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Immunotherapy has rapidly advanced the field of medicine and has saved countless lives. The approach is much different than using an external chemical, such as in the case of chemotherapy. Immunotherapy leverages the body’s own immune system to recognize and attack foreign pathogens, specifically cancer. While there are many versions of immunotherapy, one rising star among them is known as Chimeric Antigen Receptor (CAR) T cell therapy. This therapy (usually) takes a patient’s own cells in the blood to generate engineered immune or T cells to fight the tumor. T cells are a critical immune cell population responsible for killing or lysing infected cells. In the case of CAR T cell therapy, the T cells from the patient are engineered to recognize receptors on the tumor. The CAR T-cells are then triggered to release different proteins and lyse the tumor cells. This type of therapy has revolutionized the way we treat patients with hematopoietic malignancies or blood cancers.

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CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections. However, an article published in the journal Cell Reports shows that an imbalance in the volumes of these defense cells in different parts of the lung in response to infection can do more harm than good.

The study described in the article involved infecting mice with hypervirulent tuberculosis and influenza. The authors concluded that an “ideal amount” of CD4+ T cells in the lungs was required for a cure.

This finding opens up perspectives for therapeutic interventions aimed at combating diseases that attack the lungs while not affecting the ability of the adaptive immune system to fight off infection. Even relatively small numbers of CD4+ T cells in the lungs proved sufficient to afford protection against tuberculosis, for example.

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One of the country’s best-known science museums, San Francisco’s Exploratorium, is located less than three miles north of Gladstone Institutes—proximity that has resulted in creative, high-science collaborations like the permanent exhibit featured in the latest issue of Stem Cell Reports.

Among the museum’s most popular exhibits, “Give Heart Cells A Beat” opens a rare window into the microscopic world of the beating human heart, using technology and materials made possible through Gladstone’s science and expertise. With the exhibit, the team created the first interactive museum experience that allows the public to interact directly with living cardiomyocytes.

“It’s like having a lens into yourself because these same types of cells are within us—it’s an incredible experience for our visitors,” says Kristina Yu, Ph.D., senior director of science R&D for the Exploratorium.

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Britain’s largest telecom service provider has put forward a plan to ensure that EVs are always within range of a charger. To do that, they’re planning to retrofit their existing street cabinets into publicly accessible L2 chargers.

Retrofitting a city’s existing electronic and digital infrastructure to promote widespread adoption of EVs isn’t a new idea — but UK telecom giant BT Group isn’t content to just talk about what’s possible. They’ve already done it!

The first such telecom cabinet-to-L2 charger conversion has already been completed in East Lothian, Scotland, and BT Group isn’t stopping there. The company says it plans to convert more cabinets in Scotland, England, Wales, and Northern Ireland in the coming months, with as many as 600 such conversions earmarked for completion by the end of 2024.

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I’m excited to share my latest Opinion article on AI at The Hill, a top political site/paper read by the White House and Congress:

Regardless what politicians promise, this age of AI and robots will also affect the size and growth rates of the U.S. government. Federal and state government may not immediately take up with automation and AI to the extent the private sector does, but eventually the stark rationality of lower overhead expenses—and thus lower taxes for citizens—will prevail.

This is a good thing. A smaller, nimble, more efficient government will benefit the majority of people.

Zoltan Istvan writes and speaks on transhumanism, artificial intelligence, and the future. He is the author of “The Transhumanist Wager,” and is the subject of the forthcoming biography by Dr. Ben Murnane and Changemakers Books titled, “Transhuman Citizen: Zoltan Istvan’s Hunt for Immortality.”

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To create the breakthrough model, researchers integrated two cutting-edge #AI techniques for the first time in the fields of #bioinformatics and #Cheminformatics : the well-known “Encoder-Decoder Transformer architecture” and “Reinforcement Learning via Monte Carlo Tree Search” (RL-MCTS).

Generative artificial intelligence platforms, from ChatGPT to Midjourney, grabbed headlines in 2023. But GenAI can do more than create collaged images and help write emails—it can also design new drugs to treat disease.

Today, scientists use advanced technology to design new synthetic drug compounds with the right properties and characteristics, also known as “de novo drug design.” However, current methods can be labor-, time-, and cost-intensive.

Inspired by ChatGPT’s popularity and wondering if this approach could speed up the drug design process, scientists in the Schmid College of Science and Technology at Chapman University in Orange, California, decided to create their own GenAI model, detailed in a new paper, “De Novo Drug Design using Transformer-based Machine Translation and Reinforcement Learning of Adaptive Monte-Carlo Tree Search,” appearing in the journal Pharmaceuticals.

Continue reading “Scientists code ChatGPT to design new medicine” | >

Two astrophysicists from the Laboratory for Space Research (LSR) at the University of Hong Kong (HKU) have finally solved a 20-year-old astrophysical puzzle concerning the lower-than-expected amounts of the element sulfur found in planetary nebulae (PNe) in comparison to expectations and measurements of other elements and other types of astrophysical objects.

The expected levels of have long appeared to be “missing in action.” However, they have now finally reported for duty after hiding in plain sight, as a result of leveraging highly accurate and reliable data. The team has recently reported their findings in The Astrophysical Journal Letters.

PNe are the short-lived glowing, ejected, gaseous shrouds of dying stars that have long fascinated and enthused professional and amateur astronomers alike with their colorful and varied shapes. PNe live for only a few tens of thousands of years compared to their host stars, which can take billions of years before they pass through the PN phase on the way to becoming white dwarfs.

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