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While Pika’s AI generated videos remain arguably lower quality and less “realistic” than the ones shown off by OpenAI’s Sora or even another rival AI video generation startup, Runway, the addition of the new Lip Sync feature puts it ahead of both in offering capabilities disruptive to traditional filmmaking software.

With Lip Sync, Pika is addressing one of the last remaining barriers to AI being useful for creating longer narrative films. Most other leading AI video generators don’t yet currently offer a similar feature natively.

Instead, in order to add spoken dialog and matching lip movements to characters inside the AI video, users have had to make do with third party tools and cumbersome additions in post production, which give the resulting video of a “low budget,” Monty Python-esque quality.

We conducted a multicenter, nested case–control study of Alzheimer’s disease biomarkers in cognitively normal participants who were enrolled in the China Cognition and Aging Study from January 2000 through December 2020. A subgroup of these participants underwent testing of cerebrospinal fluid (CSF), cognitive assessments, and brain imaging at 2-year–to–3-year intervals. A total of 648 participants in whom Alzheimer’s disease developed were matched with 648 participants who had normal cognition, and the temporal trajectories of CSF biochemical marker concentrations, cognitive testing, and imaging were analyzed in the two groups.

The median follow-up was 19.9 years (interquartile range, 19.5 to 20.2). CSF and imaging biomarkers in the Alzheimer’s disease group diverged from those in the cognitively normal group at the following estimated number of years before diagnosis: amyloid-beta (Aβ)42, 18 years; the ratio of Aβ42 to Aβ40, 14 years; phosphorylated tau 181, 11 years; total tau, 10 years; neurofilament light chain, 9 years; hippocampal volume, 8 years; and cognitive decline, 6 years. As cognitive impairment progressed, the changes in CSF biomarker levels in the Alzheimer’s disease group initially accelerated and then slowed.

In this study involving Chinese participants during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease, we observed the time courses of CSF biomarkers, the times before diagnosis at which they diverged from the biomarkers from a matched group of participants who remained cognitively normal, and the temporal order in which the biomarkers became abnormal. (Funded by the Key Project of the National Natural Science Foundation of China and others; ClinicalTrials.gov number, NCT03653156. opens in new tab.)

Joe Louca: “Think of it like a realistic video game set on the Moon – we want to make sure the virtual version of moon dust behaves just like the actual thing, so that if we are using it to control a robot on the Moon, then it will behave as we expect.”


After Neil Armstrong took his first steps on the Moon, he said, “It’s almost like a powder”, as he described the lunar regolith, and astronauts on future Apollo missions found working on the lunar surface rather cumbersome and tedious due to the much finer lunar dust compared to Earth’s dirt. Therefore, what steps can be taken to better prepare future rovers and astronauts for NASA’s Artemis program to work on the lunar surface?

This is what a recent study published in Frontiers in Space Technologies hopes to address as a team of researchers led by the University of Bristol developed virtual models of lunar regolith simulants that could provide cost-effective methods to prepare astronauts and robots to work on the lunar surface, someday.

This study builds on an August 2023 study conducted by these same team members that explored the trust between teleoperated robots operating at long distances from Earth with their human controllers. The team found that the human controllers desired to train on increasing difficulty for operating their robots before working the real thing.