Discover how a patched Microsoft 365 Copilot vulnerability could have led to data theft using ASCII smuggling and prompt injection techniques.
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Proof-of-concept study demonstrates mid-infrared computational temporal ghost imaging
Ghost imaging in the time domain allows for reconstructing fast temporal objects using a slow photodetector. The technique involves correlating random or pre-programmed probing temporal intensity patterns with the integrated signal measured after modulation by the temporal object. However, the implementation of temporal ghost imaging necessitates ultrafast detectors or modulators for measuring or pre-programming the probing intensity patterns, which are not available in all spectral regions especially in the mid-infrared region.
Study proposes generalized approach to light-matter interactions
A study coordinated by the University of Trento with the University of Chicago proposes a generalized approach to the interactions between electrons and light. In the future, it may contribute to the development of quantum technologies as well as to the discovery of new states of matter. The study is published in Physical Review Letters.
Superconductivity study confirms existence of edge supercurrents
Topological materials are materials that have unusual properties that arise because their wavefunction—the physical law guiding the electrons—is knotted or twisted. Where the topological material meets the surrounding space, the wavefunction must unwind. To accommodate this abrupt change, the electrons at the edge of the material must behave differently than they do in the main bulk of the material.
Covalently linked adenovirus-AAV complexes as a novel platform technology for gene therapy
Adeno-associated virus (AAV) has found immense success as a delivery system for gene therapy, yet the small 4.7 kb packaging capacity of the AAV sharply limits the scope of its application. In addition, high doses of AAV are frequently required to facilitate therapeutic effects, leading to acute toxicity issues. While dual and triple AAV approaches have been developed to mitigate the packaging capacity problem, these necessitate even higher doses to ensure that co-infection occurs at sufficient frequency. To address these challenges, we herein describe a novel delivery system consisting of adenovirus (Ad) covalently linked to multiple adeno-associated virus (AAV) capsids as a new way of more efficiently co-infecting cells with lower overall amounts of AAVs. We utilize the DogTag-DogCatcher (DgT-DgC) molecular glue system to construct our AdAAVs and we demonstrate that these hybrid virus complexes achieve enhanced co-transduction of cultured cells. This technology may eventually broaden the utility of AAV gene delivery by providing an alternative to dual or triple AAV which can be employed at lower dose while reaching higher co-transduction efficiency.
Although adeno-associated virus (AAV) gene therapy has shown enormous promise and led to five clinically approved treatments,1–3 it is consistently hampered by the vector’s low DNA packaging capacity of 4.7 kb. Great effort has gone into developing dual AAV systems, which deliver two parts of a therapeutic gene in separate capsids that aim to co-infect the same cells.4–7 Analogous triple AAV systems have also been explored.8,9 Dual and triple AAV systems can recombine their split genes into complete form through mechanisms of DNA trans-splicing, RNA trans-splicing, or protein splicing via split inteins.5,7 However, dual and triple AAVs typically require higher doses to achieve efficient co-transduction of cells, especially when systemic administration is necessary.10 This makes sense since the likelihood of two or three cargos reaching the same cell should roughly correspond to the proportion of a single cargo reaching the cell squared or cubed respectively.