Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 1944

Editor’s note: This story is part of Meet a UChicagoan, a regular series focusing on the people who make UChicago a distinct intellectual community. Read about the others here.

Wide is the spectrum of scientific inquiry, ranging from the philosophical— What is information?—to the banal — Where did I put that Allen wrench?

For University of Chicago graduate student Chloe Washabaugh, there is joy to be found in all of it. A Ph.D. student in quantum engineering at the Pritzker School of Molecular Engineering, Washabaugh fashions molecules into tiny quantum information processors, designing them to sense, send or store data—whatever the need.

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Scientists have dedicated their lives to finding a cure for cancer. America became a science hub for cancer research, particularly after President Richard Nixon declared the “war on cancer” in 1971. As a result, extensive research has been published on how cancer functions and different ways to target both solid and hematologic malignancies. Unfortunately, there is currently not a cure for cancer. Although some patients are treated and enter remission, tumors can reoccur. In addition, some tumor types are harder to treat than others. Although the science community is hopeful to effectively treat each type of cancer, more work is needed to discern why some tumors are harder to treat than others.

Many tumors evade the immune system through different mechanisms and mutations. Therapy-resistant cells may stay dormant for a period of time before proliferating, which results in cancer recurrence. Additionally, different surface markers prevent immune cell activation which target cancer. This allows the tumor to proliferate without an immune cell response. Many different immunotherapies being developed target these surface markers to activate T cells, which kill or lyse infections. The type of immunotherapy that refers to the blockade of cell-to-cell interactions is known as checkpoint inhibitors. Checkpoint proteins are surface markers that help the immune cell differentiate from self. More specifically, these cells provide a signal for immune cells to avoid lysing healthy cells and protect from autoimmunity. However, tumors use a selection of checkpoint proteins to avoid immune cell detection.

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Fungal infections have been slipping past their usual geographic boundaries and increasing in hospitals and other settings — and, as Scientific American’s Maryn McKenna has pointed out, we currently don’t have much recourse against them.

Fungal infections are incredibly hard to beat, even with modern medicine.

But MIT researchers studying the common yeast Candida albicans may have found a new effective antifungal candidate, and you’ve got some in you right now: mucus.

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Tardigrades are often considered the most endearing invertebrates, akin to the capybara of their realm, yet their significance surpasses mere charm.

This year, researchers from Harvard Medical School, the University of North Carolina at Chapel Hill, and Marshall University in Huntington, West Virginia, discovered that when the tardigrades are under stress, their bodies produce unstable free radicals of oxygen and an unpaired electron.

When the amino acid cysteine, which is used in protein production, comes into contact with these oxygen-free radicals, it becomes oxidized, triggering a signal that tells the tardigrade when it’s time to enter into the tun. When the researchers prevented the free radicals from reacting with cysteine, the tardigrades couldn’t enter tun, meaning the cysteine is likely a key to all tardigrades’ survival strategies.

Continue reading “Beyond cute: What tardigrades can teach us about life and death” | >

Ferromagnetism and antiferromagnetism have long been known to scientists as two classes of magnetic order of materials. Back in 2019, researchers at Johannes Gutenberg University Mainz (JGU) postulated a third class of magnetism, called altermagnetism. This altermagnetism has been the subject of heated debate among experts ever since, with some expressing doubts about its existence.

Recently, a team of experimental researchers led by Professor Hans-Joachim Elmers at JGU was able to measure for the first time at DESY (Deutsches Elektronen-Synchrotron) an effect that is considered to be a signature of altermagnetism, thus providing evidence for the existence of this third type of magnetism. The research results were published in Science Advances.

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Independent of the smart-corridor project, two major companies behind self-driving big rig technology told KXAN they plan to remove safety drivers and go completely driverless by the end of the year.

A spokesperson for the California-based company Kodiak Robotics told KXAN it started operating self-driving big rigs on routes around Texas in 2019, always with backup safety drivers.

In that time, “the bulk of Kodiak’s deliveries have been between our Dallas operations hub and Houston, Austin, San Antonio, Oklahoma City, and Atlanta,” Kodiak spokesman Daniel Goff said.

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