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Low-oxygen air slows Parkinson’s progression and restores movement in mice

Researchers from the Broad Institute and Mass General Brigham have shown that a low-oxygen environment—similar to the thin air found at Mount Everest base camp—can protect the brain and restore movement in mice with Parkinson’s-like disease.

The new research, in Nature Neuroscience, suggests that cellular dysfunction in Parkinson’s leads to the accumulation of excess oxygen molecules in the brain, which then fuel neurodegeneration—and that reducing could help prevent or even reverse Parkinson’s symptoms.

“The fact that we actually saw some reversal of neurological damage is really exciting,” said co-senior author Vamsi Mootha, an institute member at the Broad, professor of systems biology and medicine at Harvard Medical School, and a Howard Hughes Medical Institute investigator in the Department of Molecular Biology at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system.

Beyond words: Study maps the cognitive force of metaphor

Metaphors are a fundamental aspect of human language and cognition, allowing us to understand complex concepts and relationships by mapping them onto more familiar and concrete domains. However, the nature of metaphors and how they work is still not well understood.

In a new paper published in PLOS Complex Systems, Max-Planck-Institute for Mathematics in the Sciences researchers Marie Teich and Wilmer Leal together with director Jürgen Jost have developed a formal framework and large-scale empirical methodology to analyze metaphors and their role in conceptual theory.

The study confirms the fundamental assumption in conceptual metaphor theory that metaphors are enduring linguistic and cognitive structures, not merely rhetorical figures. Using complex systems tools, the researchers identified a metaphor network with distinctions between abstract and concrete categories, and two significant metaphorical processes: mappings from concrete to abstract topics and the emergence of new mappings between concrete domains.

Ultra-short RNA insertions offer scalable, cost-effective gene silencing for agriculture

A team of researchers from the Spanish National Research Council has made a significant advance in plant biotechnology by developing a new method for silencing genes. The novel technique uses ultra-short ribonucleic acid (RNA) sequences carried by genetically modified viruses to achieve genetic silencing, allowing the customization of plant traits. The work, published in the Plant Biotechnology Journal, opens up new avenues for crop improvement, functional genomics, and sustainable agriculture.

Viral vector technology involves modifying viruses, removing the genetic material that causes disease, to turn them into vehicles that carry the RNA sequence to be introduced into an organism. This technique, when applied to plants, has already proven effective under experimental conditions in inducing flowering and accelerating the development of improved crop varieties, modifying plant architecture to facilitate adaptation to mechanization, improving drought tolerance, and producing metabolites beneficial to human health, among other applications.

Now, the method developed by the CSIC, together with the Valencian University Institute for Research on the Conservation and Improvement of Agrodiversity (COMAV) and the Italian Department of Applications and Innovation in Supercomputing (Cineca), represents an optimization of technological platforms to accelerate the development and validation of agricultural applications based on viral vectors.

Friction that cools: Threshold effects enable self-stopping robot swarms

How can a horde of active robots be automatically brought to a standstill? By arresting their dynamics in a self-sustained way. This phenomenon was discovered by physicists at Heinrich Heine University Dusseldorf (HHU) and La Sapienza University in Rome. The threshold principle of static friction with the ground plays a decisive role here: it removes the kinetic energy of two robots after a mutual collision so efficiently that they can no longer set themselves in motion.

The researchers describe in the journal Nature Communications that this fundamental effect can also be used to construct controllable moving systems.

Friction creates heat, as anyone knows who has rubbed their hands together in winter weather. And costs energy. Road friction on vehicle tires, for example, will cause a moving car to steadily slow down unless the accelerator is used.

Scientists achieve direct measurement of quantum metric tensor in black phosphorus

Quantum distance refers to a measure of quantum mechanical similarity between two quantum states. A quantum distance of one means that the two quantum states are the same, whereas a quantum distance of zero implies that they are exactly the opposite. Physicists introduced this concept in the realm of theoretical science a long time ago, but its importance has been increasingly recognized in the field of physics only in recent times.

In the last few years, many have tried to measure the quantum distance of electrons in real , but a direct measurement of the quantum distance and thus quantum metric tensor—a key geometric quantity in modern physics defined in terms of the distance between nearby quantum states—has remained elusive so far.

Since the quantum metric tensor is highly relevant in explaining and understanding fundamental physical phenomena in solids, it is, therefore, crucial to come up with an effective methodology for its direct measurement in solid-state systems.

Ultrafast light switch achieved with asymmetric silicon metasurfaces in nanophotonics

In nanophotonics, tiny structures are used to control light at the nanoscale and render it useful for technological applications. A key element here is optical resonators, which trap and amplify light of a certain color (wavelength).

Previous methods of controlling these resonances were more like a dimmer switch: You could weaken the resonance or slightly shift its color. However, genuine on-and-off switching was not possible, as the resonators always remain fundamentally coupled with the light.

A team led by Andreas Tittl, Professor of Experimental Physics at LMU, has now precisely achieved this breakthrough, together with partners from Monash University in Australia. As the researchers report in the journal Nature, they have developed a new method for controlling the coupling between nanoresonators and light in a targeted manner on ultrafast timescales. In this way, a resonance can be created from nothing within a few picoseconds or made to vanish completely again.

Newly derived optical formula shines a light on organic crystal altermagnet candidate

Researchers have uncovered the magnetic properties and underlying mechanisms of a novel magnet using advanced optical techniques. Their study focused on an organic crystal believed to be a promising candidate for an “altermagnet”—a recently proposed third class of magnetic materials. Unlike conventional ferromagnets and antiferromagnets, altermagnets exhibit unique magnetic behavior.

“Unlike typical magnets that attract each other, altermagnets do not exhibit net magnetization, yet they can still influence the polarization of reflected light,” points out Satoshi Iguchi, associate professor at Tohoku University’s Institute for Materials Research. “This makes them difficult to study using conventional optical techniques.”

To overcome this, Iguchi and his colleagues applied a newly derived general formula for light reflection to the organic crystal, successfully clarifying its and origin. The work is published in the journal Physical Review Research.

A dual ion beam tests new steel under fusion energy-producing conditions

A new class of advanced steels needs more fine-tuning before use in system components for fusion energy—a more sustainable alternative to fission that combines two light atoms rather than splitting one heavy atom. The alloy, a type of reduced activation ferritic/martensitic or RAFM steel, contains billions of nanoscale particles of titanium carbide meant to absorb radiation and trap helium produced by fusion within a single component.

When subjected to and concentrations representative of fusion, the titanium-carbide precipitates initially helped trap helium but later dissolved under high damage levels. After dissolving, the alloy swelled as it was no longer able to disperse and trap helium, which could compromise system components.

The first-of-its-kind systematic investigation led by University of Michigan engineers was published in Acta Materialia and the Journal of Nuclear Materials in a series of three papers.

Scientists Were Wrong: Apollo 16 Rocks Rewrite the Story of the Moon’s Exosphere

The Moon’s surface is constantly exposed to the solar wind, a stream of charged particles emitted by the Sun. These energetic ions can dislodge atoms from the Moon’s outermost rocky layer, contributing to the formation of a very sparse layer of gas around the Moon known as the exosphere. However, the exact mechanism behind the creation of this exosphere has remained unclear.

Researchers at TU Wien, working with international collaborators, have now shown that a major contributing process, sputtering caused by the solar wind, has been greatly overestimated in earlier studies. This discrepancy stems from previous models overlooking the Moon’s actual surface texture, which is rough and porous.

For the first time, the team used original Apollo 16 samples in high-precision laboratory experiments, along with advanced 3D modeling, to calculate more accurate sputtering rates. Their findings are published in Communications Earth & Environment.

Cheaper, Stronger Titanium? New 3D-Printing Breakthrough Makes It Possible

Researchers at RMIT University in Australia have developed a new form of titanium for 3D printing that costs approximately 33% less than the titanium alloys currently in widespread use.

Replacing expensive elements

The researchers substituted vanadium, which has become increasingly costly, with more affordable and widely available alternative elements.

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