Lifeboat Foundation

Cisco Systems senior visioneer, Annie Hardy, joins me to discuss AI and the future of the internet.

“We are all now connected to the internet, like neurons in a giant brain.” –Stephen Hawking.

Unless you are living in a remote cabin completely off-grid, it has reached the point where you cannot avoid artificial intelligence. It’s in our search engines, it’s on our phones, it’s on the social media on our phones. It’s permeating the internet at a breakneck pace.

Continue reading “#66–Artificial Intelligence and the Future of the Internet, with Annie Hardy” »

Scientists at Newcastle University have created a new lung scanning method that shows real-time changes in lung function. This technique tracks airflow in and out of the lungs, particularly in patients with asthma, chronic obstructive pulmonary disease (COPD), or those who have had a lung transplant. This innovation could help doctors detect declines in lung function earlier.

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Genesis integrates various physics solvers and their coupling into a unified framework.

AI robotics training has been increased tremendously with the help of a new tool. Called ‘Genesis’, the tool is a new open-source computer simulation system.

Unveiled by a large group of university and private industry researchers, the system reportedly lets robots practice tasks in simulated reality 430,000 times faster than in the real world.

Continue reading “New physics engine lets robots practice tasks 430,000x faster” »

The growth of maize, sugarcane and sorghum has been greatly boosted by modifying the plants to take advantage of higher carbon dioxide levels now found in the air.

This was done by simply increasing the activity of two genes, says Coralie Salesse-Smith at the University of Illinois. The finding should lead to the creation of new varieties whose yields go up as CO₂ levels continue to rise.

For most of the time that photosynthetic cells that turn sunlight into food have existed, atmospheric levels of CO₂ have been much higher (and the planet has been much hotter). As CO₂ levels fell particularly low from about 35 million years ago, it exacerbated a fundamental flaw in photosynthesis that involves probably the most abundant protein on the planet, called rubisco.

Continue reading “Genetic tweak to three key crops massively boosts their growth” »

Using an AI tool, researchers at Karolinska Institutet have analyzed brain images from 70-year-olds and estimated their brains’ biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated with an older-looking brain, while healthy lifestyles were linked to brains with a younger appearance.

The results are presented in a paper titled “Biological brain age and resilience in cognitively unimpaired 70-year-old individuals” in Alzheimer’s & Dementia.

Every year, over 20,000 people in Sweden develop some form of dementia, with Alzheimer’s disease accounting for approximately two-thirds of cases. However, the speed at which the brain ages is affected by various risk and health factors.

Furthermore, GDF-15 levels have been positively associated with the aging process. In fact, Tanaka et al. (Tanaka et al. 2018) showed that this cytokine had the strongest positive correlation with age in humans, and several reports describe higher levels of GDF-15 in older individuals (Semba et al. 2020; Doerstling et al. 2018; Liu et al. 2020). Aging is characterized by a decline in physiological function and changes in body composition, being a major risk factor for a variety of chronic diseases. As such, GDF-15 is also associated with several age-related diseases, including cardiovascular disease (Echouffo-Tcheugui et al. 2021), cancer (Wischhusen et al. 2020), metabolic syndrome (Ho et al. 2023; Carballo-Casla et al. 2022), or diabetes (Ouyang et al. 2020; Merchant et al. 2023), among others (Candia et al. 2021; Iglesias et al. 2023). In addition, it has been proposed as a biomarker for the risk of death in patients with cardiovascular conditions and an accurate all-cause mortality marker (Candia et al. 2021; Iglesias et al. 2023; Nopp et al. 2021). GDF-15 has also been positively associated with deteriorated muscle function and sarcopenia (Semba et al. 2020; Kim et al. 2022, 2020; Nakajima et al. 2019; Lee et al. 2022), a highly prevalent condition among the elderly that increases the risk of frailty (Picca et al. 2020).

It is widely accepted that human aging may be influenced by epigenetic alterations (López-Otín et al. 2023). In this sense, age biomarkers based on DNA methylation have proven useful in predicting the risk of age-related diseases and mortality (Fransquet et al. 2019). Among several developed epigenetic clocks, DNAm GrimAge has shown a higher prediction capacity of mortality and morbidity risk (Lu et al. 2022). Notably, GDF-15 is one of the markers included for the calculation of this clock (Lu et al. 2019). Thus, understanding the interplay between GDF-15 and aging can be crucial for improving the assessment of and management of age-associated conditions.

For all this, the aim of this study was to characterize the changes in circulating GDF-15 levels with age in a population of healthy individuals from the Balearic Islands and investigate its potential associations with different epigenetic and biological clocks, physical performance and other age-related biomarkers.

The mystery of dark matter could be solved in as little as 10 seconds.

When the next nearby supernova goes off, any gamma-ray telescope pointing in the right direction might be treated to more than a light show – it could quickly confirm the existence of one of the most promising dark matter candidates.

Astrophysicists at the University of California, Berkeley predict that within the first 10 seconds of a supernova, enough hypothetical particles called axions could be emitted to prove they exist in a relative blink.

Mayo Clinic researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence and aging in both mice and humans. Experiments show that IL-23R levels in the bloodstream increase with age and can decrease, reflecting senescent cell clearing, with senolytic therapies.

Cellular senescence occurs when cells stop dividing but do not trigger apoptosis mechanisms that would allow them to die naturally. Instead, they are stuck in a zombie-like state, where they still have the urge to feed and carry out metabolic activities, but with increasingly incoherent cell signaling and increased pro-inflammatory cytokine secretions.

Senescent cell activity has been linked to several age-related diseases, including those of the immune, cardiovascular, metabolic, pulmonary, musculoskeletal and neurological systems.

AI’s impact extends beyond operational efficiency; it is vital in boosting job satisfaction and retention among hourly workers. Inconsistent scheduling and poor communication have long been pain points for this group, especially as one in five Gen-Z workers juggles multiple jobs (poly-employment). AI will directly address the challenges associated with this shift through predictive scheduling and real-time updates, providing clear and reliable expectations. It’s truly a win-win: When employees are on time, customers receive the quality service they deserve.

The World Economic Forum predicts that 23% of global jobs will change in the next five years due to industry shifts, including AI. Through AI, employees can receive support with ongoing training and development tailored to their unique needs and career goals. By providing accessible, on-demand learning, it empowers workers to upskill and grow within their roles, fostering a sense of progress and fulfillment. These resources are essential for Gen-Z, who prioritize personal growth and are likelier to stay with employers who invest in their development.

As we look toward the future, it’s clear that AI is not just a tool for corporate jobs but also a powerful ally for the hourly workforce. By embracing AI, businesses can meet diverse employee needs, enhance productivity and create work environments that are technologically advanced and genuinely supportive. However, for AI to reach its potential in workplaces, industry-wide standards around data transparency and ethical practices are essential.