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Bioengineers apply engineering and design principles to develop innovative solutions for biological and medical problems. Our researchers are creating tools and technologies to eliminate bottlenecks and reduce the time it takes for discoveries in stem cell research to reach the clinic as life-saving therapies. This includes everything from creating biodegradable scaffolds that can help stem cells Cells that have the ability to differentiate into multiple types of cells and make an unlimited number of copies of themselves. stem cells Cells that have the ability to differentiate into multiple types of cells and make an unlimited number of copies of themselves. regenerate damaged tissue to engineering materials that can make the immune-boosting effects of vaccines last longer.

Nanotechnology is the field of science focused on creating and manipulating structures and materials at the nanometer scale (one billionth of a meter). The application of nanotechnology in medicine recreates the natural scale of biological phenomena, enabling more precise and less invasive approaches for preventing, diagnosing and treating disease. Together with scientists from the California NanoSystems Institute at UCLA, our researchers are creating nanomaterials that enable targeted drug and gene delivery, more efficient production of cells for use as therapies and better models of human disease. Because nanotechnology-based methods enhance efficiency, require less material and use up less space, they can offer low cost, high-accuracy solutions for the study, diagnosis and treatment of disease.

By leveraging the combined strengths of nanotechnology and bioengineering, our researchers are accelerating the development of more effective and affordable stem cell-based therapies for a host of intractable medical conditions.

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A new stroke-healing gel created by UCLA researchers helped regrow neurons and blood vessels in mice whose brains had been damaged by strokes. The finding is reported May 21 in Nature Materials.

“We tested this in laboratory mice to determine if it would repair the brain and lead to recovery in a model of stroke,” said Dr. S. Thomas Carmichael, professor of neurology at the David Geffen School of Medicine at UCLA and co-director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. “The study indicated that new brain tissue can be regenerated in what was previously just an inactive brain scar after stroke.”

The results suggest that such an approach could some day be used to treat people who have had a stroke, said Tatiana Segura, a former professor of chemical and biomolecular engineering at UCLA who collaborated on the research. Segura is now a professor at Duke University.

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Brain cells receive sensory inputs from the outside world and send signals throughout the body telling organs and muscles what to do. Although neurons comprise only 10% of brain cells, their functional and genomic integrity must be maintained over a lifetime. Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication.

Neurons, however, do not divide. For this reason, they are at greater risk of accumulating damage and must develop alternative repair pathways to avoid dysfunction. Scientists do not understand how neuronal DNA damage is controlled in the absence of replication checkpoints.

A recent study led by Cynthia McMurray and Aris Polyzos in Lawrence Berkeley National Laboratory’s (Berkeley Lab’s) Molecular Biophysics and Integrated Bioimaging Division addressed this knowledge gap, shedding light on how DNA damage and repair occur in the brain. Their results suggest that DNA damage itself serves as the checkpoint, limiting the accumulation of genomic errors in cells during natural aging.

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This video provides a progress update on cutting-edge research exploring epigenetic reprogramming and small molecule cocktails for cellular rejuvenation.

Dr David Sinclair delve into the latest studies on how these approaches can potentially reverse the effects of aging at the cellular level. Topics covered include:

• The mechanisms of epigenetic reprogramming using Yamanaka factors. The development and testing of novel small molecule cocktails. Applications in various tissues and organs Research on reversing cellular senescence and restoring cell identity. The use of AI for high-throughput screening of potential rejuvenating compounds.
This update highlights recent advancements, challenges, and future directions in this exciting field of research.

* Credits to ARRD \& Dr David Sinclair*

Please note that the links below are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support!
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A serious knock to the head may also deliver an insidious blow to the human immune system – a one-two punch that could reawaken dormant viruses in the body, potentially contributing to neurodegenerative disease.

A study using stem cell ‘mini brains’ has shown that a herpes simplex virus 1 (HSV-1) infection already ‘arrested’ by the immune system can shake off its shackles when brain tissue is injured.

“We thought, what would happen if we subjected the brain tissue model to a physical disruption, something akin to a concussion?” says biomedical engineer Dana Cairns from Tufts University in the US.

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What if a distant planet held the key to finding life beyond Earth? NASA’s discovery has scientists buzzing with curiosity.

This revelation might bring us closer to answering one of humanity’s biggest questions: Are we truly alone in the universe?

Over the years, NASA has had its share of controversies, from concealed data to accusations of manipulating the truth. Yet, amidst the whirlwind of skepticism, the space agency occasionally unveils findings that could potentially reshape our understanding of the cosmos and our place within it. NASA has recently spotlighted a super-Earth larger than our own, with an atmosphere containing a gas typically only associated with life. This discovery invites a torrent of questions and possibilities. What does this mean for our understanding of life beyond Earth?

K2-18 b, an exoplanet that continues to captivate astronomers and scientists alike, is redefining our understanding of the cosmos. Situated 120 light-years away in the constellation Leo, this remarkable planet orbits a cool, red dwarf star named K2-18 within the star’s habitable zone. Its discovery was made possible by NASA’s James Webb Space Telescope (JWST), which observed K2-18 b as it transited in front of its host star, allowing scientists to analyze the starlight passing through the exoplanet’s atmosphere.

This Super-Earth is approximately 8.6 times the mass of our planet and 2.6 times its radius, placing it in a class of planets known as sub-Neptunes, which are more massive than Earth but smaller than Neptune. Unlike anything in our solar system, these planets present a unique challenge for study due to their diverse and complex atmospheres.

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Can artificial intelligence decode the secrets of life itself? Scientists are working on creating virtual cells that behave like real ones, potentially transforming medical research. But is this groundbreaking vision closer to reality—or still a distant dream?

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Even so, many wonder: If the universe is at bottom deterministic (via stable laws of physics), how do these quantum-like phenomena arise, and could they show up in something as large and complex as the human brain?

Quantum-Prime Computing is a new theoretical framework offering a surprising twist: it posits that prime numbers — often celebrated as the “building blocks” of integers — can give rise to “quantum-like” behavior in a purely mathematical or classical environment. The kicker? This might not only shift how we view computation but also hint at new ways to understand the brain and the nature of consciousness.

Below, we explore why prime numbers are so special, how they can host quantum-like states, and what that might mean for free will, consciousness, and the future of computational science.

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