Lifeboat Foundation

The latest episode of the Huberman Lab Podcast is all about the aging process and how to slow, halt or reverse it. My guest is Dr. David Sinclair from Harvard Medical School.

We discuss:

• Epigenetics.
• Fasting, breaking fasts.
• Nutrition, artificial sweeteners.
• How puberty impacts aging.
• Resveratrol, caffeine, electrolytes.
• NAD, NMN, Metformin, Berberine.
• Specific supplementation protocols.

𝐔𝐧𝐤𝐧𝐨𝐰𝐧 𝐯𝐨𝐢𝐜𝐞𝐬 𝐬𝐩𝐚𝐫𝐤 𝐦𝐨𝐫𝐞 𝐛𝐫𝐚𝐢𝐧 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐢𝐧 𝐬𝐥𝐞𝐞𝐩 𝐭𝐡𝐚𝐧 𝐟𝐚𝐦𝐢𝐥𝐢𝐚𝐫 𝐨𝐧𝐞𝐬

By Jason Arunn Murugesu.

The sleeping brain is more active if it hears unfamiliar voices rather than familiar ones. The finding suggests that we can process information about our environments even in the depths of sleep.

Continue reading “Unknown voices spark more brain activity in sleep than familiar ones” »

Viruses can be wily adapters, changing their identities to find new hosts and thwart efforts to stop them. That’s why University of Wisconsin-Madison researchers and their collaborators are making progress toward developing universal vaccines against some the planet’s most harmful pathogens, including the virus family responsible for the COVID-19 pandemic.

Last fall, the National Institutes of Health announced it was investing in three teams working to develop a vaccine that would simultaneously work against a broad range of coronaviruses. Among them is a research collaboration, the Pan-Coronavirus Vaccine consortium, led by UW-Madison School of Veterinary Medicine Professor of Pathobiological Sciences Yoshihiro Kawaoka.

“This pan-coronavirus vaccine is basically preparing for the future,” Kawaoka says.

Continue reading “UW–Madison researchers lead effort to create a universal coronavirus vaccine” »

Although multimorbidity differs for each person, we know that patients tend to suffer from the same groups of diseases — known as “clusters”. This suggests that each cluster may share a common underlying cause. For example, a person with multimorbidity may suffer from heart problems (such as heart disease and high blood pressure) and diabetes, which may all stem from the same cause — such as obesity.

Identifying and treating the cause of a patient’s disease clusters would allow us to more effectively combat several — or even all — of the diseases a patient has using a single treatment. This would both reduce the number of medical appointments a person needs to attend and the number of medications they may need to take.

Ageing is the single biggest risk factor for developing multimorbidity.

Continue reading “Tackling ageing may be best way to prevent multiple chronic conditions from developing in older people” »

Like so much in chronic disease, Alzheimer’s is complicated: “once you have seen one person with Alzheimer’s, you have seen one person with Alzheimer’s. In other words, Alzheimer’s disease (AD) is a heterogeneous disease which may present and progress differently depending on the person and the factors contributing to the disease pathology. As such, there is no paint-by-numbers approach to targeted treatment. Researchers in the field are thus motivated to figure out a way to categorize AD in order to guide more individualized approaches to patient care and help anticipate disease trajectory.”

A proposal for 4 subtypes of Alzheimer’s disease.

According to recent studies, more than a third of astronauts become momentarily anemic during space travel due to the enormous loss of red blood cells, including that of Tim Peake. Since the symptoms only appear with gravity, this does not cause problems until they arrive.

A new study reveals that populating other planets, like those envisioned by entrepreneur Elon Musk, may be more complex than previously assumed, based on the discovery of “space anemia.”

In addition, they suggested that it might deter those predisposed to heart illness, such as angina, from participating in the growing space tourism industry.

𝙃𝙤𝙬 𝙙𝙤𝙚𝙨 𝙤𝙪𝙧 𝙫𝙞𝙨𝙪𝙖𝙡 𝙨𝙮𝙨𝙩𝙚𝙢 𝙖𝙘𝙝𝙞𝙚𝙫𝙚 𝙩𝙝𝙞𝙨 𝙖𝙥𝙥𝙖𝙧𝙚𝙣𝙩 𝙨𝙩𝙖𝙗𝙞𝙡𝙞𝙩𝙮? 𝙉𝙚𝙬 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝 𝙗𝙮 𝙩𝙝𝙚 𝙐𝘾 𝘽𝙚𝙧𝙠𝙚𝙡𝙚𝙮 𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩𝙨 𝙧𝙚𝙫𝙚𝙖𝙡𝙨 𝙩𝙝𝙖𝙩 𝙤𝙪𝙧 𝙗𝙧𝙖𝙞𝙣𝙨 𝙖𝙧𝙚 𝙘𝙤𝙣𝙨𝙩𝙖𝙣𝙩𝙡𝙮 𝙪𝙥𝙡𝙤𝙖𝙙𝙞𝙣𝙜 𝙧𝙞𝙘𝙝, 𝙫𝙞𝙨𝙪𝙖𝙡 𝙨𝙩𝙞𝙢𝙪𝙡𝙞. 𝙒𝙚 𝙨𝙚𝙚 𝙚𝙖𝙧𝙡𝙞𝙚𝙧 𝙫𝙚𝙧𝙨𝙞𝙤𝙣𝙨 𝙞𝙣𝙨𝙩𝙚𝙖𝙙 𝙤𝙛 𝙨𝙚𝙚𝙞𝙣𝙜 𝙩𝙝𝙚 𝙡𝙖𝙩𝙚𝙨𝙩 𝙞𝙢𝙖𝙜𝙚 𝙗𝙚𝙘𝙖𝙪𝙨𝙚 𝙤𝙪𝙧 𝙗𝙧𝙖𝙞𝙣’𝙨 𝙧𝙚𝙛𝙧𝙚𝙨𝙝 𝙩𝙞𝙢𝙚 𝙞𝙨 𝙖𝙗𝙤𝙪𝙩 15 𝙨𝙚𝙘𝙤𝙣𝙙𝙨.… See more.

The Neuro-Network.

Continue reading “Our brains take a little while to update, study” »

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis–the process of cell death that is usually caused by infections and results in excess inflammation in the body–and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.

The discovery, which is reported in Nature Communications, means that scientists have a new way to study diseases that are related to malfunctioning cell death processes, like some cancers, and infections that can be complicated by out-of-control inflammation caused by the process. These infections include sepsis, for example, and acute respiratory distress syndrome, which is among the major complications of COVID-19 illness.

Pyroptosis is a series of biochemical reactions that uses gasdermin, a protein, to open large pores in the cell membrane and destabilize the cell. To understand more about this process, the UIC researchers designed an “optogenetic” gasdermin by genetically engineering the protein to respond to light.

Continue reading “Scientists uncover new information about cellular death process, previously thought to be irreversible” »

𝐓𝐞𝐜𝐡 𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐬𝐭:

The Neuro-Network.

𝐀𝐧 𝐚𝐫𝐭𝐢𝐟𝐢𝐜𝐢𝐚𝐥 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞 𝐰𝐢𝐭𝐡 𝐬𝐮𝐩𝐞𝐫𝐩𝐨𝐰𝐞𝐫𝐬

Continue reading “An artificial molecule with superpowers” »