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A team of Children’s Medical Research Institute (CMRI) scientists has identified a new method for producing a therapeutic product that has the potential to improve the treatment of cancer.

The work by Associate Professor Leszek Lisowski and his Translational Vectorology Research Unit is published in the journal Molecular Therapy.

Chimeric antigen receptor (CAR) T cells, also known as CAR T therapies, are a relatively new form of treatment showing very exciting results for several types of cancer. While initially validated for the treatment of B cell malignancies, especially acute lymphoblastic leukemia (ALL), the technology has also shown promise for other cancer types, including solid tumors.

People with breathing problems during sleep may have a larger hippocampus, the area of the brain responsible for memory and thinking, according to a study published in the December 18, 2024, online issue of Neurology.

The study, which included mostly Latino people, also found that those with lower oxygen levels during sleep had changes in the deep parts of the brain, the white matter, a common finding of decreased brain health that develops with age.

Sleep disordered breathing is a range of conditions that cause abnormal breathing during sleep, including snoring and obstructive sleep apnea. Obstructive sleep apnea is when a person stops breathing five or more times per hour. When breathing stops, it can lower oxygen levels, affecting the brain.

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We often imagine that our planet might be a sentient entity — Gaia — but could something like this evolve under known science? And might a conscious world be something we might create in the future?

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Diving deep into the relationship between a concept’s frequency in the training dataset and the ability of a model to imitate it. We seek to determine the point at which a model was trained on enough instances to imitate a concept — the imitation threshold.

Modern materials must be recyclable and sustainable. Consumer electronics is no exception, with organic light-emitting diodes (OLEDs) taking over modern televisions and portable device displays. However, the development of suitable materials—from the synthesis of molecules to the production of display components—is very time-consuming.

Scientists led by Denis Andrienko of the Max Planck Institute for Polymer Research and Falk May from Display Solutions at Merck have now developed a simulation method that could significantly speed up the development of new materials.

High contrast and low power consumption are key features of innovative organic light-emitting diodes. OLEDs use thin films of organic molecules, i.e. carbon-containing molecules, to achieve these goals.

A new visual recognition approach improved a machine learning technique’s ability to both identify an object and how it is oriented in space, according to a study presented in October at the European Conference on Computer Vision in Milan, Italy.

Self-supervised learning is a machine learning approach that trains on unlabeled data, extending generalizability to real-world data. While it excels at identifying objects, a task called semantic classification, it may struggle to recognize objects in new poses.

This weakness quickly becomes a problem in situations like autonomous vehicle navigation, where an algorithm must assess whether an approaching car is a head-on collision threat or side-oriented and just passing by.

Scientists are studying the genes of “superagers” in hopes of identifying targets for therapies and treatments to help people live longer, healthier lives.

Through its commitment to international nuclear nonproliferation — a mission focused on limiting the spread of nuclear weapons and sensitive technology while working to promote peaceful use of nuclear science and technology — the United States maintains a constant vigilance aimed at reducing the threat of nuclear and radiological terrorism worldwide.

With extensive research into both basic and applied uranium science, as well as internationally deployed operational solutions, the Department of Energy’s Oak Ridge National Laboratory is uniquely positioned to contribute its comprehensive capabilities toward advancing the U.S. nonproliferation mission.

In 1943, seemingly overnight, ORNL emerged from a rural Tennessee valley as the site of the world’s first continuously operating nuclear reactor, in support of U.S. efforts to end World War II. ORNL’s mission soon shifted into peacetime applications, harnessing nuclear science for medical treatments, power generation and breakthroughs in materials, biological and computational sciences.