Lifeboat Foundation

Each cell in the body stores its genetic information in DNA in a stable and protected form that is readily accessible for the cell to carry on its activities. Nevertheless, mutations—changes in genetic information—occur throughout the human genome and can have a powerful influence on human health and evolution.

“Our team is interested in a classical question about mutation—why do mutation rates in the genome vary so tremendously from one DNA location to another? We just do not have a clear understanding of why this occurs,” said Dr. Md. Abul Hassan Samee, assistant professor of integrative physiology at Baylor College of Medicine and corresponding author of the work.

Previous studies have shown that the DNA sequences flanking a mutated position—the sequence context—play a strong role in the mutation rate. “But this explanation still leaves unanswered questions,” Samee said. “For example, one type of mutation occurs frequently in a specific sequence context while a different type of mutation occurs infrequently in that same sequence context. So, we think that a different mechanism could explain how mutation rates vary in the genome. We know that each building block or base that makes up a DNA sequence has its own 3D chemical shape. We proposed, therefore, that there is a connection between DNA shape and mutations rates, and this paper shows that our idea was correct.”

Heterochronic parabiosis ameliorates age-related diseases in mice, but how it affects epigenetic aging and long-term health was not known. Here, the authors show that in mice exposure to young circulation leads to reduced epigenetic aging, an effect that persists for several months after removing the youthful circulation.

Yang and co-workers state that “using inducible changes to the epigenome, we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that a loss of epigenetic information is a reversible cause of aging.” There is extensive evidence that the key reagent, restriction endonuclease I-PpoI, is cytotoxic. Moreover, the corresponding author published two papers—neither cited—showing that I-PpoI targeted to specific cell types causes a p53 response and cell elimination within a month. Despite globally inducing I-PpoI activation for seven times as long as required to induce a progeric effect, no analysis of mice during this critical window was presented. No significant conclusion of Yang was demonstrated.

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SHINE Technologies.

With the world looking for cleaner ways to meet its energy demands, nuclear power is gaining favor once again as a low-carbon source of energy. Companies are also focused on harnessing energy from nuclear fusion instead, which does not raise concerns about nuclear waste.

In the fascinating landscape tech realm, quantum computing stock opportunities could prove to be incredibly lucrative over time. The notion of quantum computing, born over two decades ago, is now gaining solid traction on The Street. Moreover, the technology, rooted in the mysteries of quantum mechanics, aims to boost computing speeds significantly.

The advancements in quantum computing are impossible to ignore, with continuous improvements and decreasing development costs. Moreover, the sector’s convergence with cloud computing opens doors for broader accessibility among researchers and software developers.

Furthermore, as the digital economy and artificial intelligence sectors grow, global spending on cloud computing is expected to reach a whopping $1 trillion annually within the next decade. Quantum computing appears to be on the cusp of becoming a game-changer, and it might be the most opportune time to load up on affordable quantum computing stocks.

In Switzerland, there’s a new cryonics company: and they invited me to have a look around. I had questions: legal, practical, and ethical, and I want to be clear: this is not an endorsement. I just wasn’t going to turn down that invitation. ■ Tomorrow Bio: https://www.tomorrow.bio/

Camera: Martin Bäbler.

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A study has revealed that AI can be used to detect cancer from mammogram screenings and could improve efficiencies and reduce workloads for health workers.

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Earl.