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May 28, 2023

A potential cure for diabetes found in human stomach cells

Posted by in category: biotech/medical

The ability to acquire gut stem cells via biopsy and have a significant proliferative capacity in culture make them an invaluable resource for autologous cell treatments. In the mouse gut, insulin-producing cells can be produced. Still, human gut tissues have not been able to produce an abundance or durability of insulin-secreting cells to assess their potential as a cell treatment for diabetes.

In a new study, scientists from Weill Cornell Medicine showed that stem cells from human stomach can be converted into insulin-secreting cells. Scientists demonstrated that they could obtain the stem cells from the human stomach and reprogram them directly—with strikingly high efficiency—into cells that closely resemble pancreatic insulin-secreting cells known as beta cells.

In experiments on a mouse model, this approach reversed disease signs. According to scientists, the study offers a promising approach, based on patient’s cells, for type 1 diabetes and severe type 2 diabetes.

May 28, 2023

Stephen Hawking’s last collaborator on physicist’s final theory

Posted by in category: space

When Thomas Hertog was first summoned to Stephen Hawking’s office in the late 1990s, there was an instant connection between the young Belgian researcher and the legendary British theoretical physicist.

“Something clicked between us,” Hertog said.

That connection would continue even as Hawking’s debilitating disease ALS robbed him of his last ways to communicate, allowing the pair to complete a new that aims to turn how science looks at the on its head.

May 28, 2023

Exclusive: Chandrayaan-3 spacecraft arrives at India’s spaceport in preparation for July launch

Posted by in categories: satellites, security

The spacecraft that the Indian Space Research Organization (ISRO) hopes to land on the moon later this year, has been wheeled into the country’s spaceport, Satish Dhawan Space Centre, WION has learnt.

Named as Chandrayaan-3 (Sanskrit for Moon Vehicle-3), this will be India’s third lunar mission and will attempt both controlled soft-landing on the lunar surface and in-situ analysis by the means of a rover.

In the evening hours on Friday, the slow-moving, specialised truck ferrying the spacecraft from UR Rao Satellite Centre in Bengaluru arrived at India’s spaceport, under a security blanket.

May 28, 2023

Wendy’s Automates Drive-Thru With Google’s Order-Taking AI Chatbot

Posted by in category: robotics/AI

The chain says it’s trying to speed up the drive-thru to squeeze in a few extra sales each day.

May 28, 2023

Researchers develop calcium metal battery with long cycle life

Posted by in categories: energy, materials

As potential alternatives to lithium-ion batteries, rechargeable calcium (Ca) metal batteries offer advantageous features such as high energy density, cost-effectiveness, and natural elemental abundance. Its properties are also thought to help accelerate ion transport and diffusion in electrolytes and cathode materials, giving it an edge over other lithium-ion battery alternatives such as magnesium and zinc.

However, many challenges impede the development of practical Ca metal batteries. The challenges include the lack of an efficient electrolyte and the absence of cathode materials with sufficient Ca2+ storage capabilities.

Now, Tohoku University researchers have developed a prototype calcium metal rechargeable battery capable of 500 cycles of repeated charge-discharge – the benchmark for practical use.

May 28, 2023

Scientists create matter from nothing in groundbreaking experiment

Posted by in categories: cosmology, particle physics, quantum physics

We’ve probably all heard the phrase you can’t make something from nothing. But in reality, the physics of our universe isn’t that cut and dry. In fact, scientists have spent decades trying to force matter from absolutely nothing. And now, they’ve managed to prove that a theory first shared 70 years ago was correct, and we really can create matter out of absolutely nothing.

The universe is made up of several conservation laws. These laws govern energy, charge, momentum, and so on down the list. In the quest to fully understand these laws, scientists have spent decades trying to figure out how to create matter – a feat that is far more complex than it even sounds. We’ve previously turned matter invisible, but creating it out of nothing is another thing altogether.

There are many theories on how to create matter from nothing – especially as quantum physicists have tried to better understand the Big Bang and what could have caused it. We know that colliding two particles in empty space can sometimes cause additional particles to emerge. There are even theories that a strong enough electromagnetic field could create matter and antimatter out of nothing itself.

May 27, 2023

Charismatic Robot Voices: A Boost for Team Creativity?

Posted by in categories: innovation, robotics/AI

Summary: Robotic voices with a charismatic tone can positively influence the creative performance of teams.

Researchers designed a social robot’s speech to sound charismatic, employing a confident, passionate tone and tested its effects on students during a creativity task.

The results revealed students were more innovative when the robot used a charismatic tone, leading to more original and elaborate ideas.

May 27, 2023

Psychedelic substance 5-MeO-DMT induces long-lasting neural plasticity in mice

Posted by in categories: biotech/medical, engineering, neuroscience

The psychedelic substances 5-MeO-DMT causes a long-lasting increase in the number of tiny protrusions called dendritic spines in the brain, according to new research published in Neuropsychopharmacology. The study, which was conducted on mice, sheds light on the behavioral and neural mechanisms of 5-MeO-DMT.

Serotonergic psychedelics (such as psilocybin and LSD) have shown promise as potential therapeutics for mental illnesses like depression and anxiety. Short-acting compounds are particularly interesting because they require less dosing time, which could improve patient access to treatment. In humans, 5-MeO-DMT produces a short-lasting experience due to its rapid breakdown in the body.

“My lab started research on psychiatric drugs like ketamine and psychedelics about 10 years ago. We were motivated by how basic science and clinical research can together powerfully move a drug forward to become medicine. Specifically I believe there is a lot of potential for psychedelics as therapeutics, and that drives our interest in this topic,” said study author Alex Kwan (@kwanalexc), an associate professor in the Meinig School of Biomedical Engineering at Cornell University.

May 27, 2023

AI Can Help You Ask Better Questions — and Solve Bigger Problems

Posted by in categories: business, robotics/AI

Most companies still view AI rather narrowly, as a tool that alleviates the costs and inefficiencies of repetitive human labor and increasing organizations’ capacity to produce, process, and analyze piles and piles of data. But when paired with “soft” inquiry-related skills it can help people ask better questions and be more innovative.

There are two distinct, yet related, paths to do this. 1) Use the technology to change the cadence and patterns of their questions: AI increases question velocity, question variety, and question novelty. 2) Use AI to transform the conditions and settings where people work so that questions that spark change — what we call “catalytic” questions — can emerge. This pushes leaders out of their comfort zones and into the position of being intellectually wrong, emotionally uncomfortable, and behaviorally quiet and more reflective, all of which, it turns out, promotes innovative thinking and action.

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May 27, 2023

Gene Editing Gets a Triple Boost: “Happy Accident” Leads to Enhanced CRISPR Efficiency

Posted by in categories: bioengineering, biotech/medical, genetics

Scientists have enhanced the efficiency of CRISPR/Cas9 gene editing by threefold using interstrand crosslinks, without resorting to viral material for delivery. This approach boosts the cell’s natural repair mechanisms, allowing for more accurate and efficient gene editing, potentially improving disease research and preclinical work.

Gene editing is a powerful method for both research and therapy. Since the advent of the Nobel Prize-winning CRISPR/Cas9 technology, a quick and accurate tool for genome editing discovered in 2012, scientists have been working to explore its capabilities and boost its performance.

Researchers in the University of California, Santa Barbara biologist Chris Richardson’s lab have added to that growing toolbox, with a method that increases the efficiency of CRISPR/Cas9 editing without the use of viral material to deliver the genetic template used to edit the target genetic sequence. According to their new paper published in the journal Nature Biotechnology, their method stimulates homology-directed repair (a step in the gene editing process) by approximately threefold “without increasing mutation frequencies or altering end-joining repair outcomes.”