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Researchers identify RBFox1 as a key intrinsic regulator of heart muscle cell maturation, overcoming a major limitation in cardiac regenerative therapy and disease modelling and demonstrating for the first time that RNA splicing control can significantly impact this process.

Scientists led by Duke-NUS Medical School in Singapore and the University of California, Los Angeles, (UCLA) in the United States have discovered a new control mechanism that can drive the maturation of human stem cell-derived heart muscle cells, providing fresh insight into the maturation process of heart muscle cells from fetal to adult form.

After birth, heart muscle cells undergo extensive changes to become fully mature adult cells, altering their form, function and physiology.

Nanoparticles seem the future of electronics, at least until the next big thing.


Nano-engineered oxides are very important for the development of next-generation catalysts and microelectronics. Recently, metal exsolution from oxides has emerged as a promising nano-structuring tool to fabricate nanoparticle-decorated oxides. However, controlling the size, density, composition, and location of exsolved nanoparticles remains a challenge, limiting the ultimate performance achievable by these nanostructures.

The following nanoparticle production control was achieved: 1. ion sputtering can controllably reduce the size of surface exsolved nanoparticles down to 2 nm, which are among the smallest values reported in the literature thus far. 2. implanted metal ions can tailor the composition of nanoparticles exsolved both at the surface and in the bulk, providing a convenient and direct way to synthesize exsolved nanoparticles with alloyed compositions. 3. irradiation-induced lattice defects can catalyze the nucleation of nanoparticles, and this enables controlling the density and location of exsolved nanoparticles at specific sample locations using ion irradiation.

MIT Researchers worked with the Brookhaven National Lab to perform this work. The work demonstrates control over key properties leading to better performance. Fuel and electrolysis cells both involve electrochemical reactions through three principal parts: two electrodes (a cathode and anode) separated by an electrolyte. The difference between the two cells is that the reactions involved run in reverse. The electrodes are coated with catalysts, or materials that make the reactions involved go faster. But a critical catalyst made of metal-oxide materials has been limited by challenges including low durability. This works has improved the critical fuel cell catalyst. Metallic nanoparticles serve as catalysts in many, many reactions, including the important reaction of splitting water to generate hydrogen for energy storage.

Over the past decades, electronics engineers have created devices of various shapes and with increasingly sophisticated designs. This includes electronics that can be folded onto themselves, such as foldable phones, along with various other compressible devices.

Researchers at Ajou University and other institutes in South Korea recently introduced a new design for developing crumple-recoverable electronics, or in other words, electronics that can recover their original shape after being crumpled or compressed onto themselves to reduce their size. This design, outlined in a paper published in Nature Electronics, draws inspiration from the mechanism that allows butterflies to unfold their wings when leaving their cocoon.

“Nature is rich of different plants and animals, each of which survived by adapting and evolving in extreme environments,” Seungyong Han, co-author of the paper, told Tech Xplore. “Personally, I’ve always thought that by closely observing these phenomena, we can find clues to solve various problems in modern society. Also, by approaching this from an engineering perspective, I believed we could achieve results that may improve people’s daily lives.”

Generative AI provoked a lot of discussion last year around images, text and video, but it may soon affect the gaming industry as well. Square Enix said it plans to be “aggressively applying” AI and other cutting-edge tech in 2024 to “create new forms of content,” according to president Takashi Kiryu’s New Year’s letter.

“Artificial intelligence (AI) and its potential implications had for some time largely been subjects of academic debate,” he said. “However, the introduction of ChatGPT, which allows anyone to easily produce writing or translations or to engage in text-based dialogue, sparked the rapid spread of generative AIs. I believe that generative AI has the potential not only to reshape what we create, but also to fundamentally change the processes by which we create, including programming.”

The company will start by using it to improve productivity in development and assist in marketing. “In the longer term, we hope to leverage those technologies to create new forms of content for consumers, as we believe that technological innovation represents business opportunities,” Kiryu added. Square Enix also plans to build more immersive AR and VR experiences, including “new forms of content that fuse the real world and virtual worlds.”

SYDNEY — With fangs that could pierce a human fingernail, the largest male specimen of the world’s most venomous arachnid has found a new home at the Australian Reptile Park where it will help save lives after a member of the public discovered it by chance.

The deadly Sydney funnel-web spider dubbed “Hercules” was found on the Central Coast, about 50 miles north of Sydney, and was initially given to a local hospital, the Australian Reptile Park said in a statement Thursday.

Spider experts from the nearby park retrieved it and soon realized it was the largest male specimen ever received from the public in Australia.