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Biomarker for Parkinson’s disease using single extracellular vesicle detection assay.

Detecting minute amounts of neuronally derived biomarkers in the massive protein excess of easily accessible biofluids such as blood is challenging.

The researchers develop a droplet-based microfluidic immunoassay for multiplexed quantification of membrane associated proteins at single extracellular-vesicle (EV) resolution.

They identify membrane-associated a-synuclein on the surface of neuronal EVs and demonstrate that it is increased under pathological conditions and in individuals at risk of or with Parkinson’s disease. https://sciencemission.com/Single-extracellular-vesicle-detection-assay

Yan et al. develop a droplet-based microfluidic immunoassay for multiplexed quantification of membrane-associated proteins at single-extracellular-vesicle (EV) resolution. They identify membrane-associated α-synuclein on the surface of neuronal EVs and demonstrate that it is increased under pathological conditions and in individuals at risk of or with Parkinson’s disease.

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🚀 Imagine a future where living to 150 is possible—but only if you give up sugar, take ice-cold showers, and inject custom-engineered bacteria. Would you do it? In this deep dive into longevity science, we uncover the shocking truth about genetics, lifestyle, biohacking, and whether living longer actually makes life better. Plus, the real reason happiness might be the ultimate anti-aging hack! 🤯💡

#Longevity #AntiAging #Biohacking #LiveLonger #Science #Health #Wellness #LongevitySecrets #HealthyAging #LifeExtension

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Cases of the fungal infection Candida auris are rising rapidly and coming from more sources too, a new US study reveals.

C. auris was first reported in the US in 2016 and is considered an “urgent antimicrobial resistance threat” in hospitals, according to the Centers for Disease Control and Prevention (CDC).

Focusing on a large health system in Miami, Florida, the new research found that reported clinical cases had risen from 5 in 2019 to 115 in 2023 – a considerable jump of 2,200 percent in four years.

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Biological systems, once thought too chaotic for quantum effects, may be quietly leveraging quantum mechanics to process information faster than anything man-made.

New research suggests this isn’t just happening in brains, but across all life, including bacteria and plants.

Schrödinger’s legacy inspires a quantum leap.

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Researchers have discovered an unexpected superconducting transition in extremely thin films of niobium diselenide (NbSe2). Publishing in Nature Communications, they found that when these films become thinner than six atomic layers, superconductivity no longer spreads evenly throughout the material, but instead becomes confined to its surface.

This discovery challenges previous assumptions and could have important implications for understanding and developing advanced quantum technologies.

Researchers at the Hebrew University of Jerusalem have made a surprising discovery about how superconductivity behaves in extremely thin materials. Superconductors are materials that allow electric current to flow without resistance, which makes them incredibly valuable for technology. Usually, the properties of superconductors change predictably when the materials become thinner; however, this study found something unexpected.

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