AlphaFold has revealed a new protein complex that initiates the fertilization process between sperm and egg, shedding light on the molecular interactions essential for successful fertilization.

Genetic research has uncovered many proteins involved in the initial contact between sperm and egg. However, direct proof of how these proteins bind or form complexes to enable fertilization remained unclear. Now, Andrea Pauli’s lab at the IMP, working with international collaborators, has combined AI-driven structural predictions with experimental evidence to reveal a key fertilization complex. Their findings, based on studies in zebrafish, mice, and human cells, were published in the journal Cell.

Fertilization is the first step in forming an embryo, starting with the sperm’s journey toward the egg, guided by chemical signals. When the sperm reaches the egg, it binds to the egg’s surface through specific protein interactions. This binding readies their membranes to merge, allowing their genetic material to combine and create a zygote—a single cell that will eventually develop into a new organism.

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SpaceX’s next Starship megarocket now has a license to fly.

The U.S. Federal Aviation Administration (FAA) on Tuesday (Dec. 17) issued a launch license for SpaceX’s upcoming Starship Flight 7 test flight, clearing the way for the company’s next launch of the world’s largest rocket from South Texas. The launch license comes on the heels of several Starship engine tests by SpaceX to check the flight readiness of its seventh Ship spacecraft and Super Heavy rocket booster.

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Distant, ancient galaxies are giving scientists more hints that a mysterious force called dark energy may not be what they thought.

Astronomers know that the universe is being pushed apart at an accelerating rate and they have puzzled for decades over what could possibly be speeding everything up. They theorize that a powerful, constant force is at play, one that fits nicely with the main mathematical model that describes how the universe behaves. But they can’t see it and they don’t know where it comes from, so they call it dark energy.

It is so vast it is thought to make up nearly 70% of the universe—while ordinary matter like all the stars and planets and people make up just 5%.

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In 1956, a group of pioneering minds gathered at Dartmouth College to define what we now call artificial intelligence (AI). Even in the early 1990s when colleagues and I were working for early-stage expert systems software companies, the notion that machines could mimic human intelligence was an audacious one. Today, AI drives businesses, automates processes, creates content, and personalizes experiences in every industry. It aids and abets more economic activity than we “ignorant savages” (as one of the founding fathers of AI, Marvin Minsky, referred to our coterie) could have ever imagined. Admittedly, the journey is still early—a journey that may take us from narrow AI to artificial general intelligence (AGI) and ultimately to artificial superintelligence (ASI).

As business and technology leaders, it’s crucial to understand what’s coming: where AI is headed, how far off AGI and ASI might be, and what opportunities and risks lie ahead. To ignore this evolution would be like a factory owner in 1900 dismissing electricity as a passing trend.

Let’s first take stock of where we are. Modern AI is narrow AI —technologies built to handle specific tasks. Whether it’s a large language model (LLM) chatbot responding to customers, algorithms optimizing supply chains, or systems predicting loan defaults, today’s AI excels at isolated functions.

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PHOENIX — Mayo Clinic announces the results of an innovative treatment approach that may offer improvement in overall survival in older patients with newly diagnosed glioblastoma while maintaining quality of life. Glioblastoma is the most lethal type of primary brain cancer due to its aggressive nature and its treatment-resistant characteristics. It is the most common form of primary brain cancer. Each year an estimated 14,500 people in the U.S. are diagnosed with the disease. Results of Mayo Clinic’s phase 2, single-arm study are published in The Lancet Oncology.

Sujay Vora, M.D., radiation oncologist at Mayo Clinic, led a team of researchers investigating the use of short-course hypofractionated proton beam therapy incorporating advanced imaging techniques in patients over the age of 65 with newly diagnosed World Health Organization (WHO) grade 4, malignant glioblastoma.

Results showed that 56% of participants were alive after 12 months and the median overall survival was 13.1 months.” As compared to prior phase 3 studies in an older population having a median survival of only six to nine months, these results are promising,” says Dr. Vora. “In some cases, patients with tumors that have favorable genetics lived even longer, with a median survival of 22 months. We are very excited about these results.”

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Jupiter’s moon Io is the most volcanically active body in our Solar System, with around 400 volcanoes and extensive lava flows spread across its surface – but contrary to what scientists thought, a new study suggests this geological chaos is not powered by a global, moonwide ocean of magma below the surface.

Using images snapped by NASA’s Juno spacecraft, gravitational measurements, and historical data about Io’s tidal deformations, an international team of researchers has determined that the moon’s volcanoes are powered by a scattering of magma chambers in an otherwise solid mantle.

The findings counter previous theories about how Io’s volcanoes are powered, and point to a mostly solid mantle for the moon. With magma oceans believed to be present on many worlds, especially early in their formation – including our own Moon – we may need to rethink how planets form and evolve.

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Einstein’s theory of gravity, general relativity, has passed all tests with predictions that are spot-on. One prediction that remains is “gravitational wave memory”—the prediction that a passing gravitational wave will permanently change the distance between cosmic objects.

Supernovae—collapsing stars that explode outward—are thought to be generators of , though none have yet been definitively detected by the gravitational wave interferometers on Earth. Nor has the gravitational wave memory effect been seen, from mergers or supernovae, due to the limited sensitivity of interferometers below wave frequencies of 10 hertz.

But now a new study presents an approach to detecting the effect using currently existing gravitational wave observatories. The paper is published in Physical Review Letters.

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