Ultrasonic standing waves can be used to manipulate the position and control the movement of levitated objects through acoustic radiation forces. Within this co
Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects approximately 1% of people over the age of 60 and 5% of those over the age of 85. Current drugs for Parkinson’s disease mainly affect the symptoms and cannot stop its progression. Nanotechnology provides a solution to address some challenges in therapy, such as overcoming the blood-brain barrier (BBB), adverse pharmacokinetics, and the limited bioavailability of therapeutics. The reformulation of drugs into nanoparticles (NPs) can improve their biodistribution, protect them from degradation, reduce the required dose, and ensure target accumulation. Furthermore, appropriately designed nanoparticles enable the combination of diagnosis and therapy with a single nanoagent.
In recent years, gold nanoparticles (AuNPs) have been studied with increasing interest due to their intrinsic nanozyme activity. They can mimic the action of superoxide dismutase, catalase, and peroxidase. The use of 13-nm gold nanoparticles (CNM-Au8®) in bicarbonate solution is being studied as a potential treatment for Parkinson’s disease and other neurological illnesses. CNM-Au8® improves remyelination and motor functions in experimental animals.
Among the many techniques for nanoparticle synthesis, green synthesis is increasingly used due to its simplicity and therapeutic potential. Green synthesis relies on natural and environmentally friendly materials, such as plant extracts, to reduce metal ions and form nanoparticles. Moreover, the presence of bioactive plant compounds on their surface increases the therapeutic potential of these nanoparticles. The present article reviews the possibilities of nanoparticles obtained by green synthesis to combine the therapeutic effects of plant components with gold.
Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease
Posted in biotech/medical | Leave a Comment on Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease
Biomarker for Parkinson’s disease using single extracellular vesicle detection assay.
Detecting minute amounts of neuronally derived biomarkers in the massive protein excess of easily accessible biofluids such as blood is challenging.
The researchers develop a droplet-based microfluidic immunoassay for multiplexed quantification of membrane associated proteins at single extracellular-vesicle (EV) resolution.
They identify membrane-associated a-synuclein on the surface of neuronal EVs and demonstrate that it is increased under pathological conditions and in individuals at risk of or with Parkinson’s disease. https://sciencemission.com/Single-extracellular-vesicle-detection-assay
Yan et al. develop a droplet-based microfluidic immunoassay for multiplexed quantification of membrane-associated proteins at single-extracellular-vesicle (EV) resolution. They identify membrane-associated α-synuclein on the surface of neuronal EVs and demonstrate that it is increased under pathological conditions and in individuals at risk of or with Parkinson’s disease.
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An extensive report on the future of AI research indicated that there’s skepticism about current approaches to AGI.
Cases of the fungal infection Candida auris are rising rapidly and coming from more sources too, a new US study reveals.
C. auris was first reported in the US in 2016 and is considered an “urgent antimicrobial resistance threat” in hospitals, according to the Centers for Disease Control and Prevention (CDC).
Focusing on a large health system in Miami, Florida, the new research found that reported clinical cases had risen from 5 in 2019 to 115 in 2023 – a considerable jump of 2,200 percent in four years.
A bioelectric capsule tricks the brain into feeling full by activating the stomach’s stretch receptors.
An investigational drug for glioblastoma more than doubled survival and progression-free time compared to standard rates. | Drug Discovery And Development
To compete in an increasingly complex market, companies will need to unleash distinctive capabilities, reduce low-value work, speed up decision-making, and harness AI and digital.
Biological systems, once thought too chaotic for quantum effects, may be quietly leveraging quantum mechanics to process information faster than anything man-made.
New research suggests this isn’t just happening in brains, but across all life, including bacteria and plants.
Schrödinger’s legacy inspires a quantum leap.